- Inflammatory iris nodule in acute anterior uveitis: AS-OCT Follow-up. [Journal Article]Am J Ophthalmol. 2026 Aug 06. [Online ahead of print]AJ
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- No-History IOL Power Calculation After Myopic Laser Vision Correction: A Multicenter Retrospective Database Study of 14 Formulas With and Without Posterior Corneal Curvature. [Journal Article]Am J Ophthalmol. 2026 Aug 05. [Online ahead of print]AJ
- CONCLUSIONS: In eyes with satisfactory postoperative visual acuity, modern formulas outperform early-generation formulas, and PCC-based versions are preferable. With AL <23.5 or K >43 D (22% of these eyes), online modern formulas-particularly K6 and EVO 2.0-provided the greatest accuracy gain vs. Barrett True K. In typical post-M-LVC eyes, such gains are clinically negligible. When full biometry is unavailable, Shammas-Cooke is a reasonable alternative.
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- Neighborhood Socioeconomic Deprivation and Adherence to Diabetic Retinopathy Screening Guidelines. [Journal Article]Am J Ophthalmol. 2026 Aug 05. [Online ahead of print]AJ
- CONCLUSIONS: In this nationwide cohort, there was a significantly increased risk of nonadherence to annual diabetic retinopathy screening with increasing ADI.
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- Pseudohypopyon following Triamcinolone and Silicone Oil Tamponade in a Phakic Eye. [Journal Article]Am J Ophthalmol. 2026 Aug 05. [Online ahead of print]AJ
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- Factors associated with delays in the diagnosis of childhood onset uveitis: findings from a nation-wide cohort study. [Journal Article]Am J Ophthalmol. 2026 Aug 04. [Online ahead of print]AJ
- CONCLUSIONS: Delays in diagnosis occur in childhood uveitis of symptomatic onset, with symptoms being prevalent in disease. Improved awareness of this blinding disorder among primary-care practitioners, standardized referral pathways for childhood eye complaints, and equitable access to eye services are needed to prevent childhood onset, life-long visual disability.
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- In Vivo Microscopic Assessment of Ocular Surface Changes Induced by Antiglaucoma Medications. [Journal Article]Am J Ophthalmol. 2026 Aug 04. [Online ahead of print]AJ
- CONCLUSIONS: Chronic use of topical antiglaucoma medications greatly contributes to the severity of OSD amongst glaucoma patients in a dose-dependent manner. Patients treated with antiglaucoma medications not only have severe OSD symptoms but also microstructural anatomic changes to the central cornea, characterized by inflammation and corneal nerve attenuation. Clinicians should recognize the unintended effects of antiglaucoma medications on the ocular surface.
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- Optical coherence tomography-guided focal navigated laser photocoagulation in central serous chorioretinopathy: a non-inferiority study. [Journal Article]Am J Ophthalmol. 2026 Aug 04. [Online ahead of print]AJ
- CONCLUSIONS: Focal navigated laser photocoagulation planned solely based on en face OCT demonstrated non-inferior safety and efficacy compared with conventional FA-guided treatment for non-resolving CSCR with focal leakage.
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- Glaucoma and Neurodegenerative Disease Risk: A 10-Year Assessment of Real-World Global Data. [Journal Article]Am J Ophthalmol. 2026 Aug 03. [Online ahead of print]AJ
- CONCLUSIONS: Glaucoma is observationally associated with subsequent neurodegenerative diagnoses, with statistical trajectories varying by onset age and clinical subtype. These findings indicate population-level correlations rather than causal mechanistic linkages.
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- Refining How We Diagnose and Classify Limbal Stem Cell deficiency. [Review]Am J Ophthalmol. 2026 Aug 03. [Online ahead of print]AJ
- CONCLUSIONS: LSCD diagnosis and classification have advanced beyond the simple fluorescein staining test for the detection of abnormal epithelial cells on the corneal surface. A comprehensive assessment of the LSC function and the ocular surface environment by integrating multimodal imaging and molecular testing enables precise staging of LSC function and identification of factors that influence LSCD reversibility. Adoption of a standardized multimodal diagnostic framework will improve diagnostic accuracy, guide the management of the disease, facilitate comparisons across clinical studies, and support the development and evaluation of emerging cell-based and cell-free regenerative therapies for LSCD.
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- Central Retinal Vessel Trunk Dragging in Highly Myopic Eyes. [Journal Article]Am J Ophthalmol. 2026 Aug 03. [Online ahead of print]AJ
- CONCLUSIONS: CRVT-dragging as a common feature in highly myopic eyes may etiologically be explained by the myopic axial elongation-related increase in the fovea-disc distance. Influencing the three-dimensional appearance of the optic nerve head, CRVT dragging may be of importance for the morphological diagnosis of optic neuropathies in highly myopic eyes.
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- Comment on: Accuracy of toric intraocular lens realignment calculators: A vector-based bivariate comparison of current calculation methods. [Letter]Am J Ophthalmol. 2026 Aug 01. [Online ahead of print]AJ
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- Reply to Comment on "Accuracy of toric intraocular lens realignment calculators: A vector-based bivariate comparison of current calculation methods". [Letter]Am J Ophthalmol. 2026 Aug 01. [Online ahead of print]AJ
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- Efficacy, Safety, and Durability of Gene Therapy for Inherited Retinal Diseases in the Paediatric Population: A Scoping Review. [Review]Am J Ophthalmol. 2026 Jul 31. [Online ahead of print]AJ
- CONCLUSIONS: Paediatric benefit from IRD gene therapy depends on genotype, residual retinal structure, therapeutic platform, dose, surgical strategy, and outcome measure. The major evidence gaps are long-term paediatric durability and inconsistent age-stratified reporting. Future paediatric-inclusive trials should pre-specify subgroup analyses, embed prospective long-term follow-up, use developmentally appropriate endpoints, and report individual-level data sufficient to support paediatric inference.
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- Stem Cell Therapy for Inherited Retinal Disorders: Rebuilding the Retina. [Review]Am J Ophthalmol. 2026 Jul 30. [Online ahead of print]AJ
- Inherited retinal disorders (IRDs) are a group of ophthalmic conditions that are characterized by progressive degeneration of photoreceptors and/or retinal pigment epithelium (RPE), leading to irreversible vision loss. IRDs are a promising target for stem cell therapies, which have largely aimed to restore vision by either replacement of degenerated photoreceptors or retinal pigment epithelial ce…
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- Challenges to the Access and Utilization of Corneal Cross-Linking in Keratoconus Patients in the United States. [Journal Article]Am J Ophthalmol. 2026 Jul 29. [Online ahead of print]AJ
- CONCLUSIONS: With the approval of Epioxa™ and planned phasing out of Photrexa®, we underscore the risk of exacerbating disparities in access to CXL and propose the formation of an interdisciplinary taskforce aimed at an access framework for CXL therapy for all patients. We believe the first step is to pause the phasing out of Photrexa® until (1) there is a formalized plan in place to combat the issues of CXL access as detailed here and (2) long-term efficacy of Epioxa™ can be sufficiently demonstrated.
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