- Defining and validating a high specificity MRI cut-off for the radiographic part of the modified New York criteria in patients with axial spondyloarthritis. [Journal Article]Arthritis Res Ther. 2026 Jul 17. [Online ahead of print]AR
- CONCLUSIONS: A composite MRI-score based on assessing erosion, backfill and ankylosis for five predefined semicoronal SIJ slices (CSDS5) was the optimal high specificity MRI cut-off to rad-mNYc positivity, being potentially usable in both research and clinical settings, with different thresholds depending on whether sensitivity or specificity is prioritized.
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- Evaluating clinical heterogeneity in relapsing polychondritis through unsupervised cluster analysis. [Journal Article]Arthritis Res Ther. 2026 Jul 11. [Online ahead of print]AR
- CONCLUSIONS: This study confirms that relapsing polychondritis is not a single-dimensional disease, but a clinical syndrome with significant heterogeneity. Random forest analysis further identifies that systemic inflammation markers (CRP, CAR, ESR) and sensory organ involvement (hearing impairment and inner ear dysfunction) as the most critical driving factors for distinguishing these subtypes.
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- Real-world treatment patterns and determinants of therapy in systemic sclerosis: findings from the German Network for SSc cohort. [Journal Article]
- CONCLUSIONS: SSc treatment has evolved over the past 25 years, with prescribing patterns increasingly reflecting evidence and guideline recommendations. However, differences between specialties and care settings highlight the need for broader implementation of multidisciplinary, guideline-based care.
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- DAS28-ESR may underestimate disease activity in rheumatoid arthritis patients with nonalcoholic fatty liver disease: a retrospective cohort study. [Journal Article]Arthritis Res Ther. 2026 Jul 08. [Online ahead of print]AR
- CONCLUSIONS: Among patients with RA classified as having NAFLD, DAS28-ESR may underestimate disease activity compared with CRP-based or clinical indices. In these patients, DAS28-CRP, CDAI, and SDAI may provide complementary information.
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- Differential gene expression of retrotransposons (LTR and non-LTR) in peripheral blood leukocytes of people with gout. [Journal Article]Arthritis Res Ther. 2026 Jul 06. [Online ahead of print]AR
- CONCLUSIONS: This study reveals a distinct and dynamic retrotransposon signature in gout, with potential implications priming, immune cell behavior, and gene regulation.
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- Alterations in systemic and skeletal muscle myostatin regulation are most prominent at disease onset and associate with muscle-related outcomes in idiopathic inflammatory myopathies. [Journal Article]Arthritis Res Ther. 2026 Jul 02. [Online ahead of print]AR
- CONCLUSIONS: Early IIM is characterized by dissociation between reduced circulating MSTN and activation of MSTN signalling in skeletal muscle, which diminishes with treatment and disease chronicity. Circulating FSTL3 is associated with systemic inflammation, disease activity and patient-reported outcomes, with pronounced associations in female patients. These findings highlight stage- and sex-dependent alterations of the MSTN regulatory network in IIM.
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- Plasma proteome differences between giant cell arteritis and polymyalgia rheumatica: a pilot study. [Journal Article]Arthritis Res Ther. 2026 Jul 01. [Online ahead of print]AR
- CONCLUSIONS: Active PMR and active GCA patients share an unexpectedly small plasma proteome signature related to immune activation (8.9%: 13 proteins). Instead, active PMR is characterized by distinct erythrocyte and muscle contraction proteome changes, whereas active GCA appears driven by mitochondrial and clotting cascade alterations. Prospective, longitudinal validation studies of the described proteomic signatures might support the clinical classification of both diseases.
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- Elucidating the mechanism of taurine in alleviating osteoarthritis progression based on bioinformatics, machine learning algorithm, and experimental validation. [Journal Article]Arthritis Res Ther. 2026 Jun 30. [Online ahead of print]AR
- CONCLUSIONS: Taurine exerted significant chondroprotective effects, at least in part, by directly targeting CTH to suppress chondrocyte ferroptosis, thereby ameliorating OA progression.
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- Discovery of biomarkers for primary Sj ögren's syndrome based on multi-omics data, construction of diagnostic models, and clinical correlation analysis. [Journal Article]Arthritis Res Ther. 2026 Jun 29. [Online ahead of print]AR
- CONCLUSIONS: This study systematically defines specific metabolic features of pSS, establishes a validated diagnostic model for SNSS, and confirms the close association between metabolic disturbances and clinical heterogeneity. The findings provide novel metabolic biomarkers and insights for the precise diagnosis and management of pSS.
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- Identification of distinct subgroups in Chinese patients with Behçet's syndrome via cluster analysis of immune cells and clinical features. [Journal Article]
- CONCLUSIONS: Unsupervised clustering of BS patients revealed four distinct subtypes with significant clinical and immunological heterogeneity, which may provide a foundation for mechanistic studies and personalized treatment.
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- Artemisinin increases susceptibility to ferroptosis of fibroblast-like synoviocytes in rheumatoid arthritis. [Journal Article]Arthritis Res Ther. 2026 Jun 26. [Online ahead of print]AR
- CONCLUSIONS: Artemisinin can increase the sensitivity of FLSs to ferroptosis and inhibit the proliferation of synovial cells in rheumatoid arthritis. The P53-SLC7A11 pathway play the important role in this process.
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- Tripartite motif containing 21 autoimmunity primes CD8[+] cell-mediated lung inflammation: an in vivo model of interstitial lung disease pathogenesis. [Journal Article]Arthritis Res Ther. 2026 Jun 26. [Online ahead of print]AR
- CONCLUSIONS: These findings support a pathogenic role for anti-Ro52/TRIM21 autoimmunity in CTD-associated ILD. Our in vivo model reveals a lung-predominant inflammatory response associated with CD8[+] cell that is amplified by viral mimicry and accompanied by CCL6 signaling, offering mechanistic insight and potential therapeutic targets in anti-Ro52 positive ILD.
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- Safety, tolerability, pharmacokinetics, and pharmacodynamics of ABP-671 in healthy participants and patients with hyperuricemia and gout: a proof-of-concept study. [Journal Article]Arthritis Res Ther. 2026 Jun 22. [Online ahead of print]AR
- CONCLUSIONS: ABP-671 had an acceptable safety profile in Chinese healthy participants and patients with hyperuricemia and gout. ABP-671 reduced serum urate levels in a dose-dependent manner.
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- Targeting inflammatory and angiogenic responses by small-molecule kinase inhibitors in a 3D macrophage-containing spheroid model of rheumatoid arthritis synovial tissue. [Journal Article]Arthritis Res Ther. 2026 Jun 23. [Online ahead of print]AR
- CONCLUSIONS: This human 3D multicellular in vitro spheroid model of synovial inflammation recapitulates key RA pathological processes and provides a robust platform for mechanistic studies and therapeutic evaluation.
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