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16,158 results
  • Vinblastine production by the endophytic fungus Curvularia verruculosa and their in vitro cytotoxicity. [Journal Article]
    Anal Biochem 2019; :113530Parthasarathy R, Shanmuganathan R, Pugazhendhi A
  • The current study was to isolate endophytic fungi producing high yields of indole alkaloids such as vinblastine analogous to their host Cathranthus roseus. Endophytic fungi were isolated from the leaves of C. roseus, identified as Curvularia verruculosa by molecular techniques, the sequence was deposited in NCBI (MK995628). Vinblastine producing endophytic fungus was grown in 1L Vinca medium for …
  • The 3D reconstructed skin micronucleus assay: considerations for optimal protocol design. [Journal Article]
    Mutagenesis 2019Kidd D, Phillips S, … Clements J
  • Implementation of the seventh amendment to the EU Cosmetics Directive has driven much research into suitable in vitro alternative assays to support satisfactory risk assessments. One such assay is the reconstructed skin micronucleus (RSMN) assay. First reported in 2006, further development occurred and a standard protocol was published in 2011. To evaluate and optimise the assay at Covance Labora…
  • Hodgkin lymphoma presenting as alcohol-induced back pain. [Journal Article]
    BMJ Case Rep 2019; 12(11)Ma L, Varma S, Niranjan-Azadi A
  • A 32-year-old Chinese man without significant medical history presented with a 2-month history of worsening lumbosacral back pain radiating to the groin and left lower extremity. He also described a shooting pain in the sciatic nerve distribution that began with and was exacerbated by alcohol consumption, a rare but known symptom of Hodgkin lymphoma (HL). On exam, an anterior chest wall mass was …
  • Two novel nornemoralisin-type diterpenoids from Aphanamixis polystachya (Wall.) R. Parker. [Journal Article]
    Fitoterapia 2019; 140:104431Wu XZ, Fang FH, … Yuan CS
  • Two novel heptanornemoralisin-type diterpenoids nornemoralisins A (1) and B (2), together with two known compounds nemoralisin (3) and nemoralisin A (4), were isolated from the stem bark and leaves of Aphanamixis polystachya (Wall.) R. Parker. Their structures were established through comprehensive analyses of NMR spectroscopic data and high resolution mass spectrometric (HR-ESI-MS) data. The abs…
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