Abstract
Common variable immunodeficiency disorder (CVID) is diverse, both in its clinical presentation and in the types of deficiency. It is a primary humoral immunodeficiency disorder characterized by reduced serum levels of immunoglobulin G (IgG) and immunoglobulin A (IgA) or immunoglobulin M (IgM), recurrent sinopulmonary infections, autoimmune disorders, granulomatous diseases, enhanced risk of malignancy, and impaired antibody response despite the adequate number of B cells.[1][2] It is the most frequent symptomatic primary immunodeficiency disorder worldwide.[2][3] Rather than a disease, it is a collection of hypogammaglobulinemia syndromes resulting from various genetic defects (almost all of them are specific molecular defects with as yet an unknown cause),[1] named “variable” because of its heterogeneous clinical manifestations.[4]
TY - CHAP
T1 - Common Variable Immunodeficiency
BT - StatPearls
A1 - Pescador Ruschel,Marco A.,
AU - Vaqar,Sarosh,
Y1 - 2021/01//
PY - 2019/11/21/pubmed
PY - 2019/11/21/medline
PY - 2019/11/21/entrez
N2 - Common variable immunodeficiency disorder (CVID) is diverse, both in its clinical presentation and in the types of deficiency. It is a primary humoral immunodeficiency disorder characterized by reduced serum levels of immunoglobulin G (IgG) and immunoglobulin A (IgA) or immunoglobulin M (IgM), recurrent sinopulmonary infections, autoimmune disorders, granulomatous diseases, enhanced risk of malignancy, and impaired antibody response despite the adequate number of B cells.[1][2] It is the most frequent symptomatic primary immunodeficiency disorder worldwide.[2][3] Rather than a disease, it is a collection of hypogammaglobulinemia syndromes resulting from various genetic defects (almost all of them are specific molecular defects with as yet an unknown cause),[1] named “variable” because of its heterogeneous clinical manifestations.[4]
PB - StatPearls Publishing
CY - Treasure Island (FL)
UR - https://www.unboundmedicine.com/prime/citation/31747194/StatPearls:_Common_Variable_Immunodeficiency
L2 - https://www.ncbi.nlm.nih.gov/books/NBK549787
DB - PRIME
DP - Unbound Medicine
ER -
