- Time trends in stroke incidence and modifiable risk factor prevalence in England (2018-2024): A record linkage population-based study. [Journal Article]PLoS Med. 2026 Aug 07; 23(8):e1004999. [Online ahead of print]PM
- CONCLUSIONS: There was an increase in stroke incidence at younger ages, with no increase at older ages, especially for ethnic minority groups, during and after the COVID-19 pandemic. This coincided with worsening in risk factor identification and diagnosis in primary care, highlighting missed opportunities that need to be urgently addressed.
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- Surgical palliative care: A multidisciplinary perspective on where we stand and how we need to evolve. [Journal Article]PLoS Med. 2026 Aug; 23(8):e1005188.PM
- Surgical palliative care (SPC) integrates the principles of symptom-based care and relief of suffering into traditional surgical practice. From the perspectives of a bedside nurse, surgical critical care fellow, and surgical oncologist, there are natural opportunities to incorporate these principles and in doing so, progress towards SPC becoming the standard of practice.
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- Cost-effectiveness of pirfenidone for patients with cancer and grade 2 or grade 3 radiation-induced lung injury: A modeling study. [Journal Article]PLoS Med. 2026 Aug; 23(8):e1004817.PM
- CONCLUSIONS: For grade 2 or 3 RILI, pirfenidone plus glucocorticoids is cost-effective compared with glucocorticoids alone. This strategy offers a practical and evidence-based option for RILI clinical management.
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- Adherence to medications, lifestyle advice, and self-monitoring for type 2 diabetes and hypertension in sub-Saharan Africa: A systematic review, meta-analysis, and interactive network analysis. [Journal Article]PLoS Med. 2026 Aug 03; 23(8):e1005189. [Online ahead of print]PM
- CONCLUSIONS: Adherence across treatment pillars is suboptimal. Education, self-efficacy, and social support represent priority candidates for future interventional studies aimed at improving adherence. The review was registered with PROSPERO (CRD42024626793).
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- Trajectories of physical function, depressive symptoms, and cognitive performance before and after falls in older adults: A matched multicohort study. [Journal Article]PLoS Med. 2026 Aug; 23(8):e1005083.PM
- CONCLUSIONS: In older adults, multidomain functional decline appears to precede falls by several years and worsens further after fall events. Falls may therefore signal broader functional deterioration and highlight the need for prevention and management strategies addressing physical, psychological, and cognitive domains.
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- Expanding the Developmental Origins of Health and Disease beyond maternal behaviors. [Journal Article]PLoS Med. 2026 Jul; 23(7):e1005208.PM
- Developmental Origins of Health and Disease (DOHaD) research has long emphasized maternal pregnancy behaviors as key determinants of child health. New evidence recently published in PLOS Medicine suggests the greatest opportunities to improve child health may lie in tackling socioeconomic disadvantage rather than maternal behavior alone.
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- Maternal congenital heart disease: Implications for the next generation. [Review]PLoS Med. 2026 Jul; 23(7):e1005191.PM
- Advances in medical and surgical treatment of congenital heart disease (CHD) now allows most affected individuals to reach adulthood and parenthood. While maternal CHD is associated with pregnancy complications, emerging evidence suggests a possible increased risk of developmental challenges in offspring, particularly among children of mothers with severe CHD.
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- The cancer survivorship paradox in the digital era. [Journal Article]PLoS Med. 2026 Jul; 23(7):e1005174.PM
- Many assumptions around patient needs and support guide current oncology practice and cancer survivorship care in the digital era. Addressing these assumptions and providing smarter, holistic, tech-enabled follow-up models are essential for truly effective and sustainable person-centered care.
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- Exploring parental prenatal influences on child health: A multicohort study and data visualisation tool. [Journal Article]PLoS Med. 2026 Jul; 23(7):e1005153.PM
- CONCLUSIONS: Our findings suggest that wider familial socioeconomic conditions may be a more important determinant of child health than specific parental health behaviours prenatally. Interventions to improve population health may be most effective if they target wider social inequalities, rather than individual behaviours and mothers specifically. We encourage researchers to use EPoCH Explorer to prioritise associations for exploration in their own datasets, thus enabling replication and cross-context comparison to validate and extend the generalisability of our findings.
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- Whose fears count? Legitimacy, trust and viral outbreak responses after COVID-19. [Editorial]PLoS Med. 2026 Jul; 23(7):e1005184.PM
- COVID-19 transformed viral outbreak response from a predominantly public health challenge into a political and security concern. Recent responses to Ebola, mpox, and other emerging infections suggest that preparedness is increasingly shaped by whose fears are prioritized in decision-making. The challenge is ensuring that competing perceptions of risk are managed in ways that are perceived as legi…
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- Optimising scale-up of injectable lenacapavir for HIV pre-exposure prophylaxis in South Africa: A modelling study and economic evaluation. [Journal Article]PLoS Med. 2026 Jul; 23(7):e1004882.PM
- CONCLUSIONS: Delivering LEN to persons with elevated HIV risk in South Africa is more cost-effective than existing oral PrEP and can speed up HIV incidence reduction. Prioritising uptake among groups at highest risk is essential to maximise impact and cost-effectiveness.
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- Adverse pregnancy outcomes and long-term risk of peripheral artery disease: A cohort study. [Journal Article]PLoS Med. 2026 Jul; 23(7):e1004821.PM
- CONCLUSIONS: In this large national cohort, all adverse pregnancy outcomes were associated with increased risk for PAD up to 46 years later. Women with adverse pregnancy outcomes need early preventive actions and long-term clinical follow-up to reduce their risk of PAD and other associated cardiovascular diseases.
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- Brain aging patterns among nine neurological disorders: A case-control study. [Journal Article]PLoS Med. 2026 Jul; 23(7):e1004860.PM
- CONCLUSIONS: In summary, the different brain aging patterns, each based around specific underlying circuits, may serve as neuroimaging biomarkers for understanding the neural aging mechanisms in commonly occurring brain disorders. Future studies should test whether these disorder-specific brain aging patterns can serve as useful biomarkers to guide critical clinical decision-making.
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- Assessing spatial transmission risk of respiratory infectious diseases across cities of different socioeconomic tiers in China: A modelling study. [Journal Article]PLoS Med. 2026 Jul; 23(7):e1005172.PM
- CONCLUSIONS: Spatial transmission risk reflects an interaction between pathogen-specific transmissibility and the hierarchical organisation of China's urban mobility system. These findings indicate that surveillance and response strategies effective for less transmissible pathogens may be insufficient for highly transmissible variants. Mobility-informed, tier-specific risk assessment may help inform early warning and support more adaptive public health responses. Because the framework relies on routinely available mobility data and minimal pathogen-specific inputs, it may provide a scalable approach for epidemic preparedness, including potential future emerging respiratory threats (Disease X).
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- Progress and promise of CAR-T cell treatment in autoimmune diseases. [Review]PLoS Med. 2026 Jul; 23(7):e1005179.PM
- Chimeric antigen receptor (CAR)-expressing cells bear a great potential for the treatment of autoimmune diseases. While numerous challenges persist, recent technological developments have demonstrated the potential for CAR cells to reset dysfunctional immune systems and transform care for patients with autoimmune disease.
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