Hypertensive nephropathy (HN) is a leading cause of chronic kidney disease and end-stage renal disease worldwide and results from the long-term effects of hypertension on renal structure and function. The pathogenesis of HN is complex and involves haemodynamic disturbances, renal vascular injury, oxidative stress, chronic inflammation, and progressive interstitial fibrosis. In recent years, increasing attention has focused on the role of non-coding RNAs (ncRNAs)-including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs)-as key regulators of gene expression involved in these processes. This review summarises the current understanding of the molecular mechanisms underlying HN, with particular emphasis on the roles of oxidative stress, activation of the renin-angiotensin-aldosterone system, transforming growth factor beta signalling, and inflammatory and fibrogenic pathways. The contribution of dysregulated ncRNAs to endothelial dysfunction, inflammatory responses, apoptosis, angiogenesis, and renal remodelling and fibrosis is also discussed. Particular attention is given to miRNAs and lncRNAs as mediators of disease progression and potential biomarkers, as well as to the emerging role of circRNAs in hypertensive kidney injury, including their involvement in the regulation of redox balance and intercellular communication. Collectively, available evidence indicates that ncRNAs represent a critical link between haemodynamic stimuli and persistent molecular alterations in renal tissue, highlighting their potential as diagnostic markers and therapeutic targets in HN.
Abstract
Journal Article
Review
eng
42041569
Plewa, Paulina, et al. "The Role of Non-Coding RNA in the Pathogenesis of Hypertensive Nephropathy." Cells, vol. 15, no. 8, 2026.
Plewa P, Figiel K, Ćmil M, et al. The Role of Non-Coding RNA in the Pathogenesis of Hypertensive Nephropathy. Cells. 2026;15(8).
Plewa, P., Figiel, K., Ćmil, M., Skórka, P., Kupis, K., & Pawlik, A. (2026). The Role of Non-Coding RNA in the Pathogenesis of Hypertensive Nephropathy. Cells, 15(8). https://doi.org/10.3390/cells15080701
Plewa P, et al. The Role of Non-Coding RNA in the Pathogenesis of Hypertensive Nephropathy. Cells. 2026 Apr 15;15(8) PubMed PMID: 42041569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - The Role of Non-Coding RNA in the Pathogenesis of Hypertensive Nephropathy.
AU - Plewa,Paulina,
AU - Figiel,Karolina,
AU - Ćmil,Maciej,
AU - Skórka,Patryk,
AU - Kupis,Kacper,
AU - Pawlik,Andrzej,
Y1 - 2026/04/15/
PY - 2026/03/08/received
PY - 2026/04/02/revised
PY - 2026/04/11/accepted
PY - 2026/4/27/medline
PY - 2026/4/27/pubmed
PY - 2026/4/27/entrez
KW - circular RNA
KW - hypertensive nephropathy
KW - long non-coding RNA
KW - microRNA
KW - non-coding RNA
JF - Cells
JO - Cells
VL - 15
IS - 8
N2 - Hypertensive nephropathy (HN) is a leading cause of chronic kidney disease and end-stage renal disease worldwide and results from the long-term effects of hypertension on renal structure and function. The pathogenesis of HN is complex and involves haemodynamic disturbances, renal vascular injury, oxidative stress, chronic inflammation, and progressive interstitial fibrosis. In recent years, increasing attention has focused on the role of non-coding RNAs (ncRNAs)-including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs)-as key regulators of gene expression involved in these processes. This review summarises the current understanding of the molecular mechanisms underlying HN, with particular emphasis on the roles of oxidative stress, activation of the renin-angiotensin-aldosterone system, transforming growth factor beta signalling, and inflammatory and fibrogenic pathways. The contribution of dysregulated ncRNAs to endothelial dysfunction, inflammatory responses, apoptosis, angiogenesis, and renal remodelling and fibrosis is also discussed. Particular attention is given to miRNAs and lncRNAs as mediators of disease progression and potential biomarkers, as well as to the emerging role of circRNAs in hypertensive kidney injury, including their involvement in the regulation of redox balance and intercellular communication. Collectively, available evidence indicates that ncRNAs represent a critical link between haemodynamic stimuli and persistent molecular alterations in renal tissue, highlighting their potential as diagnostic markers and therapeutic targets in HN.
SN - 2073-4409
UR - https://www.unboundmedicine.com/prime/citation/42041569/The_Role_of_Non-Coding_RNA_in_the_Pathogenesis_of_Hypertensive_Nephropathy.
DB - PRIME
DP - Unbound Medicine
ER -
