(Arthritis and Rheumatism[TA])
20,797 results
  • Interstitial lung disease in mixed connective tissue disease: Insights from an electronic health record-based retrospective cohort study. [Journal Article]
    Semin Arthritis Rheum. 2026 Jul 11; 80:153043. [Online ahead of print]Haussmann AJ, Chin AT, … Volkmann ERSA
  • CONCLUSIONS: ILD affected roughly half of patients with MCTD in this EHR-based cohort. PH and older age were independently associated with ILD, suggesting that patients with these features may warrant heightened pulmonary surveillance. Survival analyses were hypothesis-generating, with ILD associated with numerically higher mortality that did not reach statistical significance. Structured EHR methods can delineate real-world disease patterns in rare systemic autoimmune disease like MCTD. Standardized classification and routine pulmonary screening may enable earlier recognition and targeted intervention.
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  • Interobserver variability in synovial tissue biopsy markers in Rheumatoid Arthritis: Results from OMERACT special interest group on synovial tissue biopsy. [Journal Article]
    Semin Arthritis Rheum. 2026 Jun 30; 80:153041. [Online ahead of print]Ferraioli M, Small A, … OMERACT Synovial Tissue Biopsy Special Interest GroupSA
  • CONCLUSIONS: This study demonstrates that consensus-based methods can improve interobserver agreement in ST histology and IHC scoring across centres. Adoption of a maximum-score approach among observers represents a further step toward standardization of ST biopsy analysis, and may support its broader application STATEMENT OF CLINICAL SIGNIFICANCE: Histological and immunohistochemical analysis of synovial tissue (ST) biopsy is a promising tool in rheumatoid arthritis (RA), both in translational and clinical research. Notably, the differences in ST biopsy evaluation and interpretation persist across different centres of excellence hampers its widespread clinical application and use in multicentre trials. Our study demonstrates that consensus-based approaches, particularly the adoption of a maximum-score principle, can improve interobserver agreement of ST scoring across centres. Our findings represent a critical step toward the standardization of ST biopsy analysis.
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  • Efficacy and safety of Janus kinase inhibitors in Behçet's disease: A systematic literature review. [Review]
    Semin Arthritis Rheum. 2026 Jul 06; 80:153040. [Online ahead of print]Hassan F, Omar M, … Naffaa MESA
  • CONCLUSIONS: JAK inhibitors demonstrate promising efficacy in BD, particularly in refractory and multisystem disease. The most consistent evidence of efficacy was observed in gastrointestinal involvement, whereas data for other disease domains remain limited. Their safety profile appears consistent with existing data, although further follow up and validation is required. High-quality randomized controlled studies are an imminent need to study the potential role of JAK inhibitors in BD.
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  • Postoperative complications and outcomes after surgical treatment for tophaceous gout: A systematic review and meta-analysis. [Review]
    Semin Arthritis Rheum. 2026 Jun 30; 80:153038. [Online ahead of print]Xie RZ, Li XS, … Su YXSA
  • CONCLUSIONS: Surgical treatment for tophaceous gout is associated with measurable postoperative risks, particularly infection and overall complications. These findings support careful perioperative counseling, structured postoperative surveillance, integrated long-term urate-lowering management, and more standardized reporting of perioperative risk factors and postoperative outcomes in future surgical studies of tophaceous gout.
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