- Tophus measurement as an outcome measure in gout: an updated systematic literature review. [Review]Semin Arthritis Rheum. 2026 May 15; 79:153000. [Online ahead of print]SA
- CONCLUSIONS: There is evidence to support the feasibility, truth and discrimination of Vernier callipers. US, DECT and the TIQ-20 fulfil many aspects of the Filter but have not yet demonstrated a difference between arms of a RCT. Overall, Vernier callipers have evidence for each pillar of the Filter and are a strong candidate for endorsement as an instrument of tophus measurement.
- Publisher Full Text (DOI)
- MRI-defined tissue damage as predictors of the incidence and progression of knee osteoarthritis: A systematic review. [Review]Semin Arthritis Rheum. 2026 May 13; 79:152999. [Online ahead of print]SA
- CONCLUSIONS: Several MRI-detected joint tissue pathologies longitudinally associated with structural progression and clinically relevant outcomes, such as total knee arthroplasty, allowing patient stratification for disease-modifying osteoarthritis drug (DMOAD) trials. These associations may be further strengthened using compositional and multi-featured MRI models as well as AI-based feature extraction.
- Publisher Full Text (DOI)
- Trabecular bone score in glucocorticoid-induced osteoporosis: A systematic review and meta-analysis. [Review]Semin Arthritis Rheum. 2026 May 15; 79:153001. [Online ahead of print]SA
- CONCLUSIONS: GC exposure is associated with significant and consistent deterioration in TBS across diverse subgroups. Combining TBS with aBMD is recommended for assessing the bone health in patients treated with GC.
- Publisher Full Text (DOI)
- Large language models in rheumatology-centered research: A scoping review of model openness and reporting practices. [Review]Semin Arthritis Rheum. 2026 May 09; :152994. [Online ahead of print]SA
- CONCLUSIONS: LLM-based rheumatology research largely depends on closed models with inconsistent reporting of reproducibility-critical details and minimal code sharing. Clearer reporting practices and, in the longer term, consensus-based standards will be needed to strengthen the methodological robustness of this field.
- Publisher Full Text (DOI)
- Gender influence on ultrasound-assessed therapeutic response in rheumatoid arthritis: Insights from the GENder on UltraSound (GENUS) study. [Journal Article]Semin Arthritis Rheum. 2026 May 16; 79:152993. [Online ahead of print]SA
- CONCLUSIONS: . These results suggest that the short-term ultrasound-assessed response to targeted therapy in RA patients is similar in women and men.
- Publisher Full Text (DOI)
- Risk of second primary cancer and death in patients with idiopathic inflammatory myopathies. [Journal Article]Semin Arthritis Rheum. 2026 Jun; 78:152997.SA
- CONCLUSIONS: These findings provide new insight into the burden of subsequent cancers among IIM cancer survivors and highlight the need for close clinical monitoring for patients with dermatomyositis to reduce premature mortality.
- Publisher Full Text (DOI)
- Long-term risk of total joint replacement associated with second-line glucose-lowering therapies in type 2 diabetes: A population-based retrospective cohort study. [Journal Article]Semin Arthritis Rheum. 2026 May 08; 79:152995. [Online ahead of print]SA
- CONCLUSIONS: Among patients with T2DM initiating second-line glucose-lowering therapy, SGLT2i use was associated with more favorable OA-related outcomes, most consistently in comparison with GLP-1 RA. Comparisons with DPP4i were less consistent and were mainly limited to OA diagnostic outcomes rather than total joint replacement. These associations were more evident for knee-related than for hip-related outcomes, suggesting that the choice of second-line antidiabetic therapy may be associated with differences in clinically meaningful OA-related outcomes in real-world practice.
- Publisher Full Text (DOI)
- Hospitalization risk in patients with rheumatoid arthritis-associated interstitial lung disease or bronchiectasis: A matched cohort study. [Journal Article]Semin Arthritis Rheum. 2026 Jun; 78:152996.SA
- CONCLUSIONS: RA-ILD and RA-BR were each associated with markedly higher risks of overall and respiratory hospitalization than RA-no LD comparators. Factors including the MUC5B promoter variant and glucocorticoid use may place patients at higher risk for acute care utilization. These findings support early risk stratification and proactive monitoring to guide personalized RA-LD management.
- Publisher Full Text (DOI)
- Correspondence on "Central sensitization has major impact on quality of life in patients with axial spondyloarthritis" By Kieskamp et al. [Letter]Semin Arthritis Rheum. 2026 Jun; 78:152988.SA
- Publisher Full Text (DOI)
- Validity and reliability of hand-held dynamometry for proximal strength assessment in systemic sclerosis-associated myopathy. [Journal Article]Semin Arthritis Rheum. 2026 Jun; 78:152990.SA
- CONCLUSIONS: Hand-held dynamometry provides a quantitative assessment of proximal isometric strength in SSc-AM and demonstrated excellent intra-rater reproducibility in this study. Correlation with MMT-8 and MMT-3 demonstrates alignment with commonly used strength measures. Given known limitations of MMT-based assessment and variable inter-rater reproducibility, further longitudinal studies are needed to evaluate responsiveness and define its clinical utility.
- Publisher Full Text (DOI)
- Response to letter concerning article entitled "Central sensitization has major impact on quality of life in patients with axial spondyloarthritis. [Letter]Semin Arthritis Rheum. 2026 Jun; 78:152987.SA
- Publisher Full Text (DOI)
- Epicardial fat as a cardiovascular risk factor in inflammatory arthritis. [Journal Article]Semin Arthritis Rheum. 2026 Jun; 78:152985.SA
- CONCLUSIONS: Higher EFV in SpA and its association with inflammatory markers and coronary atherosclerosis highlight the increased CV risk in this population.
- Publisher Full Text (DOI)
- A systematic approach to the consensus definitions and reliability of ultrasound in idiopathic inflammatory myopathies; Preliminary data by the OMERACT ultrasound in myositis working group. [Multicenter Study]Semin Arthritis Rheum. 2026 Jun; 78:152984.SA
- CONCLUSIONS: The systematic approach by the OMERACT US in the myositis subgroup has developed a categorical morphological scoring system, which showed moderate inter-rater reliability using consensus-derived definitions of US domains in IIM.
- Publisher Full Text (DOI)
- Superior drug retention of selective JAK1 inhibitors compared to pan-JAK inhibitors in rheumatoid arthritis: A meta-analysis of real-world evidence. [Systematic Review]Semin Arthritis Rheum. 2026 Jun; 78:152989.SA
- CONCLUSIONS: Real-world evidence indicates that selective JAK1 inhibitors offer better drug retention than pan-JAK inhibitors in RA patients, primarily due to sustained effectiveness rather than differences in safety profiles.
- Publisher Full Text (DOI)