- Acute lung injury and progressive pulmonary fibrosis following chlorotrifluoroethylene inhalation: insights from a case. [Journal Article]Clin Toxicol (Phila). 2026 Jul 06; :1-2. [Online ahead of print]CT
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- Suspected serotonin toxicity following combined nefopam and tramadol use in an older adult. [Journal Article]Clin Toxicol (Phila). 2026 Jul 06; :1-2. [Online ahead of print]CT
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- Serum benzylpenicillin levels during treatment for amatoxin poisoning: pharmacokinetic support for OATP1B3 inhibition. [Journal Article]Clin Toxicol (Phila). 2026 Jul 03; :1-9. [Online ahead of print]CT
- CONCLUSIONS: Continuous intravenous infusion of benzylpenicillin achieves serum concentrations exceeding the in vitro OATP1B3 inhibitory threshold in patients with amatoxin poisoning, providing human pharmacokinetic support for its proposed antidotal mechanism and its continued inclusion in multimodal treatment protocols.
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- Unlabeled kratom alkaloids detected in products marketed as kava. [Journal Article]Clin Toxicol (Phila). 2026 Jun 30; :1-4. [Online ahead of print]CT
- CONCLUSIONS: Unrecognized exposure to opioid-active kratom compounds may occur through products marketed as kava, highlighting the need for improved surveillance and increased awareness.
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- Contemporary survey of United States poison center treatment recommendations for sodium channel blocking drug poisoning. [Journal Article]Clin Toxicol (Phila). 2026 Jun 29; :1-6. [Online ahead of print]CT
- CONCLUSIONS: Sodium bicarbonate recommendations continue to focus heavily on electrocardiogram changes, with exact thresholds depending on patient and drug exposure factors. Further studies are needed to evaluate the optimal approach to sodium channel blocking drug poisoning.
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- Safety of acetylcysteine: a scoping review of iatrogenic overdose cases and their associated complications. [Review]Clin Toxicol (Phila). 2026 Jun 29; :1-12. [Online ahead of print]CT
- CONCLUSIONS: Iatrogenic acetylcysteine overdose is associated with high morbidity and mortality, with cerebral edema at very large doses contributing to rapid clinical deterioration, and frequently, death. In patients who survive longer, complications such as hemolytic uremia syndrome were observed. Evidence from this review supports the consideration of safety-focused changes in acetylcysteine administration protocols, including the adoption of simplified dosing regimens, improved electronic medical records, safeguards, and early targeted interventions. Standardizing monitoring protocols may further mitigate preventable harm in both traditional and expanded use cases.
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- Portal venous gas after ingestion of concentrated hydrogen peroxide. [Journal Article]Clin Toxicol (Phila). 2026 Jun 26; :1-3. [Online ahead of print]CT
- CONCLUSIONS: Hydrogen peroxide ingestion may result in corrosive injury and extensive portal venous gas. Early imaging and endoscopic assessment are important, and hyperbaric oxygen therapy may be considered in selected patients.
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- Rhabdomyolysis, renal failure and chronic neurologic deficits after prolonged immobilization from use of a 7-hydroxymitragynine product. [Journal Article]Clin Toxicol (Phila). 2026 Jun 26; :1-2. [Online ahead of print]CT
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- Comment on the effects of hyperbaric oxygen dosing on the delayed neuropsychiatric sequalae of carbon monoxide poisoning. [Journal Article]Clin Toxicol (Phila). 2026 Jun 24; :1-2. [Online ahead of print]CT
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- Survival from extreme methemoglobinemia due to intentional sodium nitrite poisoning. [Journal Article]Clin Toxicol (Phila). 2026 Jun 24; :1-3. [Online ahead of print]CT
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- Deliberate self-poisoning in four European countries: retrospective analysis of poison centre data. [Journal Article]Clin Toxicol (Phila). 2026 Jun 24; :1-10. [Online ahead of print]CT
- CONCLUSIONS: Deliberate self-poisoning represented a substantial proportion of poisoning cases, with a sharp rise after 2020, especially among children/adolescent females using readily available over-the-counter non-prescription medicines. These findings underscore the need for targeted prevention strategies and demonstrate the value of coordinated data collection. Expanding collaboration across additional countries could enhance monitoring, strengthen trend analyses, and inform public health interventions.
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- Cardiovascular effects associated with acute recreational drug toxicity presentations to the emergency department: a European drug emergencies network (Euro-DEN plus) study. [Journal Article]Clin Toxicol (Phila). 2026 Jun 23; :1-9. [Online ahead of print]CT
- CONCLUSIONS: Cardiovascular effects were present in almost a quarter of emergency department presentations with acute recreational drug toxicity, particularly involving cocaine and 3,4 methylenedioxymethamphetamine.
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- The features of toxic encephalopathy in a cohort of 129 patients with acute diquat poisoning. [Journal Article]Clin Toxicol (Phila). 2026 Jun 23; :1-14. [Online ahead of print]CT
- CONCLUSIONS: Thirty-four of 129 (26.4%) patients died from diquat poisoning. Toxic encephalopathy was diagnosed in 45 of 129 (34.9%) patients, and its development was associated with a significantly higher risk of death. Follow-up revealed peripheral nerve injuries in 20% of patients, and chronic-phase encephalopathy in 28%.
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- Lithium-associated adverse drug reactions: characteristics, possible etiologies, and preventability. [Journal Article]Clin Toxicol (Phila). 2026 Jun 23; :1-9. [Online ahead of print]CT
- CONCLUSIONS: Our findings indicate that most lithium-associated adverse drug reactions are preventable and influenced by several factors (e.g., age, eGFR, comorbidities, drug interactions, and dehydration) and that preventable adverse drug reactions result in more severe outcomes.
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- Frequency of massive diphenhydramine ingestions in children 6-18 years of age. [Journal Article]Clin Toxicol (Phila). 2026 Jun 18; :1-9. [Online ahead of print]CT
- CONCLUSIONS: The percentage of massive diphenhydramine ingestions ranged from 2.7-6.7% of reported ingestions from 2016-2023, and the trend since 2020 was not significantly increased. Massive diphenhydramine ingestions are associated with more severe symptoms and higher levels of care.
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