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(wolffian duct)
1,228 results
  • StatPearls: Embryology, Wolffian Ducts [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Yu Megan M University of Virginia Wang Shu-Min SM BOOK
  • The Wolffian ducts (WDs, also known as mesonephric ducts) are paired embryonic structures that serve as progenitors of the male internal genitalia. They develop in the male and female embryos but are only maintained in males by testosterone.[1] The WDs then give rise to the epididymis, vas deferens, and seminal vesicles. Even though the formation of the WDs is dependent on testosterone, the dynam…
  • Genetics of the congenital absence of the vas deferens. [Review]
    Hum Genet. 2020 Feb 05 [Online ahead of print]Bieth E, Hamdi SM, Mieusset R
  • Congenital absence of the vas deferens (CAVD) may have various clinical presentations depending on whether it is bilateral (CBAVD) or unilateral (CUAVD), complete or partial, and associated or not with other abnormalities of the male urogenital tract. CBAVD is usually discovered in adult men either during the systematic assessment of cystic fibrosis or other CFTR-related conditions, or during the…
  • Persistent Mü̈llerian duct syndrome in a beluga whale Delphinapterus leucas. [Journal Article]
    Dis Aquat Organ. 2019 Nov 14; 136(3):273-278.Stimmelmayr R, Ferrer T, Rotstein DS
  • This case study describes a persistent Mü̈llerian duct syndrome (PMDS), a rare form of XY disorder of sex development (DSD), in a mature (>15 yr) beluga whale Delphinapterus leucas. The phenotypically and genetically male beluga whale had both Mü̈llerian (paramesonephric) and Wolffian (mesonephric) duct derivatives. A mild hydrometra was present. Gross and histological analyses indicated the test…
  • A gene regulatory network for Müllerian duct regression. [Review]
    Environ Epigenet. 2019 Jul; 5(3):dvz017.Moses MM, Behringer RR
  • Mammalian embryos initially develop progenitor tissues for both male and female reproductive tract organs, known as the Wolffian ducts and the Müllerian ducts, respectively. Ultimately, each individual develops a single set of male or female reproductive tract organs. Therefore, an essential step for sex differentiation is the regression of one duct and growth and differentiation of the other duc…
  • Transferrin Identification in Sterlet (Acipenser ruthenus) Reproductive System. [Journal Article]
    Animals (Basel). 2019 Sep 30; 9(10)Xin M, Vechtova P, … Sterba J
  • Transferrins are a superfamily of iron-binding proteins and are recognized as multifunctional proteins. In the present study, transcriptomic and proteomic methods were used to identify transferrins in the reproductive organs and sperm of out-of-spawning and spermiating sterlet (Acipenser ruthenus) males. The results showed that seven transferrin transcripts were identified in the transcriptome of…
  • StatPearls: Appendix Testes Torsion [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Pomajzl AJ AJ Creighton University School of Medicine Leslie Stephen W. SW Creighton University Medical Center BOOK
  • Torsion of the testicular appendages is considered to be the most common cause of acute scrotal pain in prepubertal children and may even be the single most prevalent cause of pediatric orchalgia. [1] It should, therefore, be included in the differential for any male presenting with an acute scrotum but especially in the pediatric age group.[1] There are two testicular appendages that can twist a…
  • Female Adnexal Tumor of Probable Wolffian Origin: A Review. [Review]
    Arch Pathol Lab Med. 2020 01; 144(1):24-28.Shalaby A, Shenoy V
  • CONCLUSIONS: FATWO can affect patients from a wide age range and present with a nonspecific clinical presentation. It typically presents as solid tumors with occasional nodular, lobulated, or cystic appearances. FATWO can show a variety of histologic patterns which may result in diagnostic difficulties for pathologists. There is no single specific immunohistochemical stain for FATWO, and the pathogenesis and molecular alterations are not yet well understood. Although it is generally considered a benign entity, recurrent and metastatic cases have been reported. There are no current recommendations regarding the optimal clinical management of FATWO.
  • Deficiency of the transcription factor PLAG1 results in aberrant coiling and morphology of the epididymis. [Journal Article]
    Asian J Androl. 2019 Aug 23 [Online ahead of print]Wong J, Juma AR, … De Groef B
  • Mice deficient in the transcription factor pleomorphic adenoma gene 1 (PLAG1) exhibit reproductive issues that are characterized, in part, by decreased progressive sperm motility in the male. However, the underlying cause of this impairment is unknown. As epididymal transit is critical for sperm maturation and motility, the morphology of the epididymis of Plag1-deficient mice was investigated and…
  • StatPearls: Embryology, Mullerian-inhibiting Factor [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Patel Naiya N FlU/Herbert Wertheim College of Medicine Zafar Gondal Anoosh A Rawal Institute of Health Sciences BOOK
  • Mullerian inhibiting factor (MIF), also called the anti-Mullerian hormone (AMH) plays a significant role in sexual differentiation. It is produced by the Sertoli cells in male fetuses and signals the regression of the Mullerian ducts, fallopian tubes, and uterus. Androgens, which are secreted by Leydig cells, induce differentiation of Wolffian ducts into male internal and external genitalia. 
  • We, the developing rete testis, efferent ducts, and Wolffian duct, all hereby agree that we need to connect. [Review]
    Andrology. 2019 09; 7(5) Mello Santos T, Hinton BT
  • CONCLUSIONS: Fundamental understanding of the morphogenesis of the male reproductive tract is limited, especially the morphogenesis of the rete testis and efferent ducts. Therefore, it is not surprising that we do not understand how each part unites to form a whole. Only one mechanism of joining of one part of the tract to another was identified: the joining of the Wolffian duct to the cloaca via controlled apoptosis.
  • Female Adnexal Tumour of Probable Wolffian Origin (FATWO): Review of the Literature. [Journal Article]
    Geburtshilfe Frauenheilkd. 2019 Mar; 79(3):281-285.Hübner TB, Schwab M, … Herr D
  • FATWO (female adnexal tumour of probable Wolffian origin) denotes a rare tumour of the female adnexa which has been described in nearly 80 cases worldwide and which presumably originates in the remains of the Wolffian ducts. In 10 to 20 percent of patients, a metastasis or recurrence was seen subsequently and for this reason, a malignant potential is attributed to the FATWO. Because of the small …
  • Incidental finding of Zinner syndrome in a Greek military recruit: a case report of a rare clinical entity. [Case Reports]
    Mil Med Res. 2019 02 14; 6(1):4.Symeonidis EN, Gkekas C, … Papathanasiou M
  • CONCLUSIONS: This article aims to present the incidental diagnosis of a rare syndrome in a military setting. Population screening conducted in the armed forces permits the identification of undiagnosed diseases that warrant further investigation. To the best of our knowledge, this was the first report of Zinner syndrome in a military recruit and the second case cited of a Greek patient in the published literature. Regular follow-up is the key to timely intervention in conservatively managed cases.
  • Protocol to Generate Ureteric Bud Structures from Human iPS Cells. [Journal Article]
    Methods Mol Biol. 2019; 1926:117-123.Mae SI, Ryosaka M, Osafune K
  • The generation of ureteric bud (UB), which is the renal progenitor that gives rise to renal collecting ducts and lower urinary tract, from human-induced pluripotent stem cells (hiPSCs) provides a cell source for studying the development of UB and kidney disease. Here we describe a stepwise and efficient two-dimensional differentiation method of hiPSCs into Wolffian duct (WD) cells. We also descri…
  • Tubulocystic anomalies of the mesonephric duct associated with ipsilateral renal dysgenesis. [Journal Article]
    J Pediatr Urol. 2019 Feb; 15(1):46.e1-46.e6.Coleman R, Sanchez O, … Parashar K
  • CONCLUSIONS: When MND tubulocystic structures persist along with renal agenesis or MCDK, most arise from ureteric bud structures in an orthotopic position as a ureterocele with or without a blind-ending ureter-like structure. Less commonly, ureteric bud structures insert ectopically into the urogenital tract, or tubulocystic structures arising from the remainder of the MND occur. Embryogenesis of other urogenital structures may also be abnormal, and conditions such as Zinner syndrome and obstructed hemivagina and ipsilateral renal agenesis syndrome should be considered.Complications are uncommon, and surgical intervention should be limited to symptomatic patients. Remnants of metanephric blastema may involute, but MND remnants persist.
  • Non-obstructive vas deferens and epididymis loss in cystic fibrosis rats. [Journal Article]
    Mech Dev. 2019 02; 155:15-26.Plyler ZE, Birket SE, … Sorscher EJ
  • This study utilizes morphological and mechanistic endpoints to characterize the onset of bilateral atresia of the vas deferens in a recently derived cystic fibrosis (CF) rat model. Embryonic reproductive structures, including Wolffian (mesonephric) duct, Mullerian (paramesonephric) duct, mesonephric tubules, and gonad, were shown to mature normally through late embryogenesis, with involution of t…
  • Pkd2 deletion during embryo development does not alter mesonephric programmed cell senescence. [Journal Article]
    Int J Dev Biol. 2018; 62(9-10):637-640.Da Silva-Álvarez S, Lamas-González O, … Collado M
  • Programmed cell senescence during embryo development is a recently described process that opens a new perspective to understand the senescence response and that adds a new player whose contribution to development needs to be addressed. Identifying developmental syndromes with a root in deregulated programmed cell senescence will undoubtedly reinforce our view of senescence and could provide a new…
  • The development of the cloaca in the human embryo. [Journal Article]
    J Anat. 2018 12; 233(6):724-739.Kruepunga N, Hikspoors JPJM, … Lamers WH
  • Subdivision of cloaca into urogenital and anorectal passages has remained controversial because of disagreements about the identity and role of the septum developing between both passages. This study aimed to clarify the development of the cloaca using a quantitative 3D morphological approach in human embryos of 4-10 post-fertilisation weeks. Embryos were visualised with Amira 3D-reconstruction a…
  • Immunohistochemical expression analysis of the human fetal lower urogenital tract. [Journal Article]
    Differentiation. 2018 Sep - Oct; 103:100-119.Shen J, Isaacson D, … Baskin L
  • We have studied the ontogeny of the developing human male and female urogenital tracts from 9 weeks (indifferent stage) to 16 weeks (advanced sex differentiation) of gestation by immunohistochemistry on mid-sagittal sections. Sixteen human fetal pelvises were serial sectioned in the sagittal plane and stained with antibodies to epithelial, muscle, nerve, proliferation and hormone receptor markers…
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