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61 results
  • Neuroplasticity and Repair in Rodent Neurotoxic Models of Spinal Motoneuron Disease. [Review]
    Neural Plast 2016; 2016:2769735Gulino R
  • Retrogradely transported toxins are widely used to set up protocols for selective lesioning of the nervous system. These methods could be collectively named "molecular neurosurgery" because they are able to destroy specific types of neurons by using targeted neurotoxins. Lectins such as ricin, volkensin, or modeccin and neuropeptide- or antibody-conjugated saporin represent the most effective tox…
  • Identification of RIP-II toxins by affinity enrichment, enzymatic digestion and LC-MS. [Journal Article]
    Anal Chem 2015; 87(2):967-74Fredriksson SÅ, Artursson E, … Åstot C
  • Type 2 ribosome-inactivating protein toxins (RIP-II toxins) were enriched and purified prior to enzymatic digestion and LC-MS analysis. The enrichment of the RIP-II family of plant proteins, such as ricin, abrin, viscumin, and volkensin was based on their affinity for galactosyl moieties. A macroporous chromatographic material was modified with a galactose-terminated substituent and packed into m…
  • Binding and intracellular routing of the plant-toxic lectins, lanceolin and stenodactylin. [Journal Article]
    Biochim Biophys Acta 2010; 1800(12):1276-82Battelli MG, Scicchitano V, … Bolognesi A
  • CONCLUSIONS: The high cytotoxicity of RIPs from the Adenia genus may depend on the following: high affinity binding to the cell and efficient endocytosis, intracellular routing that appears similar to that of other ricin-like toxic RIPs, partial resistance to proteolysis, and, regarding stenodactylin, high accumulation in cell.The data provide a model that could lead to new strategies for anti-cancer therapy and neuroscience studies.
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