Delgocitinib is a pan-Janus kinase (JAK) inhibitor that targets all four JAK isoforms. Delgocitinib 20 mg/g cream (Anzupgo[®] 20 mg/g), a non-steroidal therapy, is the first topical treatment indicated in the EU for moderate to severe chronic hand eczema (CHE) in adults for whom topical corticosteroids are inadequate or inappropriate. In two 16-week, double-blind, vehicle-controlled, multinational phase III trials, twice-daily delgocitinib 20 mg/g cream improved the signs and symptoms of CHE and improved health-related quality of life in adults with moderate to severe disease; efficacy was maintained with as-needed treatment in a subsequent 36-week open-label extension study. Moreover, an active-controlled trial demonstrated that delgocitinib 20 mg/g cream had superior efficacy and apparent improved tolerability versus oral alitretinoin in adults with severe CHE. Delgocitinib 20 mg/g cream was well tolerated locally in clinical trials, with low systemic exposure with topical application. In summary, current data show that delgocitinib 20 mg/g cream is an efficacious and well tolerated treatment for moderate to severe CHE in adults. As the first topical treatment specifically approved for CHE, it presents a valuable new non-steroidal option in patients for whom topical corticosteroids are inadequate or inappropriate.
Abstract
Journal Article
Review
eng
40658334
McGuigan, Aisling, and Matt Shirley. "Delgocitinib 20 Mg/g Cream: a Review in Chronic Hand Eczema." Drugs, vol. 85, no. 9, 2025, pp. 1153-1162.
McGuigan A, Shirley M. Delgocitinib 20 mg/g Cream: A Review in Chronic Hand Eczema. Drugs. 2025;85(9):1153-1162.
McGuigan, A., & Shirley, M. (2025). Delgocitinib 20 mg/g Cream: A Review in Chronic Hand Eczema. Drugs, 85(9), 1153-1162. https://doi.org/10.1007/s40265-025-02206-9
McGuigan A, Shirley M. Delgocitinib 20 Mg/g Cream: a Review in Chronic Hand Eczema. Drugs. 2025;85(9):1153-1162. PubMed PMID: 40658334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Delgocitinib 20 mg/g Cream: A Review in Chronic Hand Eczema.
AU - McGuigan,Aisling,
AU - Shirley,Matt,
Y1 - 2025/07/14/
PY - 2025/06/18/accepted
PY - 2025/9/6/medline
PY - 2025/7/14/pubmed
PY - 2025/7/14/entrez
SP - 1153
EP - 1162
JF - Drugs
JO - Drugs
VL - 85
IS - 9
N2 - Delgocitinib is a pan-Janus kinase (JAK) inhibitor that targets all four JAK isoforms. Delgocitinib 20 mg/g cream (Anzupgo[®] 20 mg/g), a non-steroidal therapy, is the first topical treatment indicated in the EU for moderate to severe chronic hand eczema (CHE) in adults for whom topical corticosteroids are inadequate or inappropriate. In two 16-week, double-blind, vehicle-controlled, multinational phase III trials, twice-daily delgocitinib 20 mg/g cream improved the signs and symptoms of CHE and improved health-related quality of life in adults with moderate to severe disease; efficacy was maintained with as-needed treatment in a subsequent 36-week open-label extension study. Moreover, an active-controlled trial demonstrated that delgocitinib 20 mg/g cream had superior efficacy and apparent improved tolerability versus oral alitretinoin in adults with severe CHE. Delgocitinib 20 mg/g cream was well tolerated locally in clinical trials, with low systemic exposure with topical application. In summary, current data show that delgocitinib 20 mg/g cream is an efficacious and well tolerated treatment for moderate to severe CHE in adults. As the first topical treatment specifically approved for CHE, it presents a valuable new non-steroidal option in patients for whom topical corticosteroids are inadequate or inappropriate.
SN - 1179-1950
UR - https://www.unboundmedicine.com/prime/citation/40658334/Delgocitinib_20_mg_g_Cream:_A_Review_in_Chronic_Hand_Eczema.
DB - PRIME
DP - Unbound Medicine
ER -
