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1,117 results
  • Dose and formulation of azithromycin in mass drug administration studies: a systematic review protocol. [Systematic Review]
    BMJ Paediatr Open 2019; 3(1):e000462Yue Y, Xiong T, … Mu D
  • Azithromycin has been given for tropical infectious diseases such as trachoma and yaws by mass drug administration (MDA). As well as controlling the infectious disease in question, MDA may have a beneficial effect in reducing mortality in young children. However, the dose, formulation, frequency and duration of azithromycin used in certain infectious diseases may vary in different studies, and th…
  • Identification of positively selected genes in human pathogenic treponemes: Syphilis-, yaws-, and bejel-causing strains differ in sets of genes showing adaptive evolution. [Journal Article]
    PLoS Negl Trop Dis 2019; 13(6):e0007463Maděránková D, Mikalová L, … Šmajs D
  • CONCLUSIONS: The syphilis-, yaws-, and bejel-causing strains differed relative to sets of positively selected genes. Most of the positively selected chromosomal loci were identified among the TPA treponemes. The local accumulation of genetic variability suggests that the diversification of TPA strains took place predominantly in a limited number of genomic regions compared to the more dispersed genetic diversity differentiating TPE and TEN strains. The identification of positively selected sites in tpr genes and genes encoding outer membrane proteins suggests their role during infection of human and animal hosts. The driving force for adaptive evolution at these loci thus appears to be the host immune response as supported by observed reactivity of syphilitic sera with some peptides derived from protein sequences showing adaptive evolution.
  • Neglected tropical diseases: elimination and eradication. [Journal Article]
    Clin Med (Lond) 2019; 19(2):157-160Bodimeade C, Marks M, Mabey D
  • The term neglected tropical diseases (NTDs) describes a disparate group of diseases which affect populations living in poverty and are important causes of morbidity and mortality worldwide. Global programmes for the control of NTDs benefit large-scale donations made by pharmaceutical companies. A number of NTDs have internationally agreed targets for their control, elimination and eradication. Er…
  • Epidemiological situation of yaws in the Americas: A systematic review in the context of a regional elimination goal. [Journal Article]
    PLoS Negl Trop Dis 2019; 13(2):e0007125Zoni AC, Saboyá-Díaz MI, … Blaya-Novakova V
  • CONCLUSIONS: The lack of recent yaws publications may reflect, in the best-case scenario, the interruption of yaws transmission. It should be possible to reach the eradication goal in the region of the Americas, but it is necessary to collect more information. We suggest updating the epidemiological status of yaws, especially in two countries that need to assess ongoing transmission. Twenty-four countries need to demonstrate the interruption of transmission and declare its status of yaws endemicity, and sixteen countries should declare if they are yaws-free. It is necessary to formally verify the achievement of this goal in Ecuador.
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