Venom Anaphylaxis.
Immunol Allergy Clin North Am 2026 May; 46(2):325-345.

Abstract

Allergy to venoms of stinging insects (bees, yellow jackets, hornets, wasps, and stinging ants) causes large local reactions or systemic reactions, including anaphylaxis. Diagnostic evaluation includes skin testing and/or serum venom-specific IgE and basal serum tryptase (to identify underlying mast cell disorders). Patients with sting anaphylaxis should be prescribed epinephrine and venom immunotherapy which prevents allergic reactions in up to 98% of patients. Most patients may safely discontinue venom immunotherapy after 5 years, although high-risk patients need to continue indefinitely. Further research is needed to improve the predictive value of diagnostic testing and the safety and efficacy of treatment.

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Publisher Full Text (DOI)

Authors+Show Affiliations

McMurray JCDepartment of Allergy and Immunology, Walter Reed National Military Medical Center, 4954 North Palmer Road, Bethesda, MD 20889, USA; Department of Pediatrics, Uniformed Services University, 4954 North Palmer Road, Bethesda, MD 20889 USA. Electronic address: jeremymcmurray@gmail.com.
Bingemann TADivision of Allergy, Immunology and Rheumatology, University of Rochester, 601 Elmwood Avenue, Box 695, Rochester, NY 14642, USA; Division of Pediatric Allergy and Immunology, University of Rochester, Rochester, NY 14642, USA.
Golden DBKDivision of Allergy and Clinical Immunology, Johns Hopkins School of Medicine, 5500 Hopkins Bayview Circle, Baltimore, MD 21224, USA.

MeSH

HumansAnaphylaxisAnimalsInsect Bites and StingsArthropod VenomsImmunoglobulin EAllergensDesensitization, ImmunologicEpinephrineTryptasesSkin Tests

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

41932750