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The 2026 British Society of Gastroenterology guidelines on the diagnosis and management of adult coeliac disease. [Journal Article]
Gut. 2026 Jul 12. [Online ahead of print]Penny HA, Shiha MG, … Guideline Consensus GroupGut
This document outlines an updated guideline from the British Society of Gastroenterology, detailing the standards for diagnosing and managing adult coeliac disease (CD). A multidisciplinary panel from across the UK, Sweden, Italy and Australia contributed to the development of these guidelines. This update is prompted by recent advancements in the diagnosis and treatment of adult CD. The primary …
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Piezo2[+] mechanosensory neurons and glial cells initiate resident macrophage activation in postoperative ileus. [Journal Article]
Gut. 2026 Jul 10. [Online ahead of print]Wang Z, Modave E, … Boeckxstaens GGut
CONCLUSIONS: Our findings reveal activation of Piezo2-expressing enteric neurons and EGCs as a very early step in IM-induced inflammation of POI. These cells subsequently activate mMfs resulting in upregulation of Ccl4, further amplifying the inflammatory cascade. These results highlight a key role for Piezo2 in the pathophysiology of POI.
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Risk-based pathology reporting after endoscopic submucosal dissection for early gastrointestinal cancer: international consensus standards. [Journal Article]
Gut. 2026 Jul 10. [Online ahead of print]Khalaf K, Li H, … Bechara RGut
CONCLUSIONS: These consensus standards provide immediately implementable, synoptic-ready pathology reporting criteria after ESD. By standardising measurement landmarks, margin terminology, ancillary stain use and reporting of adverse histological features, they aim to reduce interinstitutional variability, improve multidisciplinary decision-making and support future validation of risk models in early gastrointestinal cancer.
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Missing barrier in coeliac disease: why the gut vascular barrier matters. [Letter]
Gut. 2026 Jul 09. [Online ahead of print]Marlicz W, Koulaouzidis A, Rescigno MGut
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Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms. [Journal Article]
Gut. 2026 Jul 09. [Online ahead of print]Di Lorenzo B, Camargo Tavares L, … D'Amato MGut
CONCLUSIONS: This study provides the most comprehensive assessment of IBS genetics to date, demonstrating reproducible polygenic inheritance. We link IBS risk to convergent neurogastrointestinal and novel cardiometabolic mechanisms, highlight specific biological pathways and actionable mechanisms and outline translational opportunities emerging from integrated computational analyses.
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Outcome scoring systems for locoregional therapy in hepatocellular carcinoma: a systematic review. [Journal Article]
Gut. 2026 Jul 09. [Online ahead of print]Daruwalla C, Calderon E, … Hernaez RGut
CONCLUSIONS: Several outcome scoring systems are promising for specific LRTs and populations. However, most models have high risk of bias, underscoring the need for further development and validation.
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IL-10-neutralising autoantibodies in paediatric-onset inflammatory bowel disease. [Journal Article]
Gut. 2026 Jul 08. [Online ahead of print]Yalcinkaya A, Sandström E, … Landegren NGut
CONCLUSIONS: In paediatric autoimmune and inflammatory gut diseases, IL-10 neutralising autoantibodies were detected only among patients with IBD without known genetic aetiology. Patients had heterogeneous clinical characteristics and IL-10 autoantibodies persisted under standard immunosuppressive treatment but disappeared following HSCT and may have declined with colectomy or ileostomy. Screening for IL-10 autoantibodies via functional assays may identify a subgroup of patients with distinct aetiology and therapeutic needs.
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SMOC2 mediates GLI1+ mesenchymal cell-driven fibrostenosis and predicts postoperative recurrence in Crohn's disease. [Journal Article]
Gut. 2026 Jul 08. [Online ahead of print]Wang D, Zhao X, … Zou DGut
CONCLUSIONS: GLI1+ mesenchymal cells drive intestinal fibrostenosis through SMOC2-mediated niche formation. SMOC2 may serve as a predictive biomarker for postoperative recurrence and a potential therapeutic target for CD.
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Glucagon-like peptide-1 receptor agonists versus dipeptidyl peptidase-4 inhibitors after liver resection for hepatocellular carcinoma in patients with type 2 diabetes: a target trial emulation study. [Journal Article]
Gut. 2026 Jul 03. [Online ahead of print]Xiang YJ, Liu ZH, … Chinese Association of Liver Cancer and Chinese Medical Doctor AssociationGut
CONCLUSIONS: Postoperative GLP-1RA initiation, compared with DPP-4i initiation, was associated with delayed recurrence and longer OS; prospective confirmation is warranted.
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Dysregulated sphingolipid metabolismdrives pancreatic carcinogenesis through plasma membrane Kras enrichment. [Journal Article]
Gut. 2026 Jul 03. [Online ahead of print]Alnatsha A, Xu J, … Mahajan UMGut
CONCLUSIONS: In summary, SMPD1 regulated plasma membrane sequestration of Kras[G12D] represents a potential therapeutic target within the Kras signalling pathway for intractable PDAC.
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USP20 promotes CD8[+] T cell exhaustion and impairs KRAS[G12D] inhibitor efficacy by orchestrating cholesterol metabolism and autophagy in pancreatic cancer. [Journal Article]
Gut. 2026 Jul 02. [Online ahead of print]Yu Z, Qing H, … Jiao ZGut
CONCLUSIONS: USP20 acts as a critical metabolic checkpoint that orchestrates CD8[+] T cell exhaustion and therapeutic response. Targeting the USP20-cholesterol-autophagy axis represents a promising strategy to reverse immune suppression and unlock the full potential of KRAS[G12D] inhibitors in PDAC.
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