- A step forward for precision oncology in thyroid cancer. [Journal Article]Lancet Oncol. 2026 Jul 13. [Online ahead of print]LO
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- Efficacy and safety of dabrafenib plus trametinib in adults with differentiated thyroid cancer: a randomised, double-blind, placebo-controlled, phase 3 trial. [Journal Article]Lancet Oncol. 2026 Jul 13. [Online ahead of print]LO
- CONCLUSIONS: In previously-treated patients with locally advanced or metastatic, radioactive iodine-refractory BRAF[V600E]-positive differentiated thyroid cancer, dabrafenib plus trametinib showed significant benefits for progression-free survival and overall response rate, with no new safety signals. These findings support the second-line use of dabrafenib plus trametinib in patients with radioactive iodine-refractory BRAF[V600E]-positive differentiated thyroid cancer.
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- Switching to camizestrant at ESR1 mutation emergence before disease progression during first-line treatment of hormone receptor-positive advanced breast cancer (SERENA-6): extended analysis of a double-blind, placebo-controlled, randomised, phase 3 trial. [Journal Article]Lancet Oncol. 2026 Jul 13. [Online ahead of print]LO
- CONCLUSIONS: Switching to camizestrant plus CDK4/6 inhibitor at ESR1 mutation emergence, versus continuing aromatase inhibitor plus CDK4/6 inhibitor, resulted in sustained progression-free survival benefit that translated into a statistically significant improvement in second progression-free survival. These results further support switching endocrine treatment to camizestrant from aromatase inhibitor upon detection of ESR1 mutation, with continuation of any of the globally approved CDK4/6 inhibitor, to extend first-line treatment benefit.
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- Now or later? Switching therapies in metastatic breast cancer. [Journal Article]Lancet Oncol. 2026 Jul 13. [Online ahead of print]LO
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- Single, early intravesical instillation of pirarubicin in the prevention of bladder recurrence after radical nephroureterectomy for upper tract urothelial carcinoma (JCOG1403): a multicentre, open-label, randomised, phase 3 trial. [Journal Article]Lancet Oncol. 2026 Jul 10. [Online ahead of print]LO
- CONCLUSIONS: A single, postoperative pirarubicin instillation after radical nephroureterectomy is an efficacious treatment with manageable adverse events to reduce recurrence in patients with upper tract urothelial carcinoma.
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- Intravesical pirarubicin after nephroureterectomy. [Journal Article]Lancet Oncol. 2026 Jul 10. [Online ahead of print]LO
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- Gastric cancer with peritoneal metastases: hype or hope for HIPEC? [Journal Article]Lancet Oncol. 2026 Jul 08. [Online ahead of print]LO
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- Systemic therapy, gastrectomy, cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy versus systemic therapy alone for gastric cancer with limited peritoneal metastases (PERISCOPE II): final results of a multicentre, randomised, controlled, phase 3 trial after an unplanned commissioned interim analysis. [Journal Article]Lancet Oncol. 2026 Jul 08. [Online ahead of print]LO
- CONCLUSIONS: Gastrectomy with cytoreductive surgery and HIPEC provided no survival benefit in patients with gastric cancer and limited peritoneal metastases compared with systemic therapy alone.
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- Somatostatin receptor PET response assessment framework for patients with neuroendocrine tumours (V1.0): a modified Delphi consensus from the European Neuroendocrine Tumor Society (endorsed by EANM and NANETS). [Review]Lancet Oncol. 2026 Jul 03. [Online ahead of print]LO
- Somatostatin receptor PET imaging is integral to the management of patients with neuroendocrine tumours (NETs), yet standardised criteria for therapy response assessment with the use of this modality are not available. This Policy Review reports the development of the European Neuroendocrine Tumor Society somatostatin receptor PET response assessment framework, established through a structured mo…
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- Differential impact of proton pump inhibitors and antibiotics on immunotherapy efficacy after chemoradiotherapy in locally advanced non-small-cell lung cancer: a post-hoc analysis of the PACIFIC trial. [Journal Article]Lancet Oncol. 2026 Jul 03. [Online ahead of print]LO
- CONCLUSIONS: Baseline exposure to proton pump inhibitors and antibiotics was associated with inferior outcomes with durvalumab, but not with placebo, consistent with potential attenuation of the benefit of durvalumab with proton pump inhibitors and antibiotics in patients with unresectable stage III NSCLC.
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- Co-medications and gut microbiome in NSCLC immunotherapy. [Journal Article]Lancet Oncol. 2026 Jul 03. [Online ahead of print]LO
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- Carcinogenicity of butyl benzyl phthalate, dibutyl phthalate, and diisononyl phthalate. [Journal Article]Lancet Oncol. 2026 Jul 03. [Online ahead of print]LO
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- New report sheds light on cancer disparities in the USA. [Journal Article]Lancet Oncol. 2026 Jul 02. [Online ahead of print]LO
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- Review highlights gaps in South Africa's cancer care. [Journal Article]Lancet Oncol. 2026 Jul 02. [Online ahead of print]LO
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- Neoadjuvant toripalimab plus celecoxib versus toripalimab monotherapy for mismatch repair-deficient or microsatellite instability-high, locally advanced colorectal cancer (PICC-2): an open-label, multicentre, randomised, phase 2 trial. [Journal Article]Lancet Oncol. 2026 Jul 01. [Online ahead of print]LO
- CONCLUSIONS: In patients with dMMR or MSI-H locally advanced colorectal cancer, neoadjuvant toripalimab plus celecoxib significantly increased the proportion of patients attaining pathological complete response compared with toripalimab monotherapy, with a similar safety profile. These findings support further investigation of this combination strategy in larger phase 3 trials.
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