Breast-implant associated unicentric castleman disease: a case report.
Curr Probl Cancer Case Rep 2026 Mar; 21.

Abstract

ALK-negative anaplastic large cell lymphoma is a well-established hematologic complication of prosthetic breast implantation, but other rare conditions should also be considered. We report a case of a 36-year-old female with bilateral retropectoral breast implants since age 20 who presented with fatigue, lower extremity edema, fevers, and a slowly growing left breast mass. Ultrasound of the left breast revealed a 6 × 6 cm left upper quadrant mass. Surgical excision identified pathologic features consistent with hyaline-vascular unicentric Castleman disease (UCD). This is the first case of breast-implant associated UCD, expanding the differential diagnosis for masses associated with prosthetic breast implantation.

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Authors+Show Affiliations

Shyamsundar SCenter for Cytokine Storm Treatment & Laboratory, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Bustamante MSCenter for Cytokine Storm Treatment & Laboratory, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Borys LCenter for Cytokine Storm Treatment & Laboratory, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lim MSDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
Bagg ADepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lechowicz MJDepartment of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA.
Alapat DDepartment of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Chadburn ADivision of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Srkalovic GUniversity of Michigan Health-Sparrow Herbert-Herman Cancer Center, Lansing, MI, USA.
van Rhee FMyeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Austin BCenter for Cytokine Storm Treatment & Laboratory, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Brandstadter JDCenter for Cytokine Storm Treatment & Laboratory, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Fajgenbaum DCCenter for Cytokine Storm Treatment & Laboratory, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

41836733