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62 results
  • The Phytochemical Composition of Melia volkensii and Its Potential for Insect Pest Management. [Review]
    Plants (Basel). 2020 Jan 22; 9(2)Jaoko V, Nji Tizi Taning C, … Smagghe G
  • Due to potential health and environmental risks of synthetic pesticides, coupled with their non-selectivity and pest resistance, there has been increasing demand for safer and biodegradable alternatives for insect pest management. Botanical pesticides have emerged as a promising alternative due to their non-persistence, high selectivity, and low mammalian toxicity. Six Meliaceae plant species, Az…
  • Neuroplasticity and Repair in Rodent Neurotoxic Models of Spinal Motoneuron Disease. [Review]
    Neural Plast. 2016; 2016:2769735.Gulino R
  • Retrogradely transported toxins are widely used to set up protocols for selective lesioning of the nervous system. These methods could be collectively named "molecular neurosurgery" because they are able to destroy specific types of neurons by using targeted neurotoxins. Lectins such as ricin, volkensin, or modeccin and neuropeptide- or antibody-conjugated saporin represent the most effective tox…
  • Identification of RIP-II toxins by affinity enrichment, enzymatic digestion and LC-MS. [Journal Article]
    Anal Chem. 2015 Jan 20; 87(2):967-74.Fredriksson SÅ, Artursson E, … Åstot C
  • Type 2 ribosome-inactivating protein toxins (RIP-II toxins) were enriched and purified prior to enzymatic digestion and LC-MS analysis. The enrichment of the RIP-II family of plant proteins, such as ricin, abrin, viscumin, and volkensin was based on their affinity for galactosyl moieties. A macroporous chromatographic material was modified with a galactose-terminated substituent and packed into m…
  • Binding and intracellular routing of the plant-toxic lectins, lanceolin and stenodactylin. [Journal Article]
    Biochim Biophys Acta. 2010 Dec; 1800(12):1276-82.Battelli MG, Scicchitano V, … Bolognesi A
  • CONCLUSIONS: The high cytotoxicity of RIPs from the Adenia genus may depend on the following: high affinity binding to the cell and efficient endocytosis, intracellular routing that appears similar to that of other ricin-like toxic RIPs, partial resistance to proteolysis, and, regarding stenodactylin, high accumulation in cell.The data provide a model that could lead to new strategies for anti-cancer therapy and neuroscience studies.
  • Enzymatic activity of toxic and non-toxic type 2 ribosome-inactivating proteins. [Journal Article]
    FEBS Lett. 2004 Apr 09; 563(1-3):219-22.Barbieri L, Ciani M, … Stirpe F
  • Ribosome-inactivating proteins (RIPs) display adenine polynucleotide glycosylase activity on different nucleic acid substrates, which at the ribosomal level is responsible for the arrest of protein synthesis. Some type 2 RIPs, namely ricin and related proteins, are extremely toxic to mammalian cells and animals whilst other type 2 RIPs (non-toxic type 2 RIPs) display three to four logs less toxic…
  • Volkensin from Adenia volkensii Harms (kilyambiti plant), a type 2 ribosome-inactivating protein. [Journal Article]
    Eur J Biochem. 2004 Jan; 271(1):108-17.Chambery A, Di Maro A, … Parente A
  • Volkensin, a type 2 ribosome-inactivating protein from the roots of Adenia volkensii Harms (kilyambiti plant) was characterized both at the protein and nucleotide level by direct amino acid sequencing and cloning of the gene encoding the protein. Gene sequence analysis revealed that volkensin is encoded by a 1569-bp ORF (523 amino acid residues) without introns, with an internal linker sequence o…
  • Glial reaction to volkensin-induced selective degeneration of central neurons. [Journal Article]
    Brain Res Bull. 2001 Mar 01; 54(4):353-61.Cevolani D, Bentivoglio M, Strocchi P
  • Volkensin, a highly toxic protein retrogradely transported through axons, was used to target primary neuronal death in brainstem precerebellar relays after injection in the cerebellar cortex of rats. The reaction of astrocytes and microglia was studied with immunohistochemistry in the inferior olivary and pontine nuclei from 6 h to 14 days. Neurodegenerative features were evident since the first …
  • Neuronal lesioning with axonally transported toxins. [Review]
    J Neurosci Methods. 2000 Nov 15; 103(1):73-82.Wiley RG, Kline IV RH
  • Axonally transported toxins can be used to make selective lesions of the nervous system. Collectively, these techniques are termed 'molecular neurosurgery' because they exploit the surface molecular identity of neurons to selectively destroy specific types of neurons. Suicide transport, is anatomically selective but not type-selective. The most widely used suicide transport agents are the toxic l…
  • Neuronal loss up-regulates clusterin mRNA in living neurons and glial cells in the rat brain. [Journal Article]
    Neuroreport. 1999 Jun 03; 10(8):1789-92.Strocchi P, Rauzi F, Cevolani D
  • The aim of this study was to examine the time course and cellular localization of clusterin mRNA after neurodegeneration. Selective neuronal death was achieved in the rat inferior olivary complex after volkensin injection in the contralateral cerebellar cortex. Quantitative analysis of the in situ hybridization signal demonstrated over-expression of clusterin mRNA in living neurons at 6 days and …
  • Selective loss of cholinergic receptors following unilateral intracortical injection of volkensin. [Journal Article]
    Exp Neurol. 1997 Sep; 147(1):183-91.Chessell IP, Pearson RC, … Francis PT
  • Experimental lesions and quantitative autoradiography were used to investigate the cellular distribution of neurotransmitter receptors in rats. Lesions were produced by intracortical injections of either volkensin or ricin. However, only the former is retrogradely transported and volkensin treatment causes significant loss of contralateral cortical pyramidal neurones. Binding of [3H]pirenzepine (…
  • New approaches to imaging based on effects of neurotoxins. [Review]
    Dement Geriatr Cogn Disord. 1997 Mar-Apr; 8(2):117-22.Francis PT, Chessell IP, Bowen DM
  • Positron and single-photon emission tomography at present visualize only loss of overall brain substance, with a few exceptions. This has improved diagnostic accuracy in the clinic but further improvements could be made. By using toxins, such as volkensin, brain tissues can be produced that are deficient in various subpopulations of cortical pyramidal neurone. Experimental lesions in rats and qua…
  • Reinnervation of rat muscles via volkensin-affected and normal peripheral nerve conduits. [Journal Article]
    Restor Neurol Neurosci. 1997 Jan 01; 11(1):37-45.Nógrádi A, Vrbová G
  • Volkensin is a neurotoxic lectin which, when injected into a peripheral nerve is retrogradely transported to the cell body and causes it to die. Accordingly, volkensin-affected peripheral nerves rapidly degenerate. It is, however, not clear whether axonal growth can take place within these degenerated nerves. In this study the ability of volkensin-treated and untreated degenerated peripheral nerv…
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