(BJR[TA])
20,075 results
  • Targeting AHNAK ameliorates osteonecrosis of the femoral head and affects adipogenic pathways involving Smad/PPARγ. [Journal Article]
    Bone Joint Res. 2026 Aug 19; 15(8):1042-1054.Chen MF, Hu CC, … Chang YBJ
  • CONCLUSIONS: AHNAK is a critical mediator of ischaemia-induced adipogenesis in ONFH through activation of the Smad/PPARγ signalling pathway, promoting the differentiation of preosteoblasts into adipocytes. Targeting AHNAK may offer a novel therapeutic strategy to reduce bone loss and marrow fat accumulation in ONFH, particularly in cases associated with steroids or metabolic dysfunction. Further studies are warranted to validate AHNAK as a clinical target.
  • Integrating Cardiovascular Screening in Lung Cancer Screening. [Journal Article]
    Br J Radiol. 2026 Aug 17. [Online ahead of print]Mozafary M, Rezaeifar M, … Raggi PBJ
  • Cardiovascular risk assessment is a natural extension of lung cancer screening (LCS) because individuals eligible for low-dose computed tomography often carry a high burden of cardiovascular risk, and cardiovascular disease remains a major competing cause of morbidity and mortality. The same examination can provide clinically relevant cardiovascular information, particularly through coronary arte…