Recurrent falls while taking clozapine.
Pract Neurol 2026 Jun 30. [Online ahead of print]

Abstract

A 56-year-old man developed frequent falls after starting clozapine for treatment-resistant bipolar disorder. His falls were caused by negative myoclonus (see videos)-a rare adverse effect of clozapine. His movement disorder persisted despite adding antiseizure medication (valproate), and the clozapine had to be reduced rapidly to reduce risk of falls and functional impairment. This case emphasises the importance of a thorough medication review and detailed physical examination in patients with psychiatric disorders who develop falls when taking multiple and complex medications.

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Authors+Show Affiliations

Kenstavica Pinto J0000-0002-2521-8853Royal Free London NHS Foundation Trust, London, UK juliet.kenstavicapinto@nhs.net.
Rogers JP0000-0002-4671-5410Division of Psychiatry, University College London, London, UK. Department of Neuropsychiatry, National Hospital for Neurology and Neurosurgery, London, UK.
Berry AJ0000-0001-6231-541XDepartment of Neuropsychiatry, National Hospital for Neurology and Neurosurgery, London, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

42386215