iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025.
Heart Views 2025 Oct-Dec; 26(4):227-259.

Abstract

Inconsistencies in healthcare access, varying infrastructure, resource constraints and diverse local practices as well as practical and political issues restrict the global applicability of currently available guidelines. There is a need for universal recommen- dations that address the unique challenges faced by patients and healthcare providers worldwide. Our iCARDIO Alliance Global Implementation Guidelines emphasize the incorporation of novel therapies, while integrating standard of care with the most up-to-date evidence to enable clinicians to optimize patient care. This document is about heart failure (HF), including acute and chronic heart failure, heart failure with reduced ejection fraction and heart failure with preserved ejection fraction as well as cardiomyopathies. Context-specific recommendations tailored to individual patient needs are highlighted providing a thorough evaluation of the risks, benefits, and overall value of each therapy, aiming to establish a standard of care that improves patient outcomes and reduces the burden of hospitalization in this susceptible population. These guidelines provide evidence-based recommendations that represent a group consensus considering the many other published guidelines that have reviewed many of the issues discussed here, but they also make new recommendations where new evidence has recently emerged. Most importantly these guidelines also provide recommendations on a number of issues where resource limitations may put constraints on the care provided to HF patients. Such "economic adjustment" recommendations aim to provide guidance for situations when "Resources are somewhat limited" or when "Resources are severely limited". Hence, this document presents not only a comprehensive but also concise update to HF management guidelines thereby aiming to provide a unified strategy for the pharmacological, non-pharmacological, invasive and interventional management of this significant global health challenge that is applicable to the needs of healthcare around the globe.

Authors+Show Affiliations

Chopra VHeart Failure Programme and Research, Max Super Specialty Hospital, Saket, New Delhi, India.
Khan MSBaylor Scott and White Research Institute, Dallas, TX - Baylor Scott and White Health, The Heart Hospital, Plano, TX, USA.
Abdelhamid MFaculty of Medicine, Cairo University, Cairo, Egypt.
Abraham WTDivision of Cardiovascular Medicine and The Davis Heart and Vascular Research Institute, The Ohio State University (OSU) College of Medicine and OSU Wexner Medical Center, Columbus, OH, USA.
Amir OHeart Institute, Hadassah Medical Center & Hebrew University, Jerusalem, Israel.
Anker SDDepartment of Cardiology (CVK) of German Heart Center Charité German Centre for Cardiovascular Research (DZHK) partner site Berlin, Charité Universitätsmedizin, Berlin, Germany.
Atherton JJUniversity of Queensland Faculty of Medicine, Cardiology Department, Royal Brisbane and Women's Hospital, Herston, Brisbane, QLD, Australia.
Bacal FHeart Institute (InCor), Medical School, University of Sao Paulo; Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
von Bardeleben RSDepartment of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Brito DCardiology Department, ULSSM, Hospital de Santa Maria, CCUL@RISE, Lisboa, Portugal.
Burgos LMHeart Failure, Pulmonary Hypertension and Heart Transplantation Department, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina.
Butler JDepartment of Medicine, University of Mississippi Medical Centre, Jackson, MS and Baylor Scott and White Research Institute, Dallas, TX, USA.
Costanzo MRMidwest Cardiovascular Institute, Naperville, IL, USA.
Damasceno AFaculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
Ezekowitz JAUniversity of Alberta, Edmonton, Canada.
Hameed IDepartment of Medicine, MedStar Health, Baltimore, MD, USA.
Harikrishnan SDepartment of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.
Jaarsma TDepartment of Health, Medicine and Caring Sciences, Linköping University, Sweden.
Lala AMount Sinai Fuster Heart Hospital, Icahn School of Medicine, New York, NY, USA.
Piña ILThomas Jefferson University, Philadelphia, PA, USA.
Saldarriaga CClinica CardioVID, University of Antioquia, Medellin, Colombia.
Sim DNational Heart Centre Singapore, Singapore.
Teerlink JRSection of Cardiology, San Francisco Veterans Affairs Medical Center, San Francisco and School of Medicine, University of California San Francisco, San Francisco, CA, USA.
Tsabedze NDivision of Cardiology, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand and the Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa.
Tsutsui HInternational University of Health and Welfare, Fukuoka, Japan.
Yu JHeart Failure Center, Department of Cardiology, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Zhang YHeart Failure Center, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zubaid MDepartment of Medicine, Faculty of Medicine, Kuwait University, Kuwait.
Balankhe NDepartment of Medicine and Critical Care Medicine, Viveka Hospitals, Nagpur, Maharashtra, India.
Gomez-Mesa JEServicio de Cardiología, Fundación Valle del Lili, Cali - Departamento de Ciencias de la Salud, Universidad Icesi, Cali, Colombia.
Januzzi JLDivision of Cardiology, Massachusetts General Hospital, Harvard Medical School, Baim Institute for Clinical Research, Boston, MA, USA.
Konstam MTufts Medical Center, Boston, MA, USA.
Monroe RBetter Outcomes Optimal Scientific Therapies (BOOST), Washington D.C., USA.
Ogola EDepartment of Clinical Medicine and Therapeutics, Faculty of Health Sciences, University of Nairobi, Kenya.
Palaniappan VDr. V. Palaniyappen's Diabetes Specialities Centre, Near Bus Stand, Guziliamparai, Dindigul (Dt), Tamil Nadu, India.
Petrie MCSchool of Cardiovascular and Metabolic Health, University of Glasgow, British Heart Foundation Glasgow Cardiovascular Research Centre, Glasgow, UK.
Pinto FJCentro Academico de Medicina de Lisboa, CCUL@RISE, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
Rajadhyaksha GCDepartment of Medicine, Topiwala National Medical College & B.Y.L. Nair Ch Hospital, Mumbai, Maharashtra, India.
Rakisheva ACardiology Department, City Cardiology Center, Almaty, Kazakhstan.
Ramos CEInstituto Nacional Cardiopulmonar, Tegucigalpa, Honduras.
Rossel VCouncil of Heart Failure and Pulmonary Hypertension, Inter-American Society of Cardiology, México; Hospital del Salvador/Faculty of Medicine, University of Chile, Santiago, Chile.
Sato NDepartment of Cardiovascular Medicine, Kawaguchi Cardiovascular and Respiratory Hospital, Kawaguchi, Japan.
Schulze PCDepartment of Internal Medicine I, Cardiology, University Hospital Jena, Jena, Germany.
Sindone AHeart Failure Unit and Department of Cardiac Rehabilitation, Concord Hospital and Department of Cardiology, Ryde Hospital, Sydney, Australia.
Skouri HNCardiology Division, Balamand University Faculty of Medicine and Medical Sciences, Beirut, Lebanon; Cardiology Division, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates.
Van Spall HGCDepartment of Medicine, Department of Health Research Methods Evidence, and Impact, Population Health Research Institute, McMaster University Hamilton, Ontario, Canada.
Štaraitė AGlobal Heart Hub, The International Alliance of Heart Patient Organisations, Lithuania/Ireland.
Stevenson LWVanderbilt University Medical School, Nashville, TN, USA.
Sulaiman KNational Heart Center, Royal Hospital, Muscat, Oman.
Wang TDCardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei City, Taiwan.
Böhm MUniversitätsklinikum des Saarlandes, HOMICAREM (HOMburg Institute for CArdioREnalMetabolic Medicine), Klinik für Innere Medizin III, Saarland University, Homburg/Saar, Germany.
Coats AJSHeart Research Institute, Sydney, Australia.
Zieroth SUniversity of Manitoba, St. Boniface Hospital, Cardiac Sciences Manitoba, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

42094120