(Bradycardia)
33,121 results
  • Phenotypic Effects of a Novel HCN4 c.1494C>A (p.Ser498Arg) Sequence Variation. [Case Reports]
    JACC Case Rep. 2026 Jun 02; :108570. [Online ahead of print]Meena H, Kohli U, Natarajan RJC
  • CONCLUSIONS: We characterize the phenotypic effects of a novel SV in HCN4 c.1494C>A (p.Ser498Arg), which include SND, AF, and LVNC. Given their rarity, HCN4 mutations are poorly characterized, particularly in children. Our findings highlight the importance of further systemic studies to address significant gaps in genotype-phenotype correlation.Loss-of-function HCN4 variants cause diverse phenotypes. We describe a novel pathogenic HCN4 SV c.1494C>A (p.Ser498Arg) causing overlapping SND, AF, and LVNC phenotype in a multigenerational cohort.
  • Acute Management of Dysrhythmias. [Review]
    Tech Vasc Interv Radiol. 2026 Jun; 29(2):101110.Desai KMTV
  • Vascular Interventional Radiologists (VIRs) frequently care for patients with high severity of illness, multiple comorbidities, and physiologic derangements. The incidence and prevalence of abnormal cardiac rhythms (dysrhythmias) in these patients is high, and these can quickly lead to hemodynamic instability, shock, and death. Therefore, VIRs should be skilled in the evaluation and management of…
  • Perineural dexmedetomidine decreases the onset time of bupivacaine 0.5%-epinephrine-dexamethasone for infraclavicular block: a randomized trial. [Journal Article]
    Reg Anesth Pain Med. 2026 Jun 02. [Online ahead of print]Samerchua A, Supphapipat K, … Tran QRA
  • CONCLUSIONS: Compared with control (dexmedetomidine 0 µg/kg), perineural dexmedetomidine 0.67 µg/kg and 1.33 µg/kg decrease the onset time of bupivacaine 0.5%-epinephrine (5 µg/mL)-perineural dexamethasone (4 mg) for US-guided ICBs. Although no intergroup differences in onset were found between the 0.67 µg/kg and 1.33 µg/kg doses, there was a statistically significant directional trend, which suggested a possible dose-dependent effect. Future trials are also required to determine the optimal dose of perineural dexmedetomidine.
  • Sugammadex Versus Neostigmine: A Comparative Study of Efficacy and Safety in the Cath Lab. [Journal Article]
    Cureus. 2026 Apr; 18(4):e108066.Prabhakaran P, Umbarkar S, … Dixit PC
  • Background Effective and complete reversal of neuromuscular blockade is essential for safe recovery from general anesthesia. This becomes more significant in patients undergoing cardiac procedures as they have limited cardiopulmonary reserve and reduced tolerance for physiological instability. Neostigmine is the conventional agent of choice for the reversal of non-depolarizing neuromuscular block…
  • Effects of different sedation regimens on delirium in ICU patients. [Journal Article]
    Front Neurol. 2026; 17:1745283.Liu F, Yao J, … Li FFN
  • CONCLUSIONS: In this prospective cohort, dexmedetomidine-predominant sedation was associated with a lower risk of post-landmark delirium and better sedation quality than midazolam, at the cost of more bradycardia and without differences in mortality. These findings warrant multicenter confirmation and randomized evaluation.