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(visceromotor viscerimotor)
588 results
  • Peripheral GABA receptors regulate colonic afferent excitability and visceral nociception. [Journal Article]
  • JPJ Physiol 2019; 597(13):3425-3439
  • Loeza-Alcocer E, McPherson TP, Gold MS
  • CONCLUSIONS: While the presence of GABA receptors on primary afferents has been well described, most functional analyses have focused on the regulation of transmitter release from central terminals and/or signalling in the sensory neuron cell body. Evidence that GABA receptors are transported to peripheral terminals and that there are several sources of GABA in the colon raise the possibility that GABA signalling in the periphery may influence colonic afferent excitability. GABAA and GABAB are present and functional in the colon, where exogenous agonists decrease the excitability of colonic afferents and suppress visceral nociception. Endogenous GABA release within the colon is sufficient to establish the resting excitability of colonic afferents as well as the behavioural response to noxious stimulation of the colon, primarily via GABAA receptors. Peripheral GABA receptors may serve as a viable target for the treatment of visceral pain.
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