(American Journal of Ophthalmology[TA])
28,876 results
  • Morphologic Staging of Photoreceptor Damage as a Predictor of Visual Recovery After PDT in Chronic Central Serous Chorioretinopathy. [Journal Article]
    Am J Ophthalmol. 2026 May 23. [Online ahead of print]Berni A, Scalabrin G, … Borrelli EAJ
  • CONCLUSIONS: In chronic CSC, symptom duration determines the likelihood of anatomical recovery after PDT, whereas photoreceptor integrity is the key determinant of visual acuity recovery. The proposed six-stage OCT classification provides a reproducible structural biomarker that captures cumulative photoreceptor injury and robustly predicts visual prognosis, offering a clinically useful framework for treatment counseling, stratification in CSC trials, and future automated imaging analysis.
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  • Cost Analysis of an Outpatient MRI Pathway for Optic Disc Edema: A Time-Driven Activity-Based Costing Approach. [Journal Article]
    Am J Ophthalmol. 2026 May 22. [Online ahead of print]Guillot FH, Davis J, … Henderson ADAJ
  • CONCLUSIONS: An outpatient STAT neuroimaging pathway is a cost- and time-saving alternative to the ED for expedited neuroimaging in select patients presenting with optic disc edema. The novel use of TDABC methodology in this setting allowed for an unbiased assessment of healthcare costs, independent of local reimbursement structures or payor variability. Additionally, a detailed process map of the imaging workflow facilitated identification of inefficiencies. Together, these methods provide a reliable framework to optimize care pathways, substantially reduce healthcare costs, and alleviate burden on EDs.
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  • Centripetal retinal degeneration follows an exponential decay and may be reversed following gene therapy. [Journal Article]
    Am J Ophthalmol. 2026 May 22. [Online ahead of print]Elsayed MEAA, Josan AS, … MacLaren REAJ
  • CONCLUSIONS: Our findings suggest that centripetal retinal degeneration in rod-cone dystrophies follows an exponential decay and that gene therapy may reverse both structural and functional deficits. PRéCIS: : Centripetal retinal degeneration in inherited retinal degenerations appears to follow an exponential decay function and may be reversed due to anatomical regeneration of the retina following RPGR gene therapy in a landmark clinical trial.
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  • Ocular Hypertension Treatment Study: Effect of time after incident glaucoma on OCT optic nerve head and macula measurements. [Journal Article]
    Am J Ophthalmol. 2026 May 21. [Online ahead of print]Walker E, Bowd C, … Zangwill LMAJ
  • CONCLUSIONS: In the OHTS, the ocular hypertensive eyes that developed POAG had significantly thinner RNFL and GCIPL measurements compared with the ocular hypertensive eyes that did not develop glaucoma. In addition, longer duration of POAG was associated with thinner RNFL/GCIPL independent of POAG treatment status and IOP level. These results characterize the magnitude of RNFL and GCIPL thinning associated with increasing POAG duration and reinforce the role of OCT as a key tool for monitoring glaucomatous structural change in eyes with OH.
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  • The Neovascular Ocular Hypertension Spectrum: A Novel Classification of Neovascular Glaucoma. [Journal Article]
    Am J Ophthalmol. 2026 May 21. [Online ahead of print]Swaminathan SS, Qiu MAJ
  • CONCLUSIONS: The NVOH spectrum offers a modernized, anatomically grounded alternative to the ambiguous term "neovascular glaucoma." By prioritizing angle status and disease activity over optic nerve assessment, which is often unreliable in eyes with advanced retinal disease, this classification supports more precise diagnosis, tailored treatment selection, and improved interdisciplinary communication. Prospective studies are needed to validate this nomenclature, refine stage-specific treatment algorithms, and assess its impact on clinical outcomes.
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