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46,717 results
  • Rhinovirus C15 Induces Airway Hyperresponsiveness Via Calcium Mobilization in Airway Smooth Muscle. [Journal Article]
    Am J Respir Cell Mol Biol 2019Parikh V, Scala J, … Koziol-White CJ
  • Rhinovirus (RV) exposure evokes exacerbations of asthma that markedly impact morbidity and mortality worldwide. The mechanisms by which RV induces airway hyperresponsiveness (AHR) or by which specific RV serotypes differentially evoke AHR remain unknown. We posit that RV infection evokes AHR and inflammatory mediator release, which correlate with levels of RV infection. Further, we posit that RVC…
  • Is Antiretroviral Two-Drug Regimen the New Standard for HIV Treatment in Naive Patients? [Journal Article]
    AIDS Rev 2019; 21(3):143-156Dupont E, Yombi JC
  • The use of a combination antiretroviral therapy (cART) has changed dramatically the prognosis and the life expectancy of people living with HIV. The current treatment guidelines continue the convention of preferred cART based on combining a dual nucleoside reverse-transcriptase inhibitor (NRTI) backbone with a third "anchor" agent, such as a ritonavir (r)- or cobicistat (c)-boosted protease inhib…
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