- Assessment of the efficacy and medication adherence of fluticasone propionate-salmeterol combination delivered via a capsule-based dry powder inhaler in asthmatic patients. [Journal Article]Allergol Immunopathol (Madr). 2026; 54(4):114-119.AI
- CONCLUSIONS: This study demonstrates that fluticasone-salmeterol capsule inhaler therapy can significantly improve symptom control and respiratory function in adult asthma patients.
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- In Vitro Performance of Valved Holding Chambers in Paediatric Asthma Controller Therapy. [Journal Article]Acta Paediatr. 2026 Jun 02. [Online ahead of print]AP
- CONCLUSIONS: There were notable differences between the tested VHC's drug delivery. Ciclesonide exhibited favourable aerodynamic properties than fluticasone.
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- Drugs and Lactation Database (LactMed®): Fluticasone, Inhaled [BOOK]Drugs and Lactation Database (LactMed®). National Institute of Child Health and Human Development: Bethesda (MD).BOOK
- Although not measured, the amounts of inhaled corticosteroids absorbed into the maternal bloodstream and excreted into breastmilk are probably too small to affect a breastfed infant. Expert opinion considers inhaled, nasal and oral corticosteroids acceptable to use during breastfeeding.[1,2] See also Fluticasone, Topical.
- Fluticasone- vs Budesonide-Based Dual Therapy for COPD. [Journal Article]JAMA Netw Open. 2026 Mar 02; 9(3):e260959.JN
- CONCLUSIONS: In this cohort study of new ICS-LABA users with COPD, once-daily dry powder fluticasone furoate-vilanterol inhalers were associated with slightly improved clinical outcomes compared with twice-daily metered-dose budesonide-formoterol inhalers and twice-daily dry powder fluticasone propionate-salmeterol inhalers. Further studies are needed to explore potential intraclass differences among inhalers used to treat COPD.
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- PrecISE-a biomarker-stratified adaptive trial of 5 interventions in severe asthma: Final protocol and the baseline cohort. [Randomized Controlled Trial]
- CONCLUSIONS: The PrecISE adaptive study design with multiperiod crossovers is an efficient and novel way to study multiple interventions simultaneously in a heterogeneous disease such as asthma.
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- Economic evaluation of single-inhaler triple therapy for chronic obstructive pulmonary disease in Thailand. [Journal Article]BMJ Open Respir Res. 2026 Feb 12; 13(1).BO
- CONCLUSIONS: Our study indicated that SITTs are not cost-effective at the current price compared with the current MITT for COPD treatment. However, FF/UMEC/VI could be a promising option, with an approximately 30% price reduction.
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- Disproportionate increase in COPD exacerbation risk for 3 months after discontinuing LAMA or ICS: insights from the FLAME trial. [Randomized Controlled Trial]Thorax. 2026 May 14; 81(6):533-540.T
- CONCLUSIONS: Our findings suggest potent LAMA and ICS treatment withdrawal effects on exacerbations, highlighting the importance of treatment adherence and accounting for withdrawal effects in clinical trials.
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- Relative Bioavailability of Inhaled Fluticasone Propionate and Salmeterol - is Population Pharmacokinetic Modelling a Relevant Alternative to a Non-Compartmental Approach? [Randomized Controlled Trial]
- CONCLUSIONS: Model- and NCA-based approaches to assess bioequivalence were consistent. However, a frequentist parametric approach that fully utilizes the population analysis potential and mechanistically predicts regional pulmonary deposition of FP and SALM would require a demographically more heterogenous data set and analysis including additional outcomes of parenteral and oral administration to discriminate presystemic from systemic disposition.
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- Is dual bronchodilation a cost-effective alternative to ICS/LABA in COPD? A Colombian healthcare system evaluation. [Journal Article]Expert Rev Respir Med. 2026 Apr; 20(4):447-455.ER
- CONCLUSIONS: UMEC/VI is a highly cost-effective alternative to FSC for moderate to severe COPD in Colombia, offering improved clinical outcomes and economic value for resource-constrained health systems.
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- Comparative effectiveness of fixed-dose inhaled corticosteroid/long-acting beta-agonist therapy in adult patients with asthma. [Journal Article]Ann Allergy Asthma Immunol. 2026 Jan; 136(1):75-84.e10.AA
- CONCLUSIONS: The findings suggest that fluticasone furoate/vilanterol may offer a potential advantage for asthma management compared with other fixed-dose ICS/LABA combinations.
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- The effect of different inhaled corticosteroid and long-acting bronchodilator combinations on the airway microbiome in patients with severe COPD: a randomised trial (MUSIC). [Randomized Controlled Trial]
- CONCLUSIONS: FS500 increased sputum but not upper airway bacterial loads. ICS withdrawal was poorly tolerated in severe COPD.
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- Cost-Utility of Fluticasone Propionate/Salmeterol and Fluticasone Propionate Monotherapy in Step-Up Treatment of Childhood Asthma. [Journal Article]Pediatr Pulmonol. 2025 Aug; 60(8):e71244.PP
- CONCLUSIONS: This study's findings are aligned with previous evidence on the economic value of ICS/LABA combinations, which found similar cost-effectiveness ratios for ICS/LABA therapies within accepted thresholds. Our probabilistic perspective supports FSC's potential as a feasible option in clinical practice for achieving better asthma control in children.
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- Budesonide-Formoterol Metered-Dose Inhaler vs Fluticasone-Salmeterol Dry-Powder Inhaler. [Journal Article]
- CONCLUSIONS: The study found that the VHA formulary transition from budesonide-formoterol metered-dose inhaler to fluticasone-salmeterol dry-powder inhaler was associated with increased health care utilization, suggesting potential harm and the need to reevaluate this policy change.
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- Comparative effectiveness of inhaled fluticasone propionate/salmeterol and budesonide/formoterol fixed-dose combinations in asthma control - a retrospective United States database analysis. [Journal Article]
- CONCLUSIONS: FP/SAL and BUD/FOR were similarly effective for asthma control in real-world settings, while FP/SAL was generally associated with greater medication adherence, a key factor for long-term control.
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- The comparative effectiveness and safety of fluticasone-salmeterol via metered-dose versus dry powder inhalers for COPD: A new user cohort study. [Journal Article]
- CONCLUSIONS: In this cohort study comparing two brand-name fluticasone-salmeterol inhalers prescribed for COPD in routine clinical practice, effectiveness and safety outcomes were similar for patients receiving metered-dose and dry powder versions.
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