- Choosing a Career in Heart Failure. [Journal Article]
- CHCirc Heart Fail 2019; 12(7):e006139
- A Qualitative Study Exploring the Determinants, Coping, and Effects of Stress in United Kingdom Trainee Doctors. [Journal Article]
- APAcad Psychiatry 2019 Jul 09
- CONCLUSIONS: A range of determinants contributes to stress in trainee doctors and they utilize a range of mechanisms to cope. Stress in their working lives can also affect their wellbeing and careers. These findings could be used to improve the understanding of stress in trainee doctors and assist in the development of supportive interventions.
- Migration intentions among physicians working in Polish hospitals - Insights from survey research. [Journal Article]
- HPHealth Policy 2019 Jun 26
- CONCLUSIONS: Special attention should be paid to improving working conditions, including salary, but also reducing bureaucracy, improvement of work-climate and training opportunities.
- Female oncologists in the Middle East and North Africa: progress towards gender equality. [Journal Article]
- EOESMO Open 2019; 4(3):e000487
- CONCLUSIONS: In what is considered a male dominant environment, gender equality according to female oncologists working in the Middle East, is very comparable to the world data provided. Several strategies have been identified to continue progress in this domain with the aim to improve academic leadership opportunities and work-life balance for all.
- Exploring Women's Multi-Level Career Prospects in Pakistan: Barriers, Interventions, and Outcomes. [Journal Article]
- FPFront Psychol 2019; 10:1376
- Utilizing the relational framework of diversity management and social role theory, this exploratory study illuminates the career prospects of women working in the patriarchal society of Pakistan. Wit…
Utilizing the relational framework of diversity management and social role theory, this exploratory study illuminates the career prospects of women working in the patriarchal society of Pakistan. With the help of Nvivo 12 Plus, themes were generated based on 27 in depth, semi-structured interviews. The findings showed an interrelated web of factors interacting at three levels; macro, meso, and micro; that were explained on the premises of the social role theory. Major impediments to women's career progress were religious interpretations, socio-cultural factors and Sifarish (i.e., favoritism/nepotism) at the macro-level. At the meso-level, the barriers involved segregation, discrimination, harassment, and lack of work-family balance initiatives at the workplace. The micro-level obstacles involved personal values and needs, queen bee syndrome and a lack of awareness. The experiences of Pakistani women varied based on socio-economic status, marriage, religion and various aspects of individual identity, that intersected with gender and accordingly affected their career outcomes either positively or negatively. Therefore, the study also contributes to the emergent area of intersectional studies which posits that individuals experience various facets of identity concurrently and that these factors do not operate separately but are interrelated and interact. Moreover, the study also highlights the interventions for creating gender parity like clarification of Islamic guidelines, strict accountability of workplace policies, and the provision of work-family balance support. The outcomes highlighted by the respondents included happiness, confidence, agency, and improved quality of life. The paper concludes with implications for theory and practice, limitations, and future research avenues.
- [Thyroid hormones regulate neural stem cell fate]. [Journal Article]
- BABiol Aujourdhui 2019; 213(1-2):7-16
- Thyroid hormones (THs) are vital for vertebrate brain function throughout life, from early development to ageing. Epidemiological studies show an adequate supply of maternal TH during pregnancy to be…
Thyroid hormones (THs) are vital for vertebrate brain function throughout life, from early development to ageing. Epidemiological studies show an adequate supply of maternal TH during pregnancy to be necessary for normal brain development, and this from the first trimester of onwards. Maternal TH deficiency irreversibly affects fetal brain development, increasing the risk of offspring cognitive disorders and IQ loss. Mammalian and non-mammalian (zebrafish, xenopus, chicken) models are useful to dissect TH-dependent cellular and molecular mechanisms governing embryonic and fetal brain development: a complex process including cell proliferation, survival, determination, migration, differentiation and maturation of neural stem cells (NSCs). Notably, rodent models have strongly contributed to understand the key neurogenic roles of TH still at work in adult life. Neurogenesis continues in two main areas, the sub-ventricular zone lining the lateral ventricles (essential for olfaction) and the sub-granular zone in the dentate gyrus of the hippocampus (involved in memory, learning and mood control). In both niches, THs tightly regulate the balance between neurogenesis and oligodendrogenesis under physiological and pathological contexts. Understanding how THs modulate NSCs determination toward a neuronal or a glial fate throughout life is a crucial question in neural stem cell biology. Providing answers to this question can offer therapeutic strategies for brain repair, notably in neurodegenerative diseases, demyelinating diseases or stroke where new neurons and/or oligodendrocytes are required. The review focuses on TH regulation of NSC fate in mammals and humans both during development and in the adult.
- Role Modeling for Female Surgeons in Japan. [Journal Article]
- TJTohoku J Exp Med 2019; 248(3):151-158
- Japan is still a patriarchal society. There is an increasing number of female doctors who wish to follow a career path in surgery. This new generation of female surgeons need support not only in thei…
Japan is still a patriarchal society. There is an increasing number of female doctors who wish to follow a career path in surgery. This new generation of female surgeons need support not only in their career but also in work-life balance, especially after they have a family. We founded the Japan Association of Women Surgeons (JAWS) with the aims to advance females in surgery by providing networking and to develop leadership, mentorship, education, expertise and advocacy. This article describes our philosophy and activities, and our concept of role modeling. To find a single perfect role model is impossible in Japan, because lifestyle and family situations are quite different among individuals. Many young doctors in Japan find difficulties in identifying role models appropriate to their own situations. Our concept of remote role modeling is to identify multiple outstanding persons with excellent roles that one wishes to emulate; classify them by field of work, lifestyle, family situations, and others; then select the parts that one needs and assemble them to customize one's own ideal role model. This type of role modeling is probably the most practical approach. While modern technology is good for communication, meeting role models in person at meetings and social occasions is important in building an ideal role model.
- Trends in Surgeon Wellness (Take a Sad Song and Make It Better): A Comparison of Surgical Residents, Fellows, and Attendings. [Journal Article]
- ASAm Surg 2019 Jun 01; 85(6):579-586
- We aim to investigate the prevalence of posttraumatic stress disorder (PTSD), physician burnout (PBO), and work-life balance (WLB) among surgical residents, fellows, and attendings to illustrate the …
We aim to investigate the prevalence of posttraumatic stress disorder (PTSD), physician burnout (PBO), and work-life balance (WLB) among surgical residents, fellows, and attendings to illustrate the trends in surgeon wellness. A cross-sectional national survey of surgical residents, fellows, and attendings was conducted screening for PTSD, PBO, and WLB. The prevalence of screening positive for PTSD was more than two times that of the general population at all levels of experience, and more than half have an unhealthy WLB. The prevalence of PTSD, PBO, and unhealthy WLB declined with increasing level of experience (P < 0.001). One deviation in this trend was a lower prevalence of PBO among surgical fellows compared with residents and attendings (P < 0.001). Surgeon wellness improved with increasing level of experience. The incorporation of wellness programs into surgical residencies is essential to the professional development of young surgeons to cultivate healthy lasting habits for a well-balanced career and life.
- Perceived occupational balance in people with stroke. [Journal Article]
- DRDisabil Rehabil 2019 Jul 02; :1-6
- CONCLUSIONS: These results demonstrate the importance of considering occupational balance in the rehabilitation of persons with stroke to support their engagement in a variety of meaningful activities that contribute to health. IMPLICATIONS FOR REHABILITATION Rehabilitation need to support persons with stroke to monitor their entire patterns of activities and perceived balance to support wider engagement in meaningful activities and promote health. Balance between all kinds of activities in daily life besides work, needs to be considered in the later phase of rehabilitation in persons with stroke. A majority of the participants with stroke in this study disagreed that they had a satisfying level of occupational balance. Perceived balance between all activities in daily life can together with performance of activities add to the understanding of consequences after stroke.
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- Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1. [Journal Article]
- CCancers (Basel) 2019 Jun 28; 11(7)
- Clinical use of the anti-cancer drug doxorubicin (DOX) is largely limited due to its severe cardiotoxicity. Dysregulation of autophagy is implicated in DOX-induced cardiotoxicity (DIC). Prior studies…
Clinical use of the anti-cancer drug doxorubicin (DOX) is largely limited due to its severe cardiotoxicity. Dysregulation of autophagy is implicated in DOX-induced cardiotoxicity (DIC). Prior studies have indicated that Beclin1 and lysosomal-associated membrane proteins-1 (LAMP1) are critical mediators of autophagy. In this work, by assessing autophagic flux in a DOX-stimulated H9C2 model, we observed autolysosome accumulation caused by interruption of autolysosome degradation. Tanshinone IIA (TSA) is a well-known small molecule that exerts impressive cardioprotective effects on heart failure. Here, we investigated the regulation of TSA in DOX-treated zebrafish, mice, and H9C2 models. Results demonstrated that TSA remarkably improved heart function and reversed pathological changes in vivo, while TSA restored autophagic flux by promoting autolysosome degradation and autophagosome formation. Further experiments demonstrated that these effects were mediated through upregulation of Beclin1 and LAMP1. The mTOR agonist MHY1485 was shown to abrogate the effect of TSA via the UNC-51-like kinase 1 (ULK1)-Beclin1/TFEB-LAMP1 signaling pathway in vitro, demonstrating that TSA protects against DIC by promoting autophagy via the Beclin1/LAMP1 signaling pathway. We further employed a U87 model to assess whether TSA would compromise the antitumor activity of DOX. Intriguingly, the co-treatment of TSA was able to synergistically inhibit proliferative activity. Collectively, in this study we uncover the novel insight that TSA is able to reduce the cardiotoxicity of DOX without compromising antitumor activity.