- Single-cohort next-generation sequencing analysis of 713 anaplastic thyroid carcinomas: unreported gene alterations and actionable targets. [Journal Article]Am J Clin Pathol. 2026 Aug 04; 166(2).AJ
- CONCLUSIONS: This largest single-cohort NGS data analysis identified 108 previously unreported genomic alterations in ATC, significantly expanding the understanding of the genomic landscape of this aggressive cancer. Moreover, these findings highlight a broad range of potentially actionable alterations and underscore the importance of identifying driver mutations and combination therapeutic strategies.
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- Measurement of hemolysis in packed red blood cell segments and units using H index. [Journal Article]Am J Clin Pathol. 2026 Aug 04; 166(2).AJ
- CONCLUSIONS: Our investigation revealed that pRBC segments had statistically significantly increased hemolysis compared with corresponding parent units. As a result, caution should be taken when using segments to assess hemolysis and other hematologic or metabolic testing.
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- Pathology goes viral: a qualitative review of #pathology content on TikTok. [Journal Article]Am J Clin Pathol. 2026 Aug 04; 166(2).AJ
- CONCLUSIONS: While the volume of pathology-specific content is currently limited, the high average engagement metrics-298 100 followers, 1.5 million views, and 67 884 likes per video-indicate substantial user interest. The higher-quality scores for educational and medical content suggest that pathology content creators are generally knowledgeable and accurately represent the field on TikTok, highlighting TikTok's potential as a valuable platform for disseminating reliable pathology-related information.
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- Acute myeloid leukemia with 4q12 rearrangements involving CHIC2: "pitfalls" in fluorescence in situ hybridization diagnosis of PDGFRA rearrangements. [Journal Article]Am J Clin Pathol. 2026 Aug 04; 166(2).AJ
- CONCLUSIONS: Molecular methods such as RNA-seq are effective for resolving cryptic 4q12 rearrangements in cases where FISH falsely suggests PDGFRA involvement. The distinct transcriptional profile of CHIC2-rearranged AML suggests dysregulated cytokine signaling and JAK-STAT activity in its pathogenesis.
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- Optical genome mapping refines diagnosis of high-grade myeloid neoplasms through detection of MECOM rearrangements cryptic to conventional karyotype. [Journal Article]Am J Clin Pathol. 2026 Aug 04; 166(2).AJ
- CONCLUSIONS: Optical genome mapping doubled the detection rate and improved the structural resolution of MECOM-r by identifying rearrangements incompletely resolved or missed by conventional cytogenetics. Implementation of OGM showed that MECOM-r can be cryptic and frequently overlooked, highlighting the value of high-resolution testing in HGMNs.
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- Structured workflow for send-out test review: operational performance and utilization patterns. [Journal Article]Am J Clin Pathol. 2026 Jul 06; 166(1).AJ
- CONCLUSIONS: Implementation of a structured workflow for send-out test review enabled standardized documentation, rapid turnaround, and improved visibility into utilization patterns. This approach provides a scalable framework for enhancing laboratory oversight and supporting targeted test utilization interventions.
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- Unique characteristics of Lynch syndrome-associated mismatch repair-deficient colorectal intramucosal carcinoma. [Journal Article]Am J Clin Pathol. 2026 Jul 06; 166(1).AJ
- CONCLUSIONS: These findings suggest that LS-associated MMR-D IMCs have distinct clinicopathologic and immunophenotypic profiles compared with MMR-P and sporadic MMR-D IMCs, emphasizing the need for unique diagnostic and management strategies for these patients.
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- Deep learning-based detection of acid-fast bacilli in microscopy images: a systematic review. [Systematic Review]Am J Clin Pathol. 2026 Jul 06; 166(1).AJ
- CONCLUSIONS: Deep learning-based AFB detection systems demonstrate high accuracy and strong potential to enhance tuberculosis microscopy. Heterogeneity in study design and limited external validation, however, highlight the need for standardized evaluation and multicenter clinical studies before widespread implementation.
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- Enhancing efficiency and improving turnaround time: real-world impact of the Genius Digital Diagnostics System implementation. [Journal Article]Am J Clin Pathol. 2026 Jul 06; 166(1).AJ
- CONCLUSIONS: Implementation of Genius Dx substantially increased reviewer efficiency and reduced turnaround times without compromising diagnostic performance. The increased detection of ASC-US+ findings observed in this study are in line with results from the Genius Dx clinical trial and other published literature.
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- Standardized protocols for reflexing to a multigene panel for patients with non-small cell lung cancer: prevalence and perceived barriers to comprehensive, pathologist-ordered biomarker reflex testing. [Journal Article]Am J Clin Pathol. 2026 Jul 06; 166(1).AJ
- CONCLUSIONS: Locally standardized protocols incorporating reflex multigene panel testing have been reported and are associated with high rates of CBT. Institutional and operational barriers delay the availability of results and limit the impact of these protocols on first‑line treatment decisions. Clarifying CMS guidance on pathologists as valid ordering physicians for broad biomarker panels, strengthening coordination with multidisciplinary teams, addressing workflow constraints, and educating the laboratories and payers on pathologists having ordering authority may enhance the effectiveness and adoption of reflex biomarker testing models.
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- Additive diagnostic value of liquid‑based preparation and conventional smears in Bethesda I thyroid nodules. [Journal Article]Am J Clin Pathol. 2026 Jul 06; 166(1).AJ
- CONCLUSIONS: We did not demonstrate an additive effect for the LBP method. However, it may still be preferable in nodules with abnormal TSH levels, heterogeneous cystic features, or macrocalcifications. The prospective findings indicate a clinical advantage for CS analysis. Accordingly, we recommend performing aspiration for both techniques, using CS only if a nondiagnostic result is obtained for LBP.
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- American Society for Clinical Pathology (ASCP) and ASCP Board of Certification medical and public health laboratory education financing study. [Journal Article]Am J Clin Pathol. 2026 Jul 06; 166(1).AJ
- CONCLUSIONS: Continued advocacy is essential to ensure that laboratory professionals remain included in federal and state scholarships, grants, and loan forgiveness programs. As policies governing educational funding evolve, it is increasingly important to engage stakeholders in championing financial support for laboratory professionals. Doing so will help reduce the burden of educational costs and strengthen pathways into laboratory careers, ultimately securing recruitment and retention.
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- The essentials-measurable residual disease in hematopoietic neoplasms: current testing landscape and future directions. [Review]Am J Clin Pathol. 2026 Jul 06; 166(1).AJ
- CONCLUSIONS: Consensus guidelines on MRD assessment in hematopoietic neoplasms continue to evolve. Further, emerging technologies and laboratory availability are important practical considerations for pathologists who are implementing MRD analysis. From this review, pathologists can gain an anecdotal perspective on the application and interpretation of advanced studies to assess the MRD status of patients with hematopoietic malignancies.
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- Clinicopathologic characterization of plasma cell neoplasms with IGH::CCND3. [Journal Article]Am J Clin Pathol. 2026 Jul 06; 166(1).AJ
- CONCLUSIONS: IGH::CCND3 PCNs frequently exhibit lymphoplasmacytoid features and CD20 expression, resembling the more common t(11;14) PCNs. Cyclin D3 IHC is an effective surrogate for the t(6;14) translocation in PCNs. We recommend using cyclin D3 IHC in the workup of PCNs with lymphoplasmacytoid morphology but negative cyclin D1 to appropriately trigger reflex FISH testing in positive cases and rescue them from the "partner-negative" category.
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- Communication patterns among surgical pathologists: a retrospective review of ideal strategies in a tertiary care setting. [Journal Article]Am J Clin Pathol. 2026 Jul 06; 166(1).AJ
- CONCLUSIONS: Pathologists adjust communication based on urgency, prioritizing rapid notification to qualified clinicians when needed. Flexible recipient selection may support timely clinical action and inform institutional communication policies.
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