- Phenotypic Effects of a Novel HCN4 c.1494C>A (p.Ser498Arg) Sequence Variation. [Case Reports]JACC Case Rep. 2026 Jun 02; :108570. [Online ahead of print]JC
- CONCLUSIONS: We characterize the phenotypic effects of a novel SV in HCN4 c.1494C>A (p.Ser498Arg), which include SND, AF, and LVNC. Given their rarity, HCN4 mutations are poorly characterized, particularly in children. Our findings highlight the importance of further systemic studies to address significant gaps in genotype-phenotype correlation.Loss-of-function HCN4 variants cause diverse phenotypes. We describe a novel pathogenic HCN4 SV c.1494C>A (p.Ser498Arg) causing overlapping SND, AF, and LVNC phenotype in a multigenerational cohort.
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- Dexmedetomidine Dosing Strategies in Sedation and Anesthesia: Pharmacokinetics, Safety, and Clinical Applications - A Narrative Review. [Review]Drug Des Devel Ther. 2026; 20:606156.DD
- CONCLUSIONS: The available evidence suggests that dexmedetomidine offers a generally favorable safety profile across sedation and anesthesia contexts. However, conclusions are limited by dosing heterogeneity, small sample sizes, inconsistent outcome definitions, and absent long-term safety data. Standardized multicenter trials with uniform outcome criteria are needed to establish definitive dosing recommendations.
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- Acute Management of Dysrhythmias. [Review]Tech Vasc Interv Radiol. 2026 Jun; 29(2):101110.TV
- Vascular Interventional Radiologists (VIRs) frequently care for patients with high severity of illness, multiple comorbidities, and physiologic derangements. The incidence and prevalence of abnormal cardiac rhythms (dysrhythmias) in these patients is high, and these can quickly lead to hemodynamic instability, shock, and death. Therefore, VIRs should be skilled in the evaluation and management of…
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- Perineural dexmedetomidine decreases the onset time of bupivacaine 0.5%-epinephrine-dexamethasone for infraclavicular block: a randomized trial. [Journal Article]Reg Anesth Pain Med. 2026 Jun 02. [Online ahead of print]RA
- CONCLUSIONS: Compared with control (dexmedetomidine 0 µg/kg), perineural dexmedetomidine 0.67 µg/kg and 1.33 µg/kg decrease the onset time of bupivacaine 0.5%-epinephrine (5 µg/mL)-perineural dexamethasone (4 mg) for US-guided ICBs. Although no intergroup differences in onset were found between the 0.67 µg/kg and 1.33 µg/kg doses, there was a statistically significant directional trend, which suggested a possible dose-dependent effect. Future trials are also required to determine the optimal dose of perineural dexmedetomidine.
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- Sugammadex Versus Neostigmine: A Comparative Study of Efficacy and Safety in the Cath Lab. [Journal Article]Cureus. 2026 Apr; 18(4):e108066.C
- Background Effective and complete reversal of neuromuscular blockade is essential for safe recovery from general anesthesia. This becomes more significant in patients undergoing cardiac procedures as they have limited cardiopulmonary reserve and reduced tolerance for physiological instability. Neostigmine is the conventional agent of choice for the reversal of non-depolarizing neuromuscular block…
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- Effects of different sedation regimens on delirium in ICU patients. [Journal Article]Front Neurol. 2026; 17:1745283.FN
- CONCLUSIONS: In this prospective cohort, dexmedetomidine-predominant sedation was associated with a lower risk of post-landmark delirium and better sedation quality than midazolam, at the cost of more bradycardia and without differences in mortality. These findings warrant multicenter confirmation and randomized evaluation.
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- Case Report: Sedation crisis caused by drug-induced sleep endoscopy in a pediatric patient with symptomatic multilevel airway obstruction. [Case Reports]Front Pediatr. 2026; 14:1825319.FP
- CONCLUSIONS: This case highlights that multilevel airway obstruction is a critical mechanism of pediatric sedation crisis. The upper airway anatomical narrowing and central airway dynamic collapse synergistically worsened under sedation. Occult tracheomalacia should be considered for sedation-related events of unclear etiology. DISE can aid in systematic airway assessment to achieve precise diagnosis, risk stratification, and safe pediatric sedation management.
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- Methylprednisolone-Induced Delayed and Sustained Bradycardia in Multisystem Inflammatory Syndrome in Children. [Journal Article]Cureus. 2026 Apr; 18(4):e107919.C
- CONCLUSIONS: A high proportion of delayed and sustained bradycardia in children with MIS-C, irrespective of age, dose of methylprednisolone, or presence of shock, which is possibly induced by the steroid, was observed. The time to onset and the time to recovery were independent of the above factors. However, the heart rate at bradycardia varied significantly by dose and by the presence of shock.
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- Anesthesia management in oncology patients undergoing irreversible electroporation outside the operating room: a case series. [Journal Article]BMC Anesthesiol. 2026 Jun 01. [Online ahead of print]BA
- CONCLUSIONS: Irreversible electroporation appears to be a feasible and potentially safe procedure when appropriate anesthetic precautions are applied. Deep neuromuscular blockade, electrocardiography synchronization, and readiness for arrhythmia management are essential for patient safety. Multidisciplinary coordination and postoperative follow-up further enhance procedural success.
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- Perioperative dexmedetomidine is associated with improved respiratory outcomes in patients undergoing cardiac surgery: a systematic review and meta-analysis of randomized controlled trials. [Systematic Review]BMC Anesthesiol. 2026 Jun 01. [Online ahead of print]BA
- CONCLUSIONS: Perioperative dexmedetomidine may be associated with improved respiratory outcomes in cardiac surgery patients. However, the evidence for reduction in overall PPCs remains limited, and dexmedetomidine may increase the risk of bradycardia. Larger, high-quality RCTs are needed to confirm its safety and benefits.
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- Long-Term Sedation Effect of Cipepofol Compared to Dexmedetomidine in Patients Receiving Invasive Mechanical Ventilation: A Multicenter, Randomized, Open-Label, Parallel-Controlled Study. [Journal Article]
- CONCLUSIONS: Cipepofol is a safe and effective alternative sedative for long-term sedation (≥ 24 h) of Chinese ICU patients receiving MV, providing sedation performance comparable to dexmedetomidine, with some potential advantages in terms of stability and less need for rescue therapy.
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- Comparative In Vitro Release Profiling of Brand and Generic Metoprolol Extended-Release Formulations in the Context of Product Switching. [Journal Article]Pharmazie. 2026 May 19; 81(5):51859.P
- CONCLUSIONS: The results underscore the importance of considering patient-specific variability when switching from branded to generic formulations. Incorporating physiologically relevant in vitro studies combined with physiologically based pharmacokinetic and pharmacodynamic modeling in future research may improve predictions of in vivo performance and support safer therapeutic decisions.
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- From profound hypothermia to malignant hyperpyrexia: a case report of biphasic thermoregulatory crisis following acute high cervical spinal cord injury. [Journal Article]BMC Neurol. 2026 May 29. [Online ahead of print]BN
- CONCLUSIONS: This case illustrates the biphasic and rapidly progressive nature of autonomic thermoregulatory dysfunction in acute high cervical SCI. Neurogenic fever, though uncommon, may occur within hours and is associated with high morbidity and mortality. Continuous temperature monitoring, early hemodynamic stabilization, and high clinical suspicion are critical, particularly in resource-limited settings.
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- A Call for Vigilance: Trigeminocardiac Reflex Presenting As Ventricular Bigeminy During Marginal Mandibulectomy. [Case Reports]Cureus. 2026 Apr; 18(4):e107789.C
- The trigeminocardiac reflex (TCR) is an autonomic reflex elicited by stimulation of the trigeminal nerve and is most commonly characterized by bradycardia and hypotension. In oral and maxillofacial surgery, peripheral TCR may occur during manipulation of the maxillary or mandibular divisions, occasionally presenting with atypical cardiovascular responses. We report a rare case of peripheral TCR m…
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- Feasibility of a Modified Wake-Up Test Without Intraoperative Neurophysiological Monitoring in Scoliosis Surgery: A Case Series. [Journal Article]Case Rep Anesthesiol. 2026; 2026:8811380.CR
- The wake-up test (WKT) is an important intraoperative method for assessing spinal cord function during scoliosis surgery, particularly in settings where intraoperative neurophysiological monitoring (IONM) is unavailable. This short case series describes seven patients undergoing scoliosis surgery with a modified wake-up test (mWKT). Sugammadex was used to reverse neuromuscular blockade to facilit…
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