Leukemia cutis is an uncommon extramedullary manifestation of acute myeloid leukemia (AML) caused by infiltration of the skin by leukemic blasts. Its clinical morphology is highly variable and may mimic infectious, inflammatory, or other neoplastic dermatoses, making tissue diagnosis essential. We report a 49-year-old man who presented with fever, epistaxis, and multifocal nodular and ulcerated skin lesions involving the right wrist, chest, and scalp, as well as gingival hyperplasia. Skin biopsy was reported to confirm cutaneous myeloid sarcoma, consistent with leukemia cutis in the setting of AML. Histopathology demonstrated dense dermal infiltration by atypical myeloid cells with relative epidermal sparing. The patient was diagnosed with AML with cutaneous involvement and was started on systemic chemotherapy. This case emphasizes the importance of early biopsy of suspicious skin lesions in patients with known or suspected hematologic malignancy and highlights the adverse prognostic implications of leukemia cutis.
Abstract
Case Reports
Journal Article
eng
42147687
Saied, Amin Saied Sanosi, et al. "Leukemia Cutis in Acute Myeloid Leukemia: a Case Report." Cureus, vol. 18, no. 4, 2026, pp. e107112.
Saied ASS, Almahmood M, Al-Mashdali A, et al. Leukemia Cutis in Acute Myeloid Leukemia: A Case Report. Cureus. 2026;18(4):e107112.
Saied, A. S. S., Almahmood, M., Al-Mashdali, A., Tariq, M. A., & Yassin, M. (2026). Leukemia Cutis in Acute Myeloid Leukemia: A Case Report. Cureus, 18(4), e107112. https://doi.org/10.7759/cureus.107112
Saied ASS, et al. Leukemia Cutis in Acute Myeloid Leukemia: a Case Report. Cureus. 2026;18(4):e107112. PubMed PMID: 42147687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Leukemia Cutis in Acute Myeloid Leukemia: A Case Report.
AU - Saied,Amin Saied Sanosi,
AU - Almahmood,Motaz,
AU - Al-Mashdali,Abdulrahman,
AU - Tariq,Muhammad Ali,
AU - Yassin,Mohamed,
Y1 - 2026/04/15/
PY - 2026/4/15/accepted
PY - 2026/5/18/medline
PY - 2026/5/18/pubmed
PY - 2026/5/18/entrez
PY - 2026/4/15/pmc-release
KW - acute myeloid leukemia (aml)
KW - cutaneous myeloid sarcoma
KW - gingival hyperplasia
KW - leukemia cutis
KW - myeloid sarcoma
KW - skin biopsy
SP - e107112
EP - e107112
JF - Cureus
JO - Cureus
VL - 18
IS - 4
N2 - Leukemia cutis is an uncommon extramedullary manifestation of acute myeloid leukemia (AML) caused by infiltration of the skin by leukemic blasts. Its clinical morphology is highly variable and may mimic infectious, inflammatory, or other neoplastic dermatoses, making tissue diagnosis essential. We report a 49-year-old man who presented with fever, epistaxis, and multifocal nodular and ulcerated skin lesions involving the right wrist, chest, and scalp, as well as gingival hyperplasia. Skin biopsy was reported to confirm cutaneous myeloid sarcoma, consistent with leukemia cutis in the setting of AML. Histopathology demonstrated dense dermal infiltration by atypical myeloid cells with relative epidermal sparing. The patient was diagnosed with AML with cutaneous involvement and was started on systemic chemotherapy. This case emphasizes the importance of early biopsy of suspicious skin lesions in patients with known or suspected hematologic malignancy and highlights the adverse prognostic implications of leukemia cutis.
SN - 2168-8184
UR - https://www.unboundmedicine.com/prime/citation/42147687/Leukemia_Cutis_in_Acute_Myeloid_Leukemia:_A_Case_Report.
DB - PRIME
DP - Unbound Medicine
ER -
