- Effect of Pre-operative Intravenous Crystalloid Bolus on Post-Induction Blood Pressure - a randomized blinded intervention trial. [Journal Article]Anesthesiology. 2026 Aug 07. [Online ahead of print]A
- CONCLUSIONS: In this blinded randomized clinical trial, administering a crystalloid fluid bolus within 60 minutes before surgery did not significantly reduce the time-weighted average of a mean arterial pressure less than 65 mmHg compared to standard care in patients with cardiovascular risk factors undergoing major non-cardiac surgery. Our study suggests that administering crystalloids before surgery does not prevent post-induction hypotension.
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- Fragility Index of Randomized Clinical Trials in Perioperative Anesthesia: A Methodological Survey of Guideline-Supporting Evidence. [Journal Article]Anesthesiology. 2026 Aug 07. [Online ahead of print]A
- CONCLUSIONS: Randomized superiority trials underpinning contemporary perioperative guideline recommendations are generally small and demonstrate modest Fragility Index values, indicating that statistical conclusions often depend on relatively few outcome events. Fragility metrics should complement, rather than replace, established measures of trial quality and evidence certainty when interpreting perioperative evidence.
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- Perioperative Hypoperfusion Stroke. [Journal Article]Anesthesiology. 2026 Aug 04. [Online ahead of print]A
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- Dose-Response Effects of Anterior Chest Wall Loading on Lung Mechanics, Regional Ventilation, and Hemodynamics in Acute Respiratory Distress Syndrome: A Prospective Physiological Study. [Journal Article]Anesthesiology. 2026 Aug 04. [Online ahead of print]A
- CONCLUSIONS: In moderate-to-severe ARDS, ACWL induced dose-dependent changes in pleural pressure and respiratory mechanics. By increasing non-dependent pleural pressure, it relieved non-dependent overdistension and lowered transpulmonary ΔP, but simultaneously caused dependent derecruitment and, by increasing central venous pressure, hemodynamic compromise. These findings support ACWL as a physiological probe of lung-chest wall interactions rather than a therapeutic intervention.
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- HIF1A-dependent induction of alveolar miR-147b dampens SARS-CoV-2-associated ARDS via direct targeting of viral RNA. [Journal Article]Anesthesiology. 2026 Aug 04. [Online ahead of print]A
- CONCLUSIONS: Alveolar epithelial cell-derived miR-147b serves as an endogenous lung protective miRNA against SARS-CoV-2-associated ARDS by directly targeting virus-encoded RNA, revealing a previously unrecognized antiviral and lung-protective mechanism.
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- The Adolescent Surgery Experience (ASE) prospective cohort study: Postoperative pain trajectory, opioid use and satisfaction. [Journal Article]Anesthesiology. 2026 Aug 04. [Online ahead of print]A
- CONCLUSIONS: After major surgery, a high proportion of adolescents endorsed persistent pain in Month 3 despite relative recovery satisfaction. In addition, an unanticipated number used opioids after resolution of severe pain for which opioids may be indicated.
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- Development and external validation of a multimodal artificial intelligence mortality prediction model of critically ill patients using multicenter data. [Journal Article]Anesthesiology. 2026 Aug 04. [Online ahead of print]A
- CONCLUSIONS: Our findings highlight the importance of incorporating multiple sources of patient information for mortality prediction and the importance of external validation.
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- Effects of Intraoperative Nociception Monitoring during Adolescent Idiopathic Scoliosis Correction. [Journal Article]Anesthesiology. 2026 Aug 03. [Online ahead of print]A
- CONCLUSIONS: The administration of remifentanil guided by intraoperative nociception monitoring during AIS did not result in a reduction of postoperative opioid consumption.Registration on ClinicalTrials.gov: NCT04047225.
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- Assessing the Reliability of Telehealth Geriatric Screening in Older Adults Undergoing Surgery. [Journal Article]Anesthesiology. 2026 Jul 30. [Online ahead of print]A
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- Born: The Untold History of Childbirth. [Journal Article]Anesthesiology. 2026 Jul 29. [Online ahead of print]A
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- Orchestrating Communication in the Expanding Anesthesia Enterprise. [Journal Article]Anesthesiology. 2026 Jul 29. [Online ahead of print]A
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- Unexpected Failure of Bronchial Blocker Placement Due to an Undiagnosed Tracheal Bronchus. [Journal Article]Anesthesiology. 2026 Jul 29. [Online ahead of print]A
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- Ultrasound Findings of Chronic Inflammatory Demyelinating Polyneuropathy of the Sciatic Nerve. [Journal Article]Anesthesiology. 2026 Jul 29. [Online ahead of print]A
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- Measures of Quality of Recovery and Discharge-readiness Tools in the Pediatric Postanesthesia Care Unit. [Journal Article]Anesthesiology. 2026 Jul 28. [Online ahead of print]A
- The postanesthesia care unit is a critical phase of recovery, yet routine assessment often focuses on discharge readiness rather than the child's recovery experience. This study reviewed measures used in pediatric postanesthesia care unit pathways to assess discharge readiness and early recovery quality and synthesized how they capture domains that matter to children, families, and clinicians. Th…
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- Comparison of anesthetic effects of different sedative drugs combined with remifentanil for general anesthesia in bronchoscopy: a randomized controlled trial. [Randomized Controlled Trial]
- CONCLUSIONS: Etomidate demonstrates superior hemodynamic stability but carries a higher risk of PONV. In contrast, ciprofol and remimazolam offer better postoperative comfort. For patients at high risk of hemodynamic instability, etomidate may be preferred with enhanced PONV prophylaxis; for those at high risk of PONV or desiring rapid and comfortable recovery, ciprofol or remimazolam are more suitable options.
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