(Critical Care Medicine[TA])
27,793 results
  • Traumatic Inflammatory-Coagulation Coactivation Occurs Early After Injury and Impacts Mortality. [Journal Article]
    Crit Care Med. 2026 May 28. [Online ahead of print]Riccardi J, Robles AJ, … Callcut RACC
  • CONCLUSIONS: These findings demonstrate that coagulation and inflammation are coactivated early after severe injury and are associated with poor outcomes. The activation of these pathways is both complex and integrated, involving inflammatory cytokines, chemokines, growth factors, coagulation factors, platelet activated integrins, vWF, and thrombin. This study uses the largest comprehensive array of coagulation and inflammatory biomarkers to date and identifies key biologic phenotypes linked to mortality after severe trauma.
  • Publisher Full Text (DOI)
  • Survey of Intensivist Coverage and Interprofessional Team Staffing in Canadian ICUs. [Journal Article]
    Crit Care Med. 2026 May 28. [Online ahead of print]Wunsch H, Manoharan V, … Gershengorn HBCC
  • CONCLUSIONS: Most Canadian adult ICUs were staffed by intensivists with less than 25% having onsite intensivist coverage 24 hr/d. Physicians-in-training were present in the majority of ICUs, whereas APPs were uncommon. Nurses most commonly provided care for one mechanically ventilated patient each shift. These data establish contemporary staffing benchmarks to inform assessment of baseline ICU workforce needs and guide surge planning at local, provincial, and national levels. They also enable international comparisons and provide essential context for interpreting Canadian critical care research.
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  • Visual Right Ventricular Assessment in ICU: A Multicenter International Study. [Journal Article]
    Crit Care Med. 2026 May 22. [Online ahead of print]Levy D, Boutrot L, … Right Ventricle Eyeball Assessment by a Critical Care Team Organization Research (REACTOR) groupCC
  • CONCLUSIONS: Visual assessment of RV function by experienced raters shows satisfactory concordance with guideline-based FAC, supporting its integration into a multiparametric evaluation and structured educational programs.
  • Publisher Full Text (DOI)
  • Prognostic Value of Lung Injury Biomarkers in Patients Hospitalized With COVID-19 Without Respiratory Failure at Admission. [Journal Article]
    Crit Care Med. 2026 May 25. [Online ahead of print]Wilson JG, Grandits GA, … Strategies and Treatments for Respiratory Infections and Viral Emergencies (STRIVE) Network and Therapeutics for Inpatients with COVID-19 (TICO) Trial Study GroupCC
  • CONCLUSIONS: Baseline levels of plasma lung injury biomarkers are significantly associated with progression to respiratory failure or death among hospitalized COVID-19 patients without respiratory failure at admission. These findings support the potential utility of measuring lung injury biomarkers in patients hospitalized without respiratory failure and should be tested in more heterogeneous patient groups including non-COVID-19 cohorts.
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  • Cardiovascular Subphenotypes in Sepsis. [Journal Article]
    Crit Care Med. 2026 May 25. [Online ahead of print]Chotalia M, Ali M, … Bangash MNCC
  • CONCLUSIONS: Clustering analysis identified four cardiovascular subphenotypes in sepsis that reflected distinct circulatory failure mechanisms, were identifiable using simple models, and were associated with differing mortality risks and response to hemodynamic therapies. These classes may represent treatable traits to personalize shock management in sepsis.
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