Abstract
Optical imaging offers a high potential for noninvasive detection and therapy of cancer in humans. Recent advances in instrumentation for diffuse optical imaging have led to new capabilities for the detection of cancer in highly scattering tissue such as the female breast. In particular, fluorescence imaging is a promising method to image molecular probes in vivo. We review recent developments in the detection of breast cancer and fluorescence-guided surgery of the breast by contrast agents available for application on humans. Detection of cancer has been investigated with the unspecific contrast agents "indocyanine green" and "omocianine" so far. Hereby, indocyanine green was found to offer high potential for the differentiation of malignant and benign lesions by exploiting vessel permeability for macromolecules as a cancer-specific feature. Tumor-specific molecular targeting and activatable probes have been investigated in clinical trials for fluorescence-guided detection of tumor margins. In this application, high spatial resolution can be achieved, since tumor regions are visualized mainly at the tissue surface. As another example of superficial tumor tissue, imaging of lesions in the gastrointestinal tract is discussed. Promising results have been obtained on high-risk patients with Barrett's esophagus and with ulcerative colitis by administering 5-aminolevulinic acid, which induces the accumulation of protoporphyrin IX serving as a tumor-specific fluorescent marker. Time-gated fluorescence imaging and spectroscopy are effective ways to suppress the underlying background from tissue autofluorescence. Furthermore, recently developed tumor-specific molecular probes have been demonstrated to be superior to white-light endoscopy, offering new ways for early detection of malignancies in the gastrointestinal tract.
TY - JOUR
T1 - Fluorescence Imaging of Cancer.
A1 - Grosenick,Dirk,
PY - 2026/5/21/medline
PY - 2026/5/21/pubmed
PY - 2026/5/21/entrez
KW - Breast cancer
KW - Colon cancer
KW - Dysplasia
KW - Esophageal cancer
KW - Fluorescence endoscopy
KW - Fluorescence imaging of cancer
KW - Fluorescence-guided surgery
KW - Optical molecular imaging
SP - 643
EP - 672
JF - Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
JO - Recent Results Cancer Res
VL - 225
N2 - Optical imaging offers a high potential for noninvasive detection and therapy of cancer in humans. Recent advances in instrumentation for diffuse optical imaging have led to new capabilities for the detection of cancer in highly scattering tissue such as the female breast. In particular, fluorescence imaging is a promising method to image molecular probes in vivo. We review recent developments in the detection of breast cancer and fluorescence-guided surgery of the breast by contrast agents available for application on humans. Detection of cancer has been investigated with the unspecific contrast agents "indocyanine green" and "omocianine" so far. Hereby, indocyanine green was found to offer high potential for the differentiation of malignant and benign lesions by exploiting vessel permeability for macromolecules as a cancer-specific feature. Tumor-specific molecular targeting and activatable probes have been investigated in clinical trials for fluorescence-guided detection of tumor margins. In this application, high spatial resolution can be achieved, since tumor regions are visualized mainly at the tissue surface. As another example of superficial tumor tissue, imaging of lesions in the gastrointestinal tract is discussed. Promising results have been obtained on high-risk patients with Barrett's esophagus and with ulcerative colitis by administering 5-aminolevulinic acid, which induces the accumulation of protoporphyrin IX serving as a tumor-specific fluorescent marker. Time-gated fluorescence imaging and spectroscopy are effective ways to suppress the underlying background from tissue autofluorescence. Furthermore, recently developed tumor-specific molecular probes have been demonstrated to be superior to white-light endoscopy, offering new ways for early detection of malignancies in the gastrointestinal tract.
SN - 0080-0015
UR - https://www.unboundmedicine.com/prime/citation/42165826/Fluorescence_Imaging_of_Cancer.
DB - PRIME
DP - Unbound Medicine
ER -
