Pathophysiology of Cough.Otolaryngol Clin North Am 2026 May 27. [Online ahead of print]OC
Abstract
Cough pathophysiology ranges from a simple reflex to a complex neuroimmune disorder involving intricate neural circuitry, peripheral sensitization, and central plasticity. The cough reflex is governed by a complex orchestration of sensory nerves and central brain structures. Chronic cough often results from peripheral and central sensitization, leading to hypersensitivity influenced by various physiologic and environmental factors. This advanced understanding is vital for developing personalized, mechanism-directed therapies for this prevalent condition.
Pub Type(s)
Journal Article
Review
Language
eng
PubMed ID
42203561
Citation
Giannaris, Peter S., and Seth E. Kaplan. "Pathophysiology of Cough." Otolaryngologic Clinics of North America, 2026.
Giannaris PS, Kaplan SE. Pathophysiology of Cough. Otolaryngol Clin North Am. 2026.
Giannaris, P. S., & Kaplan, S. E. (2026). Pathophysiology of Cough. Otolaryngologic Clinics of North America. https://doi.org/10.1016/j.otc.2026.04.003
Giannaris PS, Kaplan SE. Pathophysiology of Cough. Otolaryngol Clin North Am. 2026 May 27; PubMed PMID: 42203561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Pathophysiology of Cough.
AU - Giannaris,Peter S,
AU - Kaplan,Seth E,
Y1 - 2026/05/27/
PY - 2026/5/28/medline
PY - 2026/5/28/pubmed
PY - 2026/5/27/entrez
KW - Chronic cough
KW - Cough hypersensitivity syndrome
KW - Neuroimmune interactions
KW - P2X3 receptors
KW - Vagal afferents
JF - Otolaryngologic clinics of North America
JO - Otolaryngol Clin North Am
N2 - Cough pathophysiology ranges from a simple reflex to a complex neuroimmune disorder involving intricate neural circuitry, peripheral sensitization, and central plasticity. The cough reflex is governed by a complex orchestration of sensory nerves and central brain structures. Chronic cough often results from peripheral and central sensitization, leading to hypersensitivity influenced by various physiologic and environmental factors. This advanced understanding is vital for developing personalized, mechanism-directed therapies for this prevalent condition.
SN - 1557-8259
UR - https://www.unboundmedicine.com/prime/citation/42203561/Pathophysiology_of_Cough.
DB - PRIME
DP - Unbound Medicine
ER -
