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556 results
  • Asthma pharmacotherapy: an update on leukotriene treatments. [Journal Article]
    Expert Rev Respir Med 2019; :1-10Trinh HKT, Lee SH, … Park HS
  • Introduction: Asthma is a chronic inflammatory disease of the airways with a large heterogeneity of clinical phenotypes. There has been increasing interest regarding the role of cysteinyl leukotriene (LT) and leukotriene receptor antagonists (LTRA) in asthma treatment. Areas covered: This review summarized the data (published in PubMed during 1984-2019) regarding LTRA treatment in asthma and LTs-…
  • Novel zafirlukast derivatives exhibit selective antibacterial activity against Porphyromonas gingivalis. [Journal Article]
    Medchemcomm 2019; 10(6):926-933Thamban Chandrika N, Fosso MY, … Garneau-Tsodikova S
  • Periodontal disease is an oral chronic immune-inflammatory disease highly prevalent worldwide that is initiated by specific oral bacterial species leading to local and systemic effects. The development of new preventive/therapeutic strategies to specifically target oral periodontopathogens without perturbing oral microbiome species normally colonizing the oral cavity is needed. The fast and affor…
  • Virtual screening of novel compounds as potential ER-alpha inhibitors. [Journal Article]
    Bioinformation 2019; 15(5):321-332TilakVijay J, Vivek Babu K, Uma A
  • Majority of breast cancers diagnosed today are estrogen receptor (ER)-positive, however, progesterone receptor-positive (PR-positive) is also responsible for breast cancer. Tumors that are ER/PR-positive are much more likely to respond to hormone therapy than tumors that are ER/PR-negative. Nearly 105 ERa inhibitors from literature when docked resulted in 31 compounds (pyrazolo[1,5-a]pyrimidine a…
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