Host Variation in Pneumonia Susceptibility.Clin Chest Med 2026 Jun; 47(2):185-197.CC
Abstract
Infectious pneumonias affect millions of individuals annually worldwide, accounting for unacceptably high mortalities in many populations. Following pathogen introduction to the lower respiratory tract by inhalation or aspiration, complex interactions between the host and the microbe determine whether the microbe is cleared or establishes an infectious pneumonia. Even modest variations in the host immune response to pathogens may have potentially profound impacts on pathogenesis, severity, and eventual survival of infectious pneumonias. In this article, the authors summarize the most common conditions that alter host defenses in a manner that predisposes to development of pneumonia.
MeSH
Pub Type(s)
Journal Article
Review
Language
eng
PubMed ID
42203412
Citation
Box, Nathan R., et al. "Host Variation in Pneumonia Susceptibility." Clinics in Chest Medicine, vol. 47, no. 2, 2026, pp. 185-197.
Box NR, Pantaleón García J, Evans SE. Host Variation in Pneumonia Susceptibility. Clin Chest Med. 2026;47(2):185-197.
Box, N. R., Pantaleón García, J., & Evans, S. E. (2026). Host Variation in Pneumonia Susceptibility. Clinics in Chest Medicine, 47(2), 185-197. https://doi.org/10.1016/j.ccm.2025.12.003
Box NR, Pantaleón García J, Evans SE. Host Variation in Pneumonia Susceptibility. Clin Chest Med. 2026;47(2):185-197. PubMed PMID: 42203412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Host Variation in Pneumonia Susceptibility.
AU - Box,Nathan R,
AU - Pantaleón García,Jezreel,
AU - Evans,Scott E,
Y1 - 2026/02/04/
PY - 2026/5/28/medline
PY - 2026/5/28/pubmed
PY - 2026/5/27/entrez
KW - Biological therapies
KW - Hematologic malignancy
KW - Host variation
KW - Human immunodeficiency virus
KW - Immunocompromised host
KW - Neutropenia
KW - Pneumonia
KW - Transplant
SP - 185
EP - 197
JF - Clinics in chest medicine
JO - Clin Chest Med
VL - 47
IS - 2
N2 - Infectious pneumonias affect millions of individuals annually worldwide, accounting for unacceptably high mortalities in many populations. Following pathogen introduction to the lower respiratory tract by inhalation or aspiration, complex interactions between the host and the microbe determine whether the microbe is cleared or establishes an infectious pneumonia. Even modest variations in the host immune response to pathogens may have potentially profound impacts on pathogenesis, severity, and eventual survival of infectious pneumonias. In this article, the authors summarize the most common conditions that alter host defenses in a manner that predisposes to development of pneumonia.
SN - 1557-8216
UR - https://www.unboundmedicine.com/prime/citation/42203412/Host_Variation_in_Pneumonia_Susceptibility.
DB - PRIME
DP - Unbound Medicine
ER -
