- RSV shapes serotype-specific invasive pneumococcal disease dynamics in children: an observational study. [Journal Article]J Infect Dis. 2026 Aug 04. [Online ahead of print]JI
- CONCLUSIONS: The role of RSV in triggering IPD strongly varies across pneumococcal serotypes. The impact of RSV-targeted interventions should be evaluated in light of these data.
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- Mucosal IgG Interacts with Herpes Simplex Virus Glycoprotein E, an Fcγ Receptor Mimetic, and Neutralizes Viral Infection: Activity is Reduced in the Setting of Vaginal Dysbiosis. [Journal Article]J Infect Dis. 2026 Jul 31. [Online ahead of print]JI
- CONCLUSIONS: Interactions between IgG Fc and viral gE, independent of Fab specificity, contribute to cervicovaginal antiviral activity. Antiviral activity is reduced with dysbiosis, presumably reflecting lower IgG levels and differences in N-glycans that lead to decreased gE interactions. Results highlight the importance of developing and implementing strategies to protect against vaginal dysbiosis.
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- Crisis as Catalyst: The future of the NIH driving scientific discovery. [Journal Article]J Infect Dis. 2026 Jul 31. [Online ahead of print]JI
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- Characterization of hepatitis B virus in blood donors who were disqualified based on testing: genotype distribution, infectivity, and replicative fitness in human hepatocytes. [Journal Article]J Infect Dis. 2026 Jul 31. [Online ahead of print]JI
- CONCLUSIONS: Analyses of plasma samples from HBV-infected individuals identified two groups differing in age, race, HBV genotype, and likely transmission route. HBV from anti-HBc non-reactive samples showed greater replicative fitness in HLCM-HH cultures compared to anti-HBc reactive samples.
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- Development of a High-Content Stem Cell Focused Drug Screening Platform for Schistosoma mansoni Using Developmentally Advanced Liver Schistosomula - Functional Insights and New Protein Target Leads. [Journal Article]J Infect Dis. 2026 Jul 31. [Online ahead of print]JI
- CONCLUSIONS: In addition to identifying a panel of new anti-schistosomal compounds with associated predicted targets, the findings provide mechanistic insights into the somatic stem cell biology of schistosomes. Further application of this platform, which offers a new approach to assessing compound susceptibility on schistosomula, should accelerate lead compound discovery to help fight human schistosomiasis.
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- Exosomal programmed death ligand 1 in patients with Mycobacterium avium complex lung disease. [Journal Article]J Infect Dis. 2026 Jul 30. [Online ahead of print]JI
- CONCLUSIONS: Exosomal PD-L1 promotes immune suppression and reflects disease severity in MAC-LD. Inhibition of exosome biogenesis reduced exosomal PD-L1 levels and MAC burden in lung, supporting a potential therapeutic avenue that requires further validation.
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- The Power of Public Science: Lessons from TV003 and Butantan-DV. [Journal Article]J Infect Dis. 2026 Jul 30. [Online ahead of print]JI
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- Integrated Methylome and Transcriptome Analysis in Chronic Chagas Cardiomyopathy Uncovers Alterations in Heart Development. [Journal Article]J Infect Dis. 2026 Jul 30. [Online ahead of print]JI
- CONCLUSIONS: Our findings highlight a systemic epigenetic signature in blood that reflects cardiac pathology in CCC. These insights advance our understanding of CCC pathogenesis and facilitate novel blood-based biomarkers and therapeutic targets aimed at preventing disease progression.
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- RNAemia and Severe COVID-19: Candidate Treatment Targets Identified Through Transcriptomics. [Journal Article]J Infect Dis. 2026 Jul 29. [Online ahead of print]JI
- CONCLUSIONS: RNAemia is an independent predictor of COVID-19 severity. However, host gene expression changes associated with RNAemia, particularly involving OLAH, PCSK9, and ADAMTS2, had stronger statistical evidence of severe outcomes than RNAemia itself. PCSK9 is an intervenable treatment target worth further study.
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- Correspondence to "Indirect Effect of Pneumococcal Conjugate Vaccines on Pneumococcal Colonization: Persistence and Dynamics of Vaccine Serotypes in Sicily (Italy) 11 Years Postintroduction, 2009-2020" by Tramuto et al. [Journal Article]J Infect Dis. 2026 Jul 29. [Online ahead of print]JI
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- CD4+ T cell markers associated with Treatment Outcomes in Tuberculosis: A Sub-analysis of a Phase IIB Trial of Acetylsalicylic acid and Ibuprofen as Adjunctive Therapy. [Journal Article]J Infect Dis. 2026 Jul 29. [Online ahead of print]JI
- CONCLUSIONS: CD4+ T cell subsets show promise as markers of disease severity and potential predictors of microbiological, clinical, and radiological outcomes in treated TB. However, the present findings are insufficient to support the routine use of ASA or IBU in adjunctive HDT regimens, and larger, targeted studies are warranted.
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- Epidemiology and Clinical Impact of Clonal Hematopoiesis in People with HIV. [Journal Article]J Infect Dis. 2026 Jul 28. [Online ahead of print]JI
- CONCLUSIONS: The study provides a comprehensive assessment of the CH landscape in PWH, highlighting potential causes and consequences in this population and suggesting an interaction between CH and chronic immune activation.
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- Metabolic Mechanisms of INSTI-Associated Weight Gain: A Multi-Omics Study in Male People with HIV. [Journal Article]J Infect Dis. 2026 Jul 27. [Online ahead of print]JI
- CONCLUSIONS: Our integrated multi-omics approach reveals that INSTI-based regimens induce universal metabolic changes. The change of thyroxine and the predictability of TTR in multi-omic studies show the critical role of thyroxine metabolism in INSTI-associated weight gain.
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- Hurt Immunity? Measles Increasing in the US Despite High Seroprevalence. [Journal Article]J Infect Dis. 2026 Jul 27. [Online ahead of print]JI
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