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33,847 results
  • Orbital apex syndrome secondary to herpes zoster ophthalmicus. [Journal Article]
    Arch Soc Esp Oftalmol. 2020 Jul 08 [Online ahead of print]Ruiz-Arranz C, Reche-Sainz JA, … Ferro-Osuna M
  • Herpes zoster ophthalmicus usually presents with ocular manifestations, but neurological complications are much more infrequent. An 84-year-old woman with herpes zoster of the left first trigeminal branch developed herpetic keratouveitis in her left eye despite treatment with oral valaciclovir. Seven days later, a progressive and total left ophthalmoplegia appeared, requiring hospital admission a…
  • The Dual PDZ Domain from Postsynaptic Density Protein 95 Forms a Scaffold with Peptide Ligand. [Journal Article]
    Biophys J. 2020 Jun 26 [Online ahead of print]Rodzli NA, Lockhart-Cairns MP, … Prince SM
  • PSD-95 is a member of the membrane-associated guanylate kinase class of proteins that forms scaffolding interactions with partner proteins, including ion and receptor channels. PSD-95 is directly implicated in modulating the electrical responses of excitable cells. The first two PSD-95/disks large/zona occludens (PDZ) domains of PSD-95 have been shown to be the key component in the formation of c…
  • Unusual Case of Granuloma Annulare Associated with Diabetes Mellitus. [Journal Article]
    Acta Dermatovenerol Croat. 2020 Jul; 28(1):45-46.Patrun S, Ljubojević Hadžavdić S
  • Dear Editor, Granuloma annulare (GA) is an asymptomatic, chronic, and relatively common granulomatous skin condition which presents with annular papules usually slowly progressing into plaques on the extremities and the trunk. It usually presents with non-scaly, erythematous, annular plaques on the distal extremity (1,2). The pathogenesis of GA is still unknown, although a variety of possible fac…
  • The neuroanatomy and neurochemistry of sleep-wake control. [Journal Article]
    Curr Opin Physiol. 2020 Jun; 15:143-151.Gompf HS, Anaclet C
  • Sleep-wake control is dependent upon multiple brain areas widely distributed throughout the neural axis. Historically, the monoaminergic and cholinergic neurons of the ascending arousal system were the first to be discovered, and it was only relatively recently that GABAergic and glutamatergic wake- and sleep-promoting populations have been identified. Contemporary advances in molecular-genetic t…
  • The FLUXNET2015 dataset and the ONEFlux processing pipeline for eddy covariance data. [Journal Article]
    Sci Data. 2020 Jul 09; 7(1):225.Pastorello G, Trotta C, … Papale D
  • The FLUXNET2015 dataset provides ecosystem-scale data on CO2, water, and energy exchange between the biosphere and the atmosphere, and other meteorological and biological measurements, from 212 sites around the globe (over 1500 site-years, up to and including year 2014). These sites, independently managed and operated, voluntarily contributed their data to create global datasets. Data were qualit…
  • Species richness both impedes and promotes alien plant invasions in the Brazilian Cerrado. [Journal Article]
    Sci Rep. 2020 Jul 09; 10(1):11365.Lannes LS, Karrer S, … Olde Venterink H
  • Worldwide, alien plant invasions have been intensively studied in the past decades, but mechanisms controlling the invasibility of native communities are not fully understood yet. The stochastic niche hypothesis predicts that species-rich plant communities are less prone to alien plant invasions than species-poor communities, which is supported by some but not all field studies, with some very sp…
  • Ophthalmic Shingles with Simultaneous Acute Retinal Necrosis in the Opposite Eye. [Journal Article]
    Ocul Immunol Inflamm. 2020 Jul 09 [Online ahead of print]Battista M, Marchese A, … Miserocchi E
  • CONCLUSIONS: Herpes Zoster Ophtalmicus (HZO) represents the 10-20% of Herpes Zoster (HZ) cases and ARN is a rare but sight-threatening complication due to the viral widespread along the retina. By definition, the reactivation of Varicella Zoster virus (VZV) has a unilateral clinical expression, due to the centrifugal neural pathway followed by the virus from the neural ganglia, and HZO, as well, results located on the same side of the skin affection. The case presented contradicted this postulate.prompt diagnosis, through fundus examination and FA, and proper antiviral therapy were the mainstays to counteract the posterior uveitis. Nowadays, vaccination is a safe weapon to efficaciously reduce the ZVZ incidence among general population.
  • Efficacy and safety of peficitinib in rheumatoid arthritis. [Journal Article]
    Mod Rheumatol. 2020 Jul 09 [Online ahead of print]Kaneko Y
  • Peficitinib is a Janus kinase (JAK) inhibitor, newly developed and approved in Japan. In contrast to other JAK inhibitors, it is a unique pan-JAK inhibitor, demonstrating inhibition of all JAKs. In patients with rheumatoid arthritis with an inadequate response to previous disease-modifying anti-rheumatic drugs, the efficacy of peficitinib (100 mg and 150 mg) has been confirmed with a comparison t…
  • Intracranial calcifications in childhood: Part 2. [Journal Article]
    Pediatr Radiol. 2020 Jul 08 [Online ahead of print]Gonçalves FG, Caschera L, … Vossough A
  • This article is the second of a two-part series on intracranial calcification in childhood. In Part 1, the authors discussed the main differences between physiological and pathological intracranial calcification. They also outlined histological intracranial calcification characteristics and how these can be detected across different neuroimaging modalities. Part 1 emphasized the importance of age…
  • Population pharmacokinetics of isoniazid and dose recommendations in Mexican patients with tuberculosis. [Journal Article]
    Int J Clin Pharm. 2020 Jul 07 [Online ahead of print]Huerta-García AP, Medellín-Garibay SE, … Milán-Segovia RDC
  • Background The standardized doses of isoniazid in therapy against tuberculosis are determined based on total body weight, without considering genetic polymorphisms of the metabolic enzyme N-acetyltransferase-2 that contribute to the wide pharmacokinetic variability of isoniazid. Objective The aim of this work was to build a population pharmacokinetic model of isoniazid in Mexican patients with tu…
  • A case of Disseminated Herpes Zoster in a patient with Multiple Sclerosis on Glatiramer acetate. [Case Reports]
    IDCases. 2020; 21:e00873.Halasan C, Isache C, Sands M
  • We present a case of Disseminated Herpes Zoster in a 73 year old man who had been taking Glatiramer acetate for 8 years as treatment for Multiple Sclerosis. He presented to the emergency room with complaints of a painful skin lesions on his buttocks and was found to have a generalized papulo-pustular rash. He was treated with IV Acyclovir and concurrent Piperacillin-Tazobactam plus Vancomycin for…
  • Strategies to Improve Vaccination among At-Risk Adults and the Elderly in Italy. [Journal Article]
    Vaccines (Basel). 2020 Jul 04; 8(3)Calabrò GE, Tognetto A, … de Waure C
  • The World Health Organization (WHO), the United States (US) Centers for Disease Control and Prevention (CDC), the European Center for Disease Control (ECDC), and the immunization guidelines of many countries issue vaccination recommendations for adults and the elderly. However, the uptake of vaccination in these groups is generally low due to several reasons. The present study aimed to identify s…
  • Pregabalin-associated stuttering and frequent blepharospasm: case report and review. [Journal Article]
    Daru. 2020 Jul 06 [Online ahead of print]Ge L, Li A, … Li W
  • Herpes zoster is an acute, painful, herpes skin disease caused by varicella-zoster virus, which may cause viral meningitis. Pregabalin has been shown to be efficacious in the treatment of pain in patients with herpes zoster. However, it has the side effects of neurotoxicity. We describe a 68-year-old female patient with herpes zoster, and she was treated with pregabalin. The patient presented wit…
  • A conceptual value-based incentivization model of adult immunization for community pharmacists. [Journal Article]
    J Am Pharm Assoc (2003). 2020 Jul 03 [Online ahead of print]Berenbrok LA, Renner HM, … Coley KC
  • CONCLUSIONS: A conceptual value-based payment model to incentivize pharmacists for increased delivery of adult vaccinations at community pharmacies was designed and agreed on by experts representing a regional supermarket pharmacy, a self-insured employer, a managed care organization, and an academic institution. Consensus was achieved by aligning the interests of both payers and pharmacies. The final model included 3 tiers of bundled incentives to reward percent increases in adult vaccination from historical baselines. This model may be used as an example for community pharmacies and health care payers to design future value-based immunization programs.
  • Regulatory Effect of Lactobacillus brevis Bmb6 on Gut Barrier Functions in Experimental Colitis. [Journal Article]
    Foods. 2020 Jul 02; 9(7)Shin MY, Yong CC, Oh S
  • The integrity of gut barrier functions is closely associated with the pathogenesis of colitis. It is speculated that Lactobacillus brevis Bmb6 alleviates colitis by improving the tight junction (TJ) of the inflamed intestinal epithelial layer. In the present study, the regulatory effects of L. brevis Bmb6 on the TJ barrier to ameliorate colitis-symptoms were investigated. Preliminary screening sh…
  • Safety of Tofacitinib in a Real-World Cohort of Patients With Ulcerative Colitis. [Journal Article]
    Clin Gastroenterol Hepatol. 2020 Jul 03 [Online ahead of print]Deepak P, Alayo QA, … Yarur A
  • CONCLUSIONS: Real-world safety signals for tofacitinib are similar to those for clinical trials, with AEs reported from almost 16% of patients. HZ infection and VTE occurred in patients receiving 10 mg tofacitinib twice per day. These results support dose de-escalation after induction therapy, to reduce the risk of AEs.
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