- Validation of a modified plasma-based cell block technique using activated partial thromboplastin time-ellagic acid reagent in body fluid and fine needle aspiration samples in cytology. [Journal Article]Am J Clin Pathol. 2026 May 05; 165(5).AJ
- CONCLUSIONS: Modified plasma-based cell block testing improves diagnostic yield and preserves morphology. Compatible with a broad spectrum of ancillary testing, chiefly immunohistochemistry and commonly used molecular tests, it is a feasible and cost-effective alternative.
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- Primary Paget-like intraepithelial glandular lesion of the bronchus: report of a first case. [Case Reports]Am J Clin Pathol. 2026 May 05; 165(5).AJ
- CONCLUSIONS: We report the first case of primary Paget-like intraepithelial glandular neoplasia originating in the bronchial epithelium. While the clinical significance of this unusual finding is unknown, it challenges the existing hypotheses concerning the cellular origin of extramammary Paget disease, which include Toker cells, pluripotent keratinocyte stem cells, and apocrine gland ducts, none of which are native to the bronchial epithelium.
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- Re-evaluating archival specimens as a pathologic diagnostic resource for neuronal intranuclear inclusion disease. [Journal Article]Am J Clin Pathol. 2026 May 05; 165(5).AJ
- CONCLUSIONS: Routine archival surgical specimens may provide a readily available pathologic resource that avoids additional invasive biopsy for confirming NIID. Their consistent cellular distribution pattern may also facilitate recognition of diagnostic inclusions in routine pathology practice.
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- Low-value flow cytometry testing: from identification to prevention. [Journal Article]Am J Clin Pathol. 2026 May 05; 165(5).AJ
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- Hilar fat invasion is a poorly defined and inconsistently interpreted lung carcinoma staging parameter. [Journal Article]Am J Clin Pathol. 2026 May 05; 165(5).AJ
- CONCLUSIONS: There is a lack of consensus among pathologists as to what constitutes hilar fat invasion, resulting in considerable interobserver variability in pT categorization. Making hilar fat invasion a standard pT designation could improve awareness, and defining the anatomic boundaries of hilar fat could result in greater consistency in assigning a pT category to tumors that extend into fat outside the lung.
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- Radiation injury to the lung caused by yttrium-90 resin microspheres (SIR-Spheres) diagnosed by transbronchial lung biopsy. [Case Reports]Am J Clin Pathol. 2026 May 05; 165(5).AJ
- CONCLUSIONS: This is the first report of a case in which transbronchial lung biopsy led to diagnosis of 90Y-related radiation lung injury in a patient in whom this diagnosis was not previously suspected clinically or radiologically. We recommend adding 90Y to the list of etiologies of acute lung injury with eosinophils. Pathologists should familiarize themselves with the histologic appearance of 90Y microspheres because identification of these structures in the lung can be diagnostic.
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- Intravenous immunoglobulin administration may obscure the detection of small monoclonal proteins in patients with multiple myeloma. [Case Reports]Am J Clin Pathol. 2026 May 05; 165(5).AJ
- CONCLUSIONS: Administration of IVIG may lead to false-negative SPE/IFE interpretations by masking small monoclonal proteins. Because the detection of M-proteins is critical for distinguishing between complete response and very good partial response or identifying disease relapse, laboratory professionals must be aware of a patient's IVIG treatment status when interpreting electrophoresis results.
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- Acute leukemias with expression of CD56. [Review]Am J Clin Pathol. 2026 May 05; 165(5).AJ
- CONCLUSIONS: Acute leukemias with CD56 expression represent a diagnostically challenging and biologically diverse group of neoplasms. While CD56 lacks lineage specificity, its detection by flow cytometry provides valuable information for differential diagnosis, risk stratification, and, in some settings, minimal residual disease assessment. Accurate classification requires careful integration of immunophenotypic, morphologic, and genetic data. As therapeutic strategies become increasingly risk-adapted and targeted, precise recognition of CD56-positive blastoid neoplasms is essential to optimize patient management and outcomes.
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- Defining baseline high-sensitivity cardiac troponin levels in healthy collegiate athletes. [Journal Article]Am J Clin Pathol. 2026 May 05; 165(5).AJ
- CONCLUSIONS: These findings support athlete-focused interpretation of hs-cTnI incorporating sex-specific thresholds, standardized postexercise sampling, and sport context. Such tailored approaches may reduce false-positive results and unnecessary evaluations while preserving diagnostic accuracy for true myocardial pathology.
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- Chronic myelomonocytic leukemia without increased classical monocyte subsets exhibits a distinct genetic profile, including frequent CBL mutations. [Journal Article]Am J Clin Pathol. 2026 May 05; 165(5).AJ
- CONCLUSIONS: Chronic myelomonocytic leukemia without increased CM subsets is associated with a distinct genetic profile characterized by enrichment of CBL mutations. Mechanistically, we hypothesize that CBL mutations promote proinflammatory signaling that contributes to normalization of CM partitioning.
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- Analysis of safety reporting in the clinical laboratory of a large academic medical center: frequency, type, and classification by phase of testing. [Journal Article]Am J Clin Pathol. 2026 May 05; 165(5).AJ
- CONCLUSIONS: A large number of safety reports are generated in our large academic medical center. Most involve the preanalytical phase but do not result in direct patient harm. Despite improvements in information technology to improve the reliability of the preanalytical phase of testing, most reports reflect incidents outside the clinical laboratory.
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- Salivary and serum microRNAs as noninvasive biomarkers for distinguishing prostate cancer from benign prostatic hyperplasia. [Journal Article]Am J Clin Pathol. 2026 May 05; 165(5).AJ
- CONCLUSIONS: Selected miRNAs, particularly miR-182 and miR-96, reliably differentiate PCa from BPH in both serum and saliva. Integration with PSA further enhances diagnostic performance, and salivary profiling represents a practical, noninvasive approach for early molecular screening.
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- Diagnostic sensitivity and specificity of INSM1 in pheochromocytomas versus adrenal cortical lesions. [Journal Article]Am J Clin Pathol. 2026 May 05; 165(5).AJ
- CONCLUSIONS: When attempting to distinguish pheochromocytomas from adrenal cortical lesions, INSM1 and GATA3 can be effective immunohistochemical tools with excellent sensitivity and specificity. However, while they may be helpful adjuncts in diagnostically challenging cases, chromogranin remains the gold-standard marker with even higher sensitivity and specificity.
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