- Antimicrobial-laden PerOssal beads display in vitro inhibition and killing of extensively drug-resistant Gram-negative bacteria associated with conflict wounds in Ukraine. [Journal Article]Bone Joint Res. 2026 Aug 20; 15(8):1055-1066.BJ
- CONCLUSIONS: Antimicrobial-laden PerOssal hydroxyapatite and calcium sulphate beads displayed in vitro inhibition and killing of XDR Gram-negative bacteria associated with contaminated traumatic wounds. Early local antimicrobial delivery may reduce infection risk following heavily contaminated open fractures, particularly when surgical wound excision is delayed. This may be relevant to both modern conflict and civilian disaster settings. Further work is required to determine the effectiveness of this approach in vivo.
- Publisher Full Text (DOI)
- Targeting AHNAK ameliorates osteonecrosis of the femoral head and affects adipogenic pathways involving Smad/PPARγ. [Journal Article]Bone Joint Res. 2026 Aug 19; 15(8):1042-1054.BJ
- CONCLUSIONS: AHNAK is a critical mediator of ischaemia-induced adipogenesis in ONFH through activation of the Smad/PPARγ signalling pathway, promoting the differentiation of preosteoblasts into adipocytes. Targeting AHNAK may offer a novel therapeutic strategy to reduce bone loss and marrow fat accumulation in ONFH, particularly in cases associated with steroids or metabolic dysfunction. Further studies are warranted to validate AHNAK as a clinical target.
- Publisher Full Text (DOI)
- Clinical Value of MRI in Radiation-Associated Angiosarcoma of the Breast: Assessment of Baseline and Post-Neoadjuvant Disease. [Journal Article]Br J Radiol. 2026 Aug 18. [Online ahead of print]BJ
- CONCLUSIONS: MRI has clinical value in assessing RAASB with the potential for significantly altering surgical management. In this small cohort, post-neoadjuvant MRI demonstrated limited additional clinical value. Larger studies are needed to define the optimal role and timing of post-neoadjuvant MRI.
- Publisher Full Text (DOI)
- Integrating Cardiovascular Screening in Lung Cancer Screening. [Journal Article]Br J Radiol. 2026 Aug 17. [Online ahead of print]BJ
- Cardiovascular risk assessment is a natural extension of lung cancer screening (LCS) because individuals eligible for low-dose computed tomography often carry a high burden of cardiovascular risk, and cardiovascular disease remains a major competing cause of morbidity and mortality. The same examination can provide clinically relevant cardiovascular information, particularly through coronary arte…
- Publisher Full Text (DOI)
- Intravenous Contrast Media-Related Variations in CT-Derived Body Composition Metrics: Associations With Sex and Adipose Tissue. [Journal Article]Br J Radiol. 2026 Aug 17. [Online ahead of print]BJ
- CONCLUSIONS: Lower precontrast SFA in women and higher IMAT proportion in men were associated with greater muscle enhancement.
- Publisher Full Text (DOI)
- In vivo quantification of polyethylene wear in total ankle arthroplasty : a longitudinal study using weightbearing CT. [Journal Article]Bone Joint Res. 2026 Aug 18; 15(8):1033-1041.BJ
- CONCLUSIONS: Using a WBCT-based approach, this study enabled longitudinal in vivo quantification of PE wear in TAA. Wear rates (~11.3 mm³/year) aligned with prior estimates, and the method correctly identified anticipated predictors of increased wear.
- Publisher Full Text (DOI)
- Artificial Intelligence Standardizes Pericoronary Fat Attenuation Index Measurement: External Multi-Vendor CT Validation. [Journal Article]Br J Radiol. 2026 Aug 17. [Online ahead of print]BJ
- CONCLUSIONS: AI-FAI demonstrates favorable agreement with traditional workstation-FAI, solid diagnostic performance, and consistent cross-scanner robustness, providing a reliable automated tool for cardiovascular risk assessment.
- Publisher Full Text (DOI)
- Piezo1 drives fibroblast activation in epidural fibrotic remodelling via the ET-1/HIF-1α pathway. [Journal Article]Bone Joint Res. 2026 Aug 17; 15(8):1017-1032.BJ
- CONCLUSIONS: These results highlight the critical role of the Piezo1/ET-1/HIF-1α pathway in epidural fibrotic remodelling. Targeting Piezo1 may offer a promising therapeutic strategy for alleviating epidural fibrosis and improving outcomes after spinal surgery.
- Publisher Full Text (DOI)
- Comparison of 68Ga-FAPI PET/CT and 18F-FDG PET/CT in Gastric Cancer: Impact on Metastatic Detection and Stage Migration. [Journal Article]Br J Radiol. 2026 Aug 14. [Online ahead of print]BJ
- CONCLUSIONS: [68]Ga-FAPI PET/CT improves detection of metastatic disease, particularly peritoneal involvement, compared with [18]F-FDG PET/CT in patients with gastric cancer and may contribute to more accurate disease staging.
- Publisher Full Text (DOI)
- Peak Uptake Value on Positron Emission Mammography Addresses Biopsy Sampling Limitations in Stratifying Proliferative Activity of Malignant Non-Mass Enhancement. [Journal Article]Br J Radiol. 2026 Aug 13. [Online ahead of print]BJ
- CONCLUSIONS: PEM-derived PUVmax shows high concordance with surgical pathology and may provide a reliable whole-lesion functional biomarker of high-risk biology in malignant NME.
- Publisher Full Text (DOI)
- Determination of institute specific CTV to PTV prostate margins using the 2020 BIR IGRT geometric uncertainty guidelines for a conventional linear accelerator. [Journal Article]Br J Radiol. 2026 Aug 13. [Online ahead of print]BJ
- CONCLUSIONS: Systematic errors contributed substantially to the overall margin particularly due to the magnitude of delineation errors. The margin calculated was smaller than the previously set institutional margin and ensures coverage of the PTV by the 95% isodose for 90% of prostate treatments at our centre.
- Publisher Full Text (DOI)
- A novel diagnostic technology rapidly detects the presence of infection and defines antimicrobial sensitivities in organisms typical for joint infection. [Journal Article]
- CONCLUSIONS: SLIC rapidly determines the presence of infection and characterizes antimicrobial susceptibilities in organisms typical for joint infection.
- PMC Free PDF
- In vitro evaluation of vancomycin-loaded Marlex mesh against staphylococci isolated from periprosthetic joint infection. [Journal Article]
- CONCLUSIONS: Compared with single-layer vancomycin-loaded mesh, multilayer vancomycin-loaded mesh, which mimics clinical application, provides enhanced and sustained antibacterial activity in vitro.
- PMC Free PDF
- The Diagnostic Utility of Multiphase-CT (4D CT) in Localising Parathyroid Adenomas Following Negative or Discordant 99mTc-Sestamibi SPECT/CT and Ultrasound Imaging. [Journal Article]Br J Radiol. 2026 Aug 12. [Online ahead of print]BJ
- CONCLUSIONS: Multiphase CT provided reliable diagnostic accuracy for localisation and lateralisation of parathyroid adenomas in the context of discordant or negative first-line imaging. Its high specificity and moderate positive likelihood ratios make it a valuable rule-in tool that enables targeted surgical approaches.
- Publisher Full Text (DOI)