- Explainable AI in Cancer Imaging: Scoping Review of Methods, Modalities, and Clinical Integration. [Review]J Med Internet Res. 2026 May 20; 28:e80645.JM
- CONCLUSIONS: This scoping review maps xAI implementation across multiple cancer imaging modalities, revealing methodological inconsistency and insufficient validation. Most research emphasizes visualization over quantitative interpretability, and few models are reproducible or clinically implemented. These findings provide an evidence base for researchers, clinicians, and regulators to prioritize standardization of xAI reporting, quantitative validation, and user-centered frameworks to advance trustworthy AI in oncology imaging.
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- Receipt of Medicines Information From the Internet and Other Information Sources Among Adult Medicine Users in Developed Economies, 2010-2025: Systematic Review. [Review]J Med Internet Res. 2026 May 20; 28:e71984.JM
- CONCLUSIONS: Traditional MI sources remain central for adult medicine users despite the growing role of electronic platforms. While the receipt of MI from electronic sources appears more common among internet-experienced users, no significant temporal trends in using these sources were identified. Further research is needed to better distinguish between different digital MI sources, including artificial intelligence-based MI sources, and to explore their evolving roles, implications for health-related decision-making, and associations with user characteristics and health contexts in the digital era. This review is innovative in systematically comparing traditional and electronic MI sources across developed economies and in highlighting methodological and conceptual gaps in existing research. By synthesizing cross-national evidence and identifying the need for clearer differentiation of digital MI subtypes, the study contributes to the field and informs the development of more targeted, reliable, and user-centered MI strategies in real-world health care settings.
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- A Digital Toolkit for Weight Loss Maintenance in European Adults (NoHoW): 2×2 Factorial Randomized Controlled Trial. [Randomized Controlled Trial]J Med Internet Res. 2026 May 20; 28:e69634.JM
- CONCLUSIONS: The NoHoW trial was the first large-scale, multicountry 2×2 factorial randomized controlled trial to evaluate a digital-only toolkit based on self-regulation or motivation and emotion regulation techniques for weight loss maintenance. NoHoW found no evidence in the primary ITT analysis that digital interventions targeting self-regulation or emotion regulation improved weight loss maintenance compared with the active control. A small subgroup effect in men should be interpreted cautiously and does not change this conclusion. The trial provides evidence on both the limitations and potential of digital behavior change interventions for long-term weight outcomes. Future digital interventions may benefit from enhanced engagement and tailored content to improve long-term weight outcomes.
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- Virtual Consultations for People With Intellectual Disabilities in General Practice and Community Care: Mixed Methods Qualitative Study. [Journal Article]J Med Internet Res. 2026 May 20; 28:e81173.JM
- CONCLUSIONS: VCs offer an opportunity to improve digital inclusion in health care for people with intellectual disabilities. However, the quality and safety of VCs for this population are dependent on continuous review of patients' needs over time and ensuring that their choices and preferences are considered when planning and providing ongoing care.
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- Alignment Between Cardiologists and AI-Driven Diagnostic Systems: Mixed Methods Study. [Multicenter Study]J Med Internet Res. 2026 May 20; 28:e83541.JM
- CONCLUSIONS: EGP shows promise as an adjunctive tool but struggles with multimorbid patients and exhibits high, uneven rejection rates. Cardiologists use AI to prompt scrutiny, not replace judgment. Future systems need to integrate wider patient data with imaging and minimize bias through representative training to avoid exacerbating inequities.
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- Frailty-Based Remote Monitoring in Older Adults With Heart Failure: Conceptual Framework for Adaptive Digital Health Strategies. [Journal Article]J Med Internet Res. 2026 May 20; 28:e88681.JM
- Remote monitoring is increasingly used in heart failure care, but most programs rely on uniform models that insufficiently reflect the heterogeneity of older adults, particularly with respect to frailty, cognitive impairment, functional dependency, and caregiver availability. This viewpoint argues that frailty should be considered a central determinant of remote monitoring design in older adults …
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- Development of a Validated Lay Checklist (Info Without Side Effects) for Assessing Health Information on Websites: Mixed Methods Study. [Journal Article]J Med Internet Res. 2026 May 20; 28:e69529.JM
- CONCLUSIONS: The iWISE checklist represents a user-friendly, validated tool for evaluating the trustworthiness of health information about interventions on websites. With only 7 items, it is easy to remember and could significantly improve critical health literacy. Future research should test its reliability for social media posts and health information videos.
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- Women's Engagement With Different Internet-Enabled Technologies to Access Digital Menopause Information: Mixed Methods, Multiphase Sequential Study. [Journal Article]J Med Internet Res. 2026 May 20; 28:e78215.JM
- CONCLUSIONS: It is important to consider how individuals engage with several different internet-enabled technologies for menopause information rather than investigating one at a time. This study highlights the nuances across websites, podcasts, and online groups or forums in terms of familiarity, accessibility, trust, and lived experience.
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- Health Information Adoption Among Patients With Chronic Disease in China: Qualitative Interview Study of Patient-Platform Coshaping. [Journal Article]J Med Internet Res. 2026 May 20; 28:e85229.JM
- CONCLUSIONS: This study proposes a theoretical model that explores how the interaction between digital platforms and patients influences health information adoption. By adopting an interpretive approach and introducing the patient-platform coconstruction perspective, this research extends existing health information behavior theories to account for platform-era dynamics. The model highlights the crucial role of platforms in structuring patients' ongoing health information practices, providing insights for the design, governance, and optimization of digital health platforms to better support chronic disease self-management.
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- Use of Health and Well-Being Technology, Basic Psychological Needs, and the Mediating Role of Technological Identity in 6 European Countries: Prospective Longitudinal Survey Study. [Journal Article]J Med Internet Res. 2026 May 19; 28:e83054.JM
- CONCLUSIONS: Unlike most existing studies, this research focuses on the technology-related psychological effects of everyday health and well-being technologies and provides longitudinal and cross-national evidence of how they shape broader outcomes beyond health content and goals. The findings demonstrate that health technologies can both support users' social needs and undermine their personal sense of agency. They also provide insights into the significance and dual-edged role of technology users' social identity in transmitting these effects. The study highlights the central role of technology-related basic needs and identity processes in understanding the larger outcomes of rapidly advancing digital health technologies. It offers valuable insights for health technology designs and implementations that aim to enable need-supportive technology engagement.
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- Human Papillomavirus Vaccine Discourse and Sentiment on Reddit Before and After COVID-19: Mixed Methods Retrospective Cross-Sectional Study. [Journal Article]J Med Internet Res. 2026 May 19; 28:e83558.JM
- CONCLUSIONS: This study provides a post-COVID-19 perspective on patient-generated HPV vaccine discourse by integrating thematic content with sentiment and temporal trends. Prior studies have been limited by a narrower thematic scope and have focused on prepandemic periods. By examining discussions on an anonymous platform such as Reddit, this analysis captures personal conversations and assesses pandemic-related shifts in discourse. These findings add to the literature on digital vaccine communication and highlight opportunities for targeted public health engagement and strategies to leverage online communities.
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- Understanding Remission of Long-Term Conditions Through Electronic Health Records: Scoping Review. [Review]J Med Internet Res. 2026 May 19; 28:e80796.JM
- CONCLUSIONS: This review demonstrates that remission of LTCs can be identified and operationalized within EHRs, although remission criteria varied across studies. The review extends the literature on remission in EHRs by combining evidence synthesis and consultation with clinical and data experts to propose standardized comprehensive definitions to reliably define and implement remission of multiple LTCs in EHR-based research. This will allow cross-study comparisons and present an opportunity to advance understanding of disease trajectories and improve evaluation and monitoring of patient outcomes. Further research may apply, compare, and evaluate standardized definitions across different data sources to assess generalizability and further improve our understanding of remission of LTCs.
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- Nicotine Dependence and Quit Self-Confidence in a Smoking Cessation Program Using a Group-Based Digital Peer-Supported App and Cigarette Consumption-Adjusted Nicotine Aids Among Japanese Workers: Retrospective Cohort Study. [Journal Article]J Med Internet Res. 2026 May 19; 28:e84792.JM
- CONCLUSIONS: By distinguishing cigarette-only smokers, heated tobacco product-only users, and dual users in a workplace cessation program, this study provides novel, product-specific evidence regarding nicotine dependence and self-confidence related to cessation success. This study extends prior research beyond cigarette-only smokers by examining tobacco user groups and suggests that self-confidence may predict cessation across tobacco product types, whereas the role of nicotine dependence may be product-specific. These findings may inform tailored, scalable smoking-cessation support in workplaces; however, they should be interpreted with caution because cessation outcomes were self-reported.
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- Co-Lifecycle Governance for Learning Medical AI: A Hybrid Convergence Framework for Adaptive Regulatory Oversight. [Journal Article]J Med Internet Res. 2026 May 19; 28:e90654.JM
- Artificial intelligence (AI) in health care is increasingly defined not by static algorithms but by adaptive intelligence-systems that evolve over time through interactions with data, clinicians, and clinical environments. This adaptive capacity creates a structural mismatch with regulatory frameworks built for technologies whose behavior remains static. As AI models drift, recalibrate, or degrad…
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- Why People Conceal Mental Health Problems: Qualitative Analysis of TikTok Posts. [Journal Article]J Med Internet Res. 2026 May 19; 28:e88244.JM
- CONCLUSIONS: Results provide insight into patient motivations for concealing their suicidal thoughts and behaviors and offer potential avenues for improving rates of disclosure, which is critical to reducing death by suicide. TikTok creators frequently described concealment as a strategy to avoid perceived punitive consequences, manage interpersonal dynamics, or cope with emotional distress. Findings suggest that current risk management practices and stigma surrounding psychiatric care may unintentionally reinforce concealment behaviors. These insights may inform interventions aimed at improving the therapeutic alliance, enhancing transparency around hospitalization criteria, and reducing barriers to honest reporting of suicide risk.
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