(American Journal of Obstetrics Gynecology[TA])
44,229 results
  • IVF-Conceived Offspring Exhibit Altered LINE-1 Retrotransposition Dynamics Associated with Long-Term Disease Risks. [Journal Article]
    Am J Obstet Gynecol. 2026 May 21. [Online ahead of print]Li J, Huang J, … Li YAJ
  • CONCLUSIONS: These findings provide preliminary evidence that IVF conception is associated with increased L1 content and altered genomic distribution of L1 elements. The proximity of these differential L1 sites to disease-associated genes suggests a plausible genomic mechanism linking IVF-associated embryonic stress to elevated disease risk. This work provides valuable molecular insights that may inform the ongoing discussion about assisted reproductive technology safety, and suggests that continued attention to genomic integrity in IVF-conceived individuals would be beneficial.
  • In a Rodent Model, Low-Dose Maternal Magnesium Sulfate Achieves Comparable Neuroinflammatory Attenuation to Higher Dose. [Journal Article]
    Am J Obstet Gynecol. 2026 May 21. [Online ahead of print]Ginsberg Y, Bang S, … Beloosesky RAJ
  • CONCLUSIONS: In this experimental model, low-dose maternal Mg was as effective as a higher-dose regimen in attenuating fetal brain and placental pro-inflammatory cytokine expression following LPS-induced maternal inflammation. These findings suggest that a reduced Mg exposure, equivalent to a 4g loading dose in clinical practice, may be sufficient for fetal neuroprotection, and support the need for prospective clinical studies comparing reduced-duration Mg protocols.