Updates on Von Willebrand Disease Testing.Clin Lab Med 2026 Jun; 46(2):153-165.CL
Abstract
von Willebrand Disease (VWD) is the most common heritable bleeding disorder worldwide and arises from quantitative or qualitative deficiencies of von Willebrand Factor (VWF). VWF is a multimeric protein essential for primary hemostasis and factor VIII stabilization. Diagnosis of VWD requires integration of bleeding history and laboratory testing. Traditional laboratory assays, such as ristocetin cofactor activity (VWF:RCo) are increasingly being replaced by newer methods with improved analytical performance, including VWF:GPIbM and VWF:GPIbR. Advances in multimer analysis, Collagen Binding, and genetic testing are further refining the approach to VWD subtype classification. This review summarizes recent diagnostic innovations.
Pub Type(s)
Journal Article
Review
Language
eng
PubMed ID
42140677
Citation
Salazar, Eric, and Russell A. Higgins. "Updates On Von Willebrand Disease Testing." Clinics in Laboratory Medicine, vol. 46, no. 2, 2026, pp. 153-165.
Salazar E, Higgins RA. Updates on Von Willebrand Disease Testing. Clin Lab Med. 2026;46(2):153-165.
Salazar, E., & Higgins, R. A. (2026). Updates on Von Willebrand Disease Testing. Clinics in Laboratory Medicine, 46(2), 153-165. https://doi.org/10.1016/j.cll.2026.02.001
Salazar E, Higgins RA. Updates On Von Willebrand Disease Testing. Clin Lab Med. 2026;46(2):153-165. PubMed PMID: 42140677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Updates on Von Willebrand Disease Testing.
AU - Salazar,Eric,
AU - Higgins,Russell A,
Y1 - 2026/03/24/
PY - 2026/5/16/medline
PY - 2026/5/16/pubmed
PY - 2026/5/15/entrez
KW - Coagulation testing
KW - Laboratory testing
KW - Von Willebrand disease
SP - 153
EP - 165
JF - Clinics in laboratory medicine
JO - Clin Lab Med
VL - 46
IS - 2
N2 - von Willebrand Disease (VWD) is the most common heritable bleeding disorder worldwide and arises from quantitative or qualitative deficiencies of von Willebrand Factor (VWF). VWF is a multimeric protein essential for primary hemostasis and factor VIII stabilization. Diagnosis of VWD requires integration of bleeding history and laboratory testing. Traditional laboratory assays, such as ristocetin cofactor activity (VWF:RCo) are increasingly being replaced by newer methods with improved analytical performance, including VWF:GPIbM and VWF:GPIbR. Advances in multimer analysis, Collagen Binding, and genetic testing are further refining the approach to VWD subtype classification. This review summarizes recent diagnostic innovations.
SN - 1557-9832
UR - https://www.unboundmedicine.com/prime/citation/42140677/Updates_on_Von_Willebrand_Disease_Testing.
DB - PRIME
DP - Unbound Medicine
ER -
