Cold agglutinin disease.
Br J Haematol 2026 Aug; 209(2):444-447.

Abstract

Cold agglutinin disease is an autoimmune haemolytic anaemia related to a clonal B-cell disorder of the bone marrow. Haemolysis is complement-dependent, while acrocyanosis is monoclonal agglutinin-dependent. Established therapies target the clonal B cells or the classical complement pathway. Treatment can be tailored based on clinical phenotypes.

Authors+Show Affiliations

Berentsen S0000-0002-3425-4653Department of Research and Innovation, Haugesund Hospital, Helse Fonna HF, Haugesund, Norway.
Vos JMI0000-0003-3229-9556Department of Hematology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. Sanquin Research, Amsterdam, the Netherlands.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

42144314