- Exploring prevalence and drivers of perimenopause uncertainty among US Women: a mixed-methods study. [Journal Article]Menopause. 2026 Jul 14. [Online ahead of print]M
- CONCLUSIONS: Perimenopause uncertainty is a prevalent and clinically meaningful phenomenon. Conceptually distinct from illness-focused uncertainty, this universal transition frequently involves ambiguity and limited validation. Clarifying symptom patterns, addressing knowledge gaps, and reducing barriers to confirmation may support women during perimenopause.
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- Premature menopause and risk of kidney stone disease: evidence from the UK biobank and National Health and Nutrition Examination Survey. [Journal Article]Menopause. 2026 Jul 14. [Online ahead of print]M
- CONCLUSIONS: PM was consistently associated with KSD across two large cohorts. This association remained robust across multiple analytical approaches. Genetic predisposition was associated with higher hazards of KSD, whereas HT did not meaningfully modify these associations. These findings suggest a clinically relevant link that warrants further investigation in prospective and mechanistic studies.
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- Cumulative social determinants of health and reproductive lifespan among US women: a NHANES 1999-2018 analysis. [Journal Article]Menopause. 2026 Jul 14. [Online ahead of print]M
- CONCLUSIONS: Higher cumulative social disadvantage was associated with a shorter reproductive lifespan among women. Food security, housing status, education level, and PIR were important contributors within the SDoH mixture, highlighting the potential relevance of SDoH in reproductive aging.
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- Perception of prolapse-associated symptoms by age: a cross-sectional study. [Journal Article]Menopause. 2026 Jul 14. [Online ahead of print]M
- CONCLUSIONS: Vaginal bulge is the most common prolapse-associated symptom. POP-associated pelvic floor symptoms are experienced similarly across study participants, regardless of age, with the exception of stress urinary incontinence and pain.
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- Evolution of health-related quality of life after breast cancer surgery: longitudinal follow-up of climacteric symptoms. [Journal Article]Menopause. 2026 Jul 07. [Online ahead of print]M
- CONCLUSIONS: Between 6 and 12 months after surgery, climacteric symptom burden in breast cancer survivors showed minimal change. Although statistically significant differences were observed, these remained below the MCID and are therefore unlikely to represent clinically meaningful changes. These findings support the need for early, proactive, and multidisciplinary management strategies to optimize health-related quality of life during survivorship in this population.
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- Derivation and validation of a symptom-anchored diagnostic criterion for nocturnal polyuria in women: aligning with aging physiology. [Journal Article]Menopause. 2026 Jul 07. [Online ahead of print]M
- CONCLUSIONS: Current age-stratified thresholds of nocturnal polyuria result in discrepancies with aging physiology. The proposed framework establishes a physiologically plausible standard. By anchoring symptom bother score and nocturnal polyuria index of 28%, this definition facilitates the identification of symptomatic women and highlights the distinct impact of menopause.
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- Group-based compassionate mind training for low mood and anxiety in the menopause transition: a feasibility randomized controlled trial. [Journal Article]Menopause. 2026 Jul 07. [Online ahead of print]M
- CONCLUSIONS: The study supports the feasibility and acceptability of CMT for women in MT. Quantitative and qualitative findings suggest potential benefits for mental health and quality of life, warranting a fully powered trial of effectiveness and cost-effectiveness.
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- Age at natural and surgical menopause and related factors: NHANES 2013-2023. [Journal Article]Menopause. 2026 Jul 07. [Online ahead of print]M
- CONCLUSIONS: Differences between calculated associations and menopause timing reported in the literature are likely due to methodological and participant inclusion differences. The life table method demonstrates a similar estimate to the commonly reported value for natural menopause onset. Several modifiable factors may provide opportunities for intervention.
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- Menopause-associated pain: a decade review of patterns, determinants, and research priorities. [Journal Article]Menopause. 2026 Jul 07. [Online ahead of print]M
- CONCLUSIONS: Five major pain categories were identified: musculoskeletal, urogenital, gastrointestinal, oral/orofacial, and multisite or unspecified pain. Musculoskeletal and urogenital pain were most frequently studied. Pain severity was commonly reported to peak during early menopause and declined postmenopause, although trajectories vary by pain type and comorbidity. Across domains, psychological distress, sleep disturbance, body mass index, and social determinants of health consistently modified pain perception and functional impact. Evidence for management strategies was uneven; however, exercise-based interventions demonstrated the most consistent functional benefits. Evidence for hormone therapy and complementary approaches was heterogeneous and phenotype-dependent. Although research has become more phenotype-specific and biopsychosocial in orientation, methodological heterogeneity and geographic concentration limit generalizability. Harmonized measurement, longitudinal designs, and inclusive, rigorously conducted trials are needed to support equitable, patient-centered menopause pain management.
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- Regeneration of the structure and function of estrogen-deficient vaginal epithelium by a novel phytoestrogen-related compound. [Journal Article]Menopause. 2026 Jul 07. [Online ahead of print]M
- CONCLUSIONS: The combination of local delivery, modest potency, liver metabolism, and elimination creates safeguards that support the potential for human use of 3F to alleviate symptoms associated with estrogen-deficient vaginal atrophy without the risks of systemic hormone therapy or local steroidal estrogens.
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- Occupational quality of life during the menopause transition: a cross-sectional study of women faculty and staff at three universities in the United States. [Journal Article]Menopause. 2026 Jul 07. [Online ahead of print]M
- CONCLUSIONS: Workplace interventions may be needed to reduce the interference of symptoms with OQoL during the menopause transition.
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- Postmenopausal vasomotor symptoms are associated with heightened cutaneous vasodilation despite preserved nitric oxide-mediated endothelial function. [Journal Article]Menopause. 2026 Jul 07. [Online ahead of print]M
- CONCLUSIONS: Although postmenopausal females with VMS exhibit heightened cutaneous vasodilatory responses to local heating, NOS-dependent vasodilation is preserved. These findings suggest that enhanced microvascular reactivity in VMS is not attributable to altered endothelial NOS function.
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- Menopause experience among people with criminal legal system involvement. [Journal Article]Menopause. 2026 Jul 07. [Online ahead of print]M
- CONCLUSIONS: Women with a history of CLS involvement commonly experience menopausal symptoms, some of which are severe. These symptoms are experienced in the context of CLS involvement that may amplify barriers to accessing care.
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- Combined adductor pollicis muscle thickness and handgrip strength as predictive indicators for risk stratification of low muscle mass and low bone mass in adult women. [Journal Article]Menopause. 2026 Jun 30. [Online ahead of print]M
- CONCLUSIONS: The combined assessment of HGS and APMT captures complementary dimensions of musculoskeletal health and may serve as a practical approach for preliminary risk stratification, particularly in resource-limited settings where access to standard diagnostic methods, such as dual-energy x-ray absorptiometry, remains limited.
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- Novel and traditional anthropometric measures of obesity association with dynapenia in postmenopausal women. [Journal Article]Menopause. 2026 Jun 30. [Online ahead of print]M
- CONCLUSIONS: There were no associations between BMI, BRI, and ABSI with HGS. Furthermore, in postmenopausal women, dynapenia was also not associated with these anthropometric indices of obesity.
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