- A systematic review and meta-analysis of the effects of high-intensity, impact, and strength training on bone mineral density in premenopausal and postmenopausal women. [Journal Article]Menopause. 2026 Aug 11. [Online ahead of print]M
- CONCLUSIONS: High-intensity, impact, and strength training (pooled analysis) appeared to be effective at increasing bone mineral density in postmenopausal women, though the small effect sizes and methodological limitations identified should be considered. Further studies are required to determine whether more robust protocols would have generated stronger effects in premenopausal women, or whether there are different osteogenic responses to exercise in the two populations.
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- Combined social determinants of health, mortality, and adverse health outcomes in early natural menopause. [Journal Article]Menopause. 2026 Aug 11. [Online ahead of print]M
- CONCLUSIONS: Cumulative social disadvantage significantly amplifies the risks of mortality and multimorbidity in women with ENM. These findings warrant the integration of multidimensional SDH assessments into clinical management to tailor preventive strategies and mitigate disease burden in this vulnerable population.
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- Premature menopause and hypertension as combined risk factors for cardiovascular events in women: a nationwide cohort analysis. [Journal Article]Menopause. 2026 Aug 04. [Online ahead of print]M
- CONCLUSIONS: Coexisting PM and hypertension confer a markedly elevated risk of CVD beyond either factor alone. Menopausal age and hypertension should be integrated into CVD risk stratification and primary prevention strategies for postmenopausal women.
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- Inflammatory and immune biomarkers over midlife and future cognition in women: the SWAN HDL Ancillary Study. [Journal Article]Menopause. 2026 Aug 04. [Online ahead of print]M
- CONCLUSIONS: Higher baseline GlycA, rather than its changes since baseline, was associated with lower future working memory, whereas higher baseline complement factor 4 and increases in C3 and C4 since baseline appeared cognitively protective. Targeting inflammation amelioration and immunity improvement over the menopause transition may provide an open avenue to preserve future cognitive health.
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- Association between type 2 diabetes mellitus and menopausal symptoms among Korean midlife women. [Journal Article]Menopause. 2026 Aug 04. [Online ahead of print]M
- CONCLUSIONS: T2DM was significantly associated with the number and severity of menopausal symptoms among Korean midlife women. Postmenopausal women with T2DM also reported a greater menopausal symptom burden than those without T2DM. Tailored interventions may help managing symptom burden and improve overall quality of life in this population.
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- Efficacy of a probiotic formula in the management of menopausal symptoms and quality of life: a randomized controlled trial. [Journal Article]Menopause. 2026 Aug 04. [Online ahead of print]M
- CONCLUSIONS: In this real-world study, the probiotic formula was associated with improvements in menopause-associated symptoms and quality of life, whereas the global Cervantes score appeared to be similar between groups. Future investigations are required to confirm this clinical effect and the underlying mechanisms of action. ClinicalTrials.gov identifier: NCT06604234.
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- Menopause education in undergraduate medical curricula: a narrative review of teaching models, content gaps, and learner preparedness. [Journal Article]Menopause. 2026 Jul 28. [Online ahead of print]M
- CONCLUSIONS: The literature search identified 1,305 records, of which 12 studies met inclusion criteria. Menopause education was inconsistently incorporated into undergraduate medical curricula and often embedded within broader primary care teaching rather than delivered as structured content. Although students generally demonstrated accurate recognition of menopausal symptoms, many showed gaps in management and counseling skills. Menopause education in undergraduate medical curricula is inconsistently delivered and lacks standardization. Development of a structured, competency-based menopause curriculum for undergraduate medical education may improve learner preparedness to better care for menopause patients.
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- Weight loss interventions and sexual function in midlife women: the emerging role of glucagon-like peptide-1 receptor agonists. [Journal Article]Menopause. 2026 Jul 28. [Online ahead of print]M
- CONCLUSIONS: Obesity impairs female sexual function through hormonal, vascular, and psychosocial mechanisms. Accordingly, lifestyle interventions and bariatric surgery have demonstrated meaningful improvements in sexual function. In contrast, GLP-1 receptor agonists, despite conferring substantial weight loss and favorable metabolic effects, may paradoxically suppress sexual desire and arousal through central neuroendocrine mechanisms, including the modulation of dopaminergic reward and serotonergic signaling. While emerging case reports and preclinical data support this concern, systematic clinical evidence remains limited, highlighting the need for prospective studies with longitudinal sexual function endpoints. In this context, clinicians should proactively assess sexual function before and during GLP-1 therapy using validated instruments and integrate sexual health into comprehensive obesity care for midlife women.
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- Premature menopause is associated with the development of high blood pressure: a UK Biobank cohort study. [Journal Article]Menopause. 2026 Jul 28. [Online ahead of print]M
- CONCLUSIONS: Premature menopause had a significant effect on the development of hypertension during follow-up. Surgical menopause did not have a significant, independent effect.
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- Translation, cross-cultural adaptation, and validation of the Thai version of the Hot Flash-related Daily Interference Scale (Thai HFRDIS). [Journal Article]Menopause. 2026 Jul 28. [Online ahead of print]M
- CONCLUSIONS: The Thai Hot Flash-related Daily Interference Scale demonstrated reliability and validity and provides a brief measure of vasomotor symptom-related interference for Thai-speaking women in clinical practice and research.
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- The integration of migraine and sleep disturbance in perimenopause: a narrative review. [Journal Article]Menopause. 2026 Jul 28. [Online ahead of print]M
- CONCLUSIONS: An integrated approach to assessment and monitoring of migraine and sleep disorders during perimenopause, and treatment considerations impacting both conditions can reduce the burden of migraine and improve sleep. Coordination of treatment across both has the potential to improve quality of life of women in perimenopause. Further research is needed to better understand coordinated approaches to this complex interplay.
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- Modeling cardiovascular risk across the menopause transition: a synthetic cohort study. [Journal Article]Menopause. 2026 Jul 28. [Online ahead of print]M
- CONCLUSIONS: This synthetic cohort provides a transparent framework for simulating menopause-related cardiovascular risk trajectories and prevention scenarios.
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- Psychological symptoms during perimenopause: a global perspective. [Journal Article]Menopause. 2026 Jul 28. [Online ahead of print]M
- CONCLUSIONS: Significantly greater psychological symptom burden was identified in the perimenopause group compared with the premenopause group, with the greatest difference noted for the individual symptom of exhaustion. Differences in symptom burden were also identified by country.
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- Dietary supplements for menopausal symptoms and health: a bibliometric analysis of US research (2000-2024). [Journal Article]Menopause. 2026 Jul 28. [Online ahead of print]M
- CONCLUSIONS: Dietary supplement research during the menopause transition has remained limited over the last two decades, with perimenopause notably underrepresented. The large number of distinct ingredients, coupled with limited collaborations among researchers, suggests dispersed research efforts and few replication studies. The imbalance between the number of ingredients studied and supporting studies may hinder the development of evidence-based guidance, but also presents an opportunity to harmonize research efforts and produce stronger science.
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- Cardiorespiratory fitness, physical activity, and vasomotor symptoms of menopause. [Journal Article]Menopause. 2026 Jul 28. [Online ahead of print]M
- CONCLUSIONS: Fitness and MVPA in young or mid-adulthood were not independently associated with severe VMS. Other mitigation strategies seem necessary.
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