- Association between objective sleep duration and bone mineral density in older postmenopausal women from the Study of Osteoporotic Fractures (SOF). [Journal Article]
- OIOsteoporos Int 2019 May 28
- CONCLUSIONS: Nocturnal sleep duration, whether assessed objectively (actigraphy) or subjectively (questionnaire), was not independently associated with BMD in older postmenopausal women.
- Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study. [Journal Article]
- JCJ Cosmet Dermatol 2019 May 28
- CONCLUSIONS: The composition of the microneedle patches works in a multi-targeted manner and all ingredients might possibly be acted synergistically for the improvement of skin structure, function, and appearance. The study has demonstrated the overall usefulness of the HA-MNs with careful formulation for skin care applications.
- A tool for empirical equipoise assessment in multigroup comparative effectiveness research. [Journal Article]
- PDPharmacoepidemiol Drug Saf 2019 May 27
- CONCLUSIONS: Our proposed tool may be useful in guiding cohort identification in multigroup observational studies, particularly with similar effects of unmeasured and measured covariates on treatment and outcome.
- Anti-Photoaging Effects of Four Insect Extracts by Downregulating Matrix Metalloproteinase Expression via Mitogen-Activated Protein Kinase-Dependent Signaling. [Journal Article]
- NNutrients 2019 May 23; 11(5)
- Insects are some of the most diverse organisms on the planet, and have potential value as food or medicine. Here, we investigated the photoprotective properties of insect extracts using hairless mice…
Insects are some of the most diverse organisms on the planet, and have potential value as food or medicine. Here, we investigated the photoprotective properties of insect extracts using hairless mice. The alleviating wrinkle formation effects of insect extracts were evaluated by histological skin analysis to determine epidermal thickness and identify collagen fiber damage. Moreover, we investigated the ability of the insect extracts to alleviate UVB-induced changes to matrix metalloproteinases (MMPs), oxidative damage, the mitogen-activated protein kinases (MAPKs) signaling pathway, and the expression of pro-inflammatory cytokines. Insect extracts reduced UVB-induced skin winkles, epidermal thickening, and collagen breakdown, and alleviated the epidermal barrier dysfunction induced by UVB, including the increased loss of transepidermal water. Moreover, the expression of skin hydration-related markers such as hyaluronic acid, transforming growth factor-beta (TGF-β), and procollagen was upregulated in the group treated with insect extracts compared to the vehicle-treated group after ultraviolet B (UVB) exposure. UVB irradiation also upregulated the expression of MMPs, the phosphorylation of MAPKs, and pro-inflammatory cytokines, which were all attenuated by the oral administration of insect extracts. These results indicate the photoaging protection effect of insect extracts and the underlying mechanism, demonstrating the potential for clinical development.
- Skin characterization and immediate effects of different dermocosmetic treatments in French and Brazilian skin. [Journal Article]
- JCJ Cosmet Dermatol 2019 May 24
- CONCLUSIONS: Despite the differences found in French and Brazilian skin, the proposed dermocosmetic treatments showed effective in both populations.
- Magnetic nitrogen-doped reduced graphene oxide as a novel magnetic solid-phase extraction adsorbent for the separation of bisphenol endocrine disruptors in carbonated beverages. [Journal Article]
- TTalanta 2019 Aug 15; 201:194-203
- A novel magnetic nitrogen-doped reduced graphene oxide (Fe3O4@N-RGO) had been fabricated for the first time on the basis of a simple solvothermal method and then was successfully applied to extract f…
A novel magnetic nitrogen-doped reduced graphene oxide (Fe3O4@N-RGO) had been fabricated for the first time on the basis of a simple solvothermal method and then was successfully applied to extract four bisphenol endocrine disruptors (bisphenol A, bisphenol B, bisphenol F and bisphenol AP) in carbonated beverages coupled with high performance liquid chromatography (HPLC). The as-prepared Fe3O4@N-RGO was characterized by transmission electron microscopy (TEM), Brunner-Emmet-Teller (BET), X-ray diffraction (XRD), X-ray photoelectron spectrometer (XPS) and vibrating sample magnetometer (VSM). The introduction of nitrogen atoms not only made the wrinkle level of N-RGO increased, but also retarded the irreversible aggregation of graphene sheets. Compared with Fe3O4@RGO, Fe3O4@N-RGO owned larger specific surface area and more adsorption sites. Hence, Fe3O4@N-RGO showed excellent extraction efficiency toward bisphenol endocrine disruptors. The analytical parameters influencing the extraction efficiency were optimized in detail. Under the optimal conditions, a satisfactory performance was obtained. The calibration lines were linear over the concentration in the range of 0.4-1000 μg L-1 with determination coefficients (r2) between 0.9976 and 0.9996. The limits of detection (LOD) ranged from 0.1 μg L-1 to 0.2 μg L-1. The recoveries varied from 86.52% to 101.47% with relative standard deviations (RSDs) less than 8.59%. Overall, the proposed method was an efﬁcient pretreatment and enrichment procedure and could be successfully applied for selective extraction and determination of bisphenol endocrine disruptors in complex matrices.
- Functional Fragments of AIMP1-Derived Peptide (AdP) and Optimized Hydrosol for Their Topical Deposition by Box-Behnken Design. [Journal Article]
- MMolecules 2019 May 22; 24(10)
- Aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1)-derived peptide (AdP) has been developed as a cosmeceutical ingredient for skin anti-aging given its fibroblast-activat…
Aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1)-derived peptide (AdP) has been developed as a cosmeceutical ingredient for skin anti-aging given its fibroblast-activating (FA) and melanocyte-inhibiting (MI) functions. However, a suitable strategy for the topical delivery of AdP was required due to its low-permeable properties. In this study, FA and MI domains of AdP (FA-AdP and MI-AdP, respectively) were determined by functional domain mapping, where the activities of several fragments of AdP on fibroblast and melanocyte were tested, and a hydrosol-based topical delivery system for these AdP fragments was prepared. The excipient composition of the hydrosol was optimized to maximize the viscosity and drying rate by using Box-Behnken design. The artificial skin deposition of FA-AdP-loaded hydrosol was evaluated using Keshary-Chien diffusion cells equipped with Strat-M membrane (STM). The quantification of the fluorescent dye-tagged FA-AdP in STM was carried out by near-infrared fluorescence imaging. The optimized hydrosol showed 127-fold higher peptide deposition in STM than free FA-AdP (p < 0.05). This work suggests that FA- and MI-AdP are active-domains for anti-wrinkle and whitening activities, respectively, and the hydrosol could be used as a promising cosmetic formulation for the delivery of AdPs to the skin.
- In search of a universal and objective method to assess facial aging: The new face objective photo-numerical assessment scale. [Journal Article]
- JCJ Craniomaxillofac Surg 2019 Mar 16
- Most patients who undergo cosmetic rejuvenation treatment hope to appear younger and healthier. Although a number of scales have been put forward to assess facial aging, to date none has focused on p…
Most patients who undergo cosmetic rejuvenation treatment hope to appear younger and healthier. Although a number of scales have been put forward to assess facial aging, to date none has focused on predicting patients' age. The purpose of our study was to validate a more complete version of the face - Objective assessment scale previously developed by the authors. Since patients with a photo-damaged skin can look older than others we created a new sub-scale: the facial photo-aging scale, in order to provide a more comprehensive method for the overall assessment of facial aging. The Rasch model was used as part of the validation process. We assigned a score to each patient based on the scales we have developed. The correlation between a patient's actual age and the obtained scores was analyzed; we also analyzed the inter-rater reliability and test-retest reliability. All the scales exceeded criteria for acceptability, reliability and validity. The facial aging scale we have developed may prove to be a valuable tool to assess patients before and after facial rejuvenation treatment or surgery, as well as for clinical research in the field of facial skin regeneration.
- Dermocosmetic emulgels for anti-aging effects: Evidence from chromatographic and non-invasive biophysical techniques. [Journal Article]
- PJPak J Pharm Sci 2019; 32(2 (Supplementary)):845-852
- Persimmon Fruits (Diospyros kaki L.f, Ebenaceae) and its active principles have long been used in traditional medicines for various cosmetics and skin conditions, however clinical efficacy on various…
Persimmon Fruits (Diospyros kaki L.f, Ebenaceae) and its active principles have long been used in traditional medicines for various cosmetics and skin conditions, however clinical efficacy on various facial skin parameters like roughness, scaliness, hydration, elasticity and wrinkles have not yet been reported. Current study was aimed to analyse polyphenolic constituents of Diospyros kaki fruit extract (DKFE) and to clinically evaluate dermocosmetic emulgels loaded with bioactive phytoconstituents from persimmon fruits, using non-invasive in-vivo evaluation techniques. HPLC analysis established the presence of quercetin, gallic acid, chlorogenic acid, ferulic acid, p-coumeric acid, catechin and cinnamic acid. Results revealed that test formulation produced significant and control showed insignificant (p>0.05) effects on moisture contents and elasticity. Surface evaluation of living skin (SELS) index values were reduced significantly (p<0.05) for the emulgels loaded with DKFE, represented by reduction in skin wrinkles (-12.40%), roughness (-11.76%) and scaliness (-18.59%). Conclusively, a safe and compatible dermocosmetic emulgel formulation loaded with antioxidant enriched DKFE, revealed promising anti-aging attributes that may be due to presence of vital polyphenolic constituents as presented by HPLC analysis.
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- The effects of aging on hydromorphone-induced thermal antinociception in healthy female cats. [Journal Article]
- PRPain Rep 2019 Mar-Apr; 4(2):e722
- CONCLUSIONS: Pediatric cats may require more frequent dosing of hydromorphone than adults.