Effect of premixed and sequential intrathecal fentanyl on spinal block characteristics.Bioinformation 2026; 22(3):1769-1772.B
Abstract
The optimal method of intrathecal fentanyl administration with hyperbaric bupivacaine remains uncertain, as premixed and sequential techniques may influence block characteristics differently. In this prospective observational comparative study, 42 ASA I-II adults (21 per group) received fentanyl 0.5 ml with hyperbaric bupivacaine 2.5 ml either premixed or sequentially. Sequential administration produced faster sensory onset at T10 (5.00±1.37 vs 6.48±1.32 min) and motor onset (6.10±1.37 vs 8.00±1.30 min) with longer sensory and motor regression times. Time to first rescue analgesia was also longer (205.33±12.08 vs 175.38±14.41 min), suggesting earlier onset and prolonged block with the sequential technique.
Links
Pub Type(s)
Journal Article
Language
eng
PubMed ID
42145407
Citation
Gupta, Priyanka, et al. "Effect of Premixed and Sequential Intrathecal Fentanyl On Spinal Block Characteristics." Bioinformation, vol. 22, no. 3, 2026, pp. 1769-1772.
Gupta P, Sharma U, Gupta D, et al. Effect of premixed and sequential intrathecal fentanyl on spinal block characteristics. Bioinformation. 2026;22(3):1769-1772.
Gupta, P., Sharma, U., Gupta, D., Bansal, L., & Jain, P. (2026). Effect of premixed and sequential intrathecal fentanyl on spinal block characteristics. Bioinformation, 22(3), 1769-1772. https://doi.org/10.6026/973206300221769
Gupta P, et al. Effect of Premixed and Sequential Intrathecal Fentanyl On Spinal Block Characteristics. Bioinformation. 2026;22(3):1769-1772. PubMed PMID: 42145407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Effect of premixed and sequential intrathecal fentanyl on spinal block characteristics.
AU - Gupta,Priyanka,
AU - Sharma,Utsav,
AU - Gupta,Deepak,
AU - Bansal,Lokesh,
AU - Jain,Payal,
Y1 - 2026/03/31/
PY - 2026/3/1/received
PY - 2026/3/31/revised
PY - 2026/3/31/accepted
PY - 2026/5/18/medline
PY - 2026/5/18/pubmed
PY - 2026/5/18/entrez
PY - 2026/3/31/pmc-release
KW - Intrathecal fentanyl
KW - Sequential technique
KW - Spinal anaesthesia
KW - hyperbaric bupivacaine
KW - premixed technique
KW - subarachnoid block
SP - 1769
EP - 1772
JF - Bioinformation
JO - Bioinformation
VL - 22
IS - 3
N2 - The optimal method of intrathecal fentanyl administration with hyperbaric bupivacaine remains uncertain, as premixed and sequential techniques may influence block characteristics differently. In this prospective observational comparative study, 42 ASA I-II adults (21 per group) received fentanyl 0.5 ml with hyperbaric bupivacaine 2.5 ml either premixed or sequentially. Sequential administration produced faster sensory onset at T10 (5.00±1.37 vs 6.48±1.32 min) and motor onset (6.10±1.37 vs 8.00±1.30 min) with longer sensory and motor regression times. Time to first rescue analgesia was also longer (205.33±12.08 vs 175.38±14.41 min), suggesting earlier onset and prolonged block with the sequential technique.
SN - 0973-2063
UR - https://www.unboundmedicine.com/prime/citation/42145407/Effect_of_premixed_and_sequential_intrathecal_fentanyl_on_spinal_block_characteristics.
DB - PRIME
DP - Unbound Medicine
ER -
