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14,002 results
  • Continuum Models of Collective Cell Migration. [Journal Article]
    Adv Exp Med Biol 2019; 1146:45-66Banerjee S, Marchetti MC
  • Collective cell migration plays a central role in tissue development, morphogenesis, wound repair and cancer progression. With the growing realization that physical forces mediate cell motility in development and physiology, a key biological question is how cells integrate molecular activities for force generation on multicellular scales. In this review we discuss recent advances in modeling coll…
  • An energy-dissipation-based power-law formulation for estimating hemolysis. [Journal Article]
    Biomech Model Mechanobiol 2019Wu P, Groβ-Hardt S, … Hsu PL
  • Hemolysis is a major concern in blood-circulating devices, which arises due to non-physiological stresses on red blood cells from ambient flow environment or moving mechanical structures. Computational fluid dynamics (CFD) and empirical hemolysis prediction models have been increasingly used for the design and optimization of blood-circulating devices. The commonly used power-law models for hemol…
  • Paper-based passive pumps to generate controllable whole blood flow through microfluidic devices. [Journal Article]
    Lab Chip 2019Sotoudegan MS, Mohd O, … Walker GM
  • Fluid manipulation in microfluidic systems is often controlled by active pumps that are relatively large in size and require external power sources which limit their portability and use in limited-resource settings. In this work, portable, detachable, low-cost, and power-free paper pumps with engineered capillary tubes (referred to as "grooves") that can passively drive viscous fluids based on ca…
  • A thin-film extensional flow model for biofilm expansion by sliding motility. [Journal Article]
    Proc Math Phys Eng Sci 2019; 475(2229):20190175Tam A, Green JEF, … Binder BJ
  • In the presence of glycoproteins, bacterial and yeast biofilms are hypothesized to expand by sliding motility. This involves a sheet of cells spreading as a unit, facilitated by cell proliferation and weak adhesion to the substratum. In this paper, we derive an extensional flow model for biofilm expansion by sliding motility to test this hypothesis. We model the biofilm as a two-phase (living cel…
  • Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection. [Journal Article]
    Nat Microbiol 2019Wheeler KM, Cárcamo-Oyarce G, … Ribbeck K
  • A slimy, hydrated mucus gel lines all wet epithelia in the human body, including the eyes, lungs, and gastrointestinal and urogenital tracts. Mucus forms the first line of defence while housing trillions of microorganisms that constitute the microbiota1. Rarely do these microorganisms cause infections in healthy mucus1, suggesting that mechanisms exist in the mucus layer that regulate virulence. …
  • First-principle description of acoustic radiation of shear flows. [Journal Article]
    Philos Trans A Math Phys Eng Sci 2019; 377(2159):20190077Wu X, Zhang Z
  • As a methodology complementary to acoustic analogy, the asymptotic approach to aeroacoustics seeks to predict aerodynamical noise on the basis of first principles by probing into the physical processes of acoustic radiation. The present paper highlights the principal ideas and recent developments of this approach, which have shed light on some of the fundamental issues in sound generation in shea…
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