Congenital hemangioma with thrombocytopenia is rare and is often mistaken for Kasabach-Merritt phenomenon seen in kaposiform hemangioendothelioma. We present three neonatal cases with severe but transient thrombocytopenia that resolved without intervention. Accurate diagnosis, cardiac evaluation, and cautious management are essential, as most patients recover spontaneously, avoiding unnecessary interventions.

Cardiac papillary fibroelastoma (PFE) is rare in children, and large (>30 mm), mobile, right-sided PFEs are exceptionally uncommon. This report describes a 7-year-and-6-month-old patient who presented with upper respiratory tract infection and an incidental cardiac murmur. Transthoracic echocardiography revealed a 30 × 25 × 21 mm pedunculated, mobile mass on the anterior tricuspid valve leaflet. Differential diagnosis included thrombus, vegetation, and other cardiac tumors. Surgical excision with tricuspid valvuloplasty was performed due to embolization risk. Gross examination showed a cauliflower-like mass. The patient recovered uneventfully with preserved valve function. This case demonstrates that large, mobile right-sided PFEs can occur in asymptomatic children, and early surgical intervention with valve preservation is recommended to prevent embolic complications.

Patients with myeloproliferative neoplasms (MPNs), including essential thrombocythemia, polycythemia vera, and myelofibrosis, are at increased risk of cardiovascular disease and complications. The most recognized cardiovascular complications among patients with MPN are arterial and venous thrombotic events. However, mounting evidence suggest that nonthrombotic cardiovascular complications, including heart failure and pulmonary hypertension, are also common and are associated with adverse outcomes and overall prognosis. Therefore, it is important that hematologists become aware of such complications and are able to identify them as they arise. Additionally, cardiovascular disease treatment, including antithrombotic therapy and guideline-directed medical therapy for heart failure, may impact MPN-specific outcomes. Therefore, we review current literature of cardiovascular disease and complications among patients with MPNs and their impact on patient outcomes and prognosis.

Tumor-derived extracellular vesicles (EVs) contribute to tumor progression and metastasis. We recently reported that EVs derived from normal kidney tissues (N-EVs) suppress sterile cardiac inflammation in myocardial ischemic injury models. However, whether N-EVs affect the progression of renal cancer remains elusive. In the present study, we demonstrated that N-EVs inhibit the proliferation and invasion of clear cell renal cell carcinoma (ccRCC) in vitro. When administered intravenously, N-EVs were mainly retained within the tumors and suppressed ccRCC progression in cancer-bearing murine models. Further miRNA sequencing revealed that the target genes of the top 20 miRNAs in N-EVs were primarily enriched in signaling pathways, including the MAPK and Ras pathways. Moreover, N-EVs treatment modulated the tumor microenvironment and inhibited cancer cell proliferation and angiogenesis through the transfer of their inhibitory miRNAs. Therefore, manipulating normal tissue-derived EVs (including those from cultured kidney organoids) or their miRNA cargo may represent a promising potential strategy for treating ccRCC in clinical settings.