- American Society for Clinical Pathology (ASCP) and ASCP Board of Certification medical and public health laboratory education financing study. [Journal Article]Am J Clin Pathol. 2026 Jul 06; 166(1).AJ
- CONCLUSIONS: Continued advocacy is essential to ensure that laboratory professionals remain included in federal and state scholarships, grants, and loan forgiveness programs. As policies governing educational funding evolve, it is increasingly important to engage stakeholders in championing financial support for laboratory professionals. Doing so will help reduce the burden of educational costs and strengthen pathways into laboratory careers, ultimately securing recruitment and retention.
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- The essentials-measurable residual disease in hematopoietic neoplasms: current testing landscape and future directions. [Review]Am J Clin Pathol. 2026 Jul 06; 166(1).AJ
- CONCLUSIONS: Consensus guidelines on MRD assessment in hematopoietic neoplasms continue to evolve. Further, emerging technologies and laboratory availability are important practical considerations for pathologists who are implementing MRD analysis. From this review, pathologists can gain an anecdotal perspective on the application and interpretation of advanced studies to assess the MRD status of patients with hematopoietic malignancies.
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- Clinicopathologic characterization of plasma cell neoplasms with IGH::CCND3. [Journal Article]Am J Clin Pathol. 2026 Jul 06; 166(1).AJ
- CONCLUSIONS: IGH::CCND3 PCNs frequently exhibit lymphoplasmacytoid features and CD20 expression, resembling the more common t(11;14) PCNs. Cyclin D3 IHC is an effective surrogate for the t(6;14) translocation in PCNs. We recommend using cyclin D3 IHC in the workup of PCNs with lymphoplasmacytoid morphology but negative cyclin D1 to appropriately trigger reflex FISH testing in positive cases and rescue them from the "partner-negative" category.
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- Communication patterns among surgical pathologists: a retrospective review of ideal strategies in a tertiary care setting. [Journal Article]Am J Clin Pathol. 2026 Jul 06; 166(1).AJ
- CONCLUSIONS: Pathologists adjust communication based on urgency, prioritizing rapid notification to qualified clinicians when needed. Flexible recipient selection may support timely clinical action and inform institutional communication policies.
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- Invasive urothelial carcinoma in association with surface low-grade papillary urothelial carcinoma: clinical and pathologic insights from a rare entity. [Journal Article]Am J Clin Pathol. 2026 Jun 04; 165(6).AJ
- CONCLUSIONS: These findings underscore the variable and unpredictable course of this disease phenotype, emphasizing its potential for aggressive evolution despite surface low-grade tumor histology. Vigilant surveillance and early consideration of definitive treatment may be a prudent strategy to mitigate progression risks in this rare subset of patients.
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- CEACAM1 expression by immunohistochemistry in B-cell lymphomas and plasma cell myeloma. [Journal Article]Am J Clin Pathol. 2026 Jun 04; 165(6).AJ
- CONCLUSIONS: CEACAM1 is frequently expressed in MCL and in subsets of other mature B-cell neoplasms and MM. These findings support further investigation of CEACAM1 as a biologically relevant marker and potential therapeutic target in selected lymphoid malignancies.
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- Comprehensive multicriteria life cycle assessment of biopsy processing in a surgical pathology department. [Journal Article]Am J Clin Pathol. 2026 Jun 04; 165(6).AJ
- CONCLUSIONS: These data allow us to better understand the environmental impacts of our activities and to propose more pertinent eco-design solutions.
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- Prognostic significance of Myb protein and its downstream target genes in lacrimal gland adenoid cystic carcinoma. [Journal Article]Am J Clin Pathol. 2026 Jun 04; 165(6).AJ
- CONCLUSIONS: Myb protein emerged as a prognostic indicator in the pathogenesis and clinical outcomes of patients with lacrimal gland ACC.
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- Mismatch repair protein "nonclassic expression loss" pattern in colorectal cancer: an important staining pattern that is not well understood. [Journal Article]Am J Clin Pathol. 2026 Jun 04; 165(6).AJ
- CONCLUSIONS: Microsatellite instability high status (30.77%) and Lynch syndrome (3.85%) can occur in patients with only nonclassic loss of MMR proteins (without the B pattern). It is necessary to deepen our understanding of nonclassical MMR expression patterns to avoid missing patients with microsatellite instability high status and Lynch syndrome.
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- Musculoskeletal pain in medical laboratory personnel: a cross-sectional study. [Journal Article]Am J Clin Pathol. 2026 Jun 04; 165(6).AJ
- CONCLUSIONS: A high prevalence of musculoskeletal pain was documented among medical laboratory personnel. Characterizing musculoskeletal pain in this population can help researchers understand the physiologic impacts of long-term exposure to laboratory work, as well as implement and evaluate prevention and risk reduction measures.
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- Histologic assessment of response to intraocular injection of amphotericin B in advanced rhino-sino-orbital mucormycosis. [Journal Article]Am J Clin Pathol. 2026 Jun 04; 165(6).AJ
- CONCLUSIONS: The considerably lower tissue destruction, fungal load, angioinvasion, and invasion of the optic nerve in orbital exenteration specimens following administration of IOAB indicates a promising role in the treatment of patients with RSOM and advanced involvement of the orbit.
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- Configuring large language models to deliver patient-facing explanations of pathology reports. [Journal Article]Am J Clin Pathol. 2026 Jun 04; 165(6).AJ
- CONCLUSIONS: Carefully configured LLM systems can generate patient-facing explanations of pathology reports comparable in quality to pathologist-written explanations. Prompting strategy, model size, and retrieval integration were associated with performance differences, underscoring the importance of system configuration in developing LLM-based tools to expand access to understandable pathology information.
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- MYC gene amplification drives protein overexpression and its clinical prognostic value in prostate cancer: a study of 152 Chinese cases. [Journal Article]Am J Clin Pathol. 2026 Jun 04; 165(6).AJ
- CONCLUSIONS: c-Myc activation, particularly MYC gene amplification, is a key driver and specific biomarker for an aggressive phenotype and poor prognosis in prostate adenocarcinoma. Combined detection of ERG, PTEN, and c-Myc status contributes to refining risk stratification systems. The lack of significant association between MYC amplification and ERG expression suggests they may represent distinct oncogenic pathways, warranting further validation in large prospective studies.
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- Flow cytometric quantitation of CD34+ progenitors in peripheral blood: an adjunct tool for diagnostic evaluation of pancytopenia. [Journal Article]Am J Clin Pathol. 2026 Jun 04; 165(6).AJ
- CONCLUSIONS: These findings support the potential clinical utility of peripheral blood CD34+ quantitation in the diagnostic workup of pediatric pancytopenia.
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- Mutation-specific NPM1 immunohistochemistry is a sensitive method for detecting residual disease in mid- and postinduction bone marrows: comparison of NPM1 immunohistochemistry, NPM1 real-time polymerase chain reaction, and flow cytometric studies. [Journal Article]Am J Clin Pathol. 2026 Jun 04; 165(6).AJ
- CONCLUSIONS: Mutation-specific NPM1 IHC is a valuable tool for a rapid assessment of residual morphologic and molecular disease in mid- and postinduction NPM1mut AML.
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