TY - JOUR T1 - Drug Induced Liver Injury in Children: Practical Considerations for Pathologists. AU - Patel,Kalyani R, AU - Putra,Juan, Y1 - 2026/06/09/ PY - 2026/6/9/medline PY - 2026/6/9/pubmed PY - 2026/6/9/entrez KW - Lafora-like inclusions KW - acute cholestasis KW - drugs KW - hepatitis KW - vanishing bile duct syndrome SP - 10935266261458421 EP - 10935266261458421 JF - Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society JO - Pediatr Dev Pathol N2 - Drug-induced liver injury (DILI) in children remains a diagnostic challenge due to its broad clinical and histologic spectrum. Based on pathogenesis, DILI is classified as idiosyncratic, intrinsic (direct), or indirect. In the United States, antimicrobials and antiepileptic medications are the most commonly implicated agents. Because histologic features are often nonspecific, diagnosis and assessment of causality rely on clinicopathologic correlation. Although not always required, liver biopsy can aid in characterizing injury patterns, assessing severity, and excluding mimickers. This review highlights the major morphologic patterns of pediatric DILI, associated agents, and practical considerations for biopsy interpretation in routine practice. SN - 1615-5742 UR - https://www.unboundmedicine.com/prime/citation/42262030/Drug_Induced_Liver_Injury_in_Children:_Practical_Considerations_for_Pathologists. DB - PRIME DP - Unbound Medicine ER -