- Clonidine in the Management of Delirium in Hospitalized Patients: A Retrospective Chart Review. [Letter]J Acad Consult Liaison Psychiatry. 2026 Aug 18. [Online ahead of print]JA
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- Benzodiazepine Prescribing in Delirium Diagnosis: National Data on Clinical Practice. [Journal Article]J Acad Consult Liaison Psychiatry. 2026 Aug 18. [Online ahead of print]JA
- CONCLUSIONS: Benzodiazepines are frequently prescribed around the time of delirium diagnoses across diverse inpatient settings. Overall, the data highlight a discrepancy between guidelines discouraging benzodiazepines and actual clinical practice. The data suggest the need for further research that may identify clinical approaches to enhance adherence to delirium management guidelines.
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- A Systematic Review of the Effectiveness of Delirium Recovery Interventions. [Review]J Am Med Dir Assoc. 2026 Aug 18; 27(10):106420. [Online ahead of print]JA
- CONCLUSIONS: Current evidence on delirium recovery interventions is limited, heterogeneous, and largely confined to the acute care setting. Emotional recovery and long-term outcomes remain underexplored. There is an urgent need for studies evaluating multidisciplinary interventions that address physical, cognitive, and emotional recovery after delirium.
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- Neurocognitive outcomes in survivors of severe burn injuries: A systematic review. [Review]Burns. 2026 Jul 23; 52(9):108155. [Online ahead of print]B
- CONCLUSIONS: Survivors of severe burn injuries are at substantial risk for both acute and chronic neurocognitive impairments. Routine cognitive screening and multidisciplinary rehabilitation should be integral to post-burn care. Future research should employ standardized neurocognitive batteries, control for confounding factors, and include long-term follow-up to clarify the trajectory of recovery.
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- Transcranial Electrical Stimulation and Delirium Among Postoperative Patients: A Randomized Clinical Trial. [Randomized Controlled Trial]JAMA Netw Open. 2026 Aug 03; 9(8):e2628284.JN
- CONCLUSIONS: In this randomized clinical trial of tES for POD, there was no evidence for a uniform effect of postoperative tES on the incidence of POD, but it suggested a benefit of parietal α oscillatory enhancement for patients with longer surgery. Future research has to test the specific effect on vulnerable groups, examine the optimal timing for tES application to modulate POD, and investigate the value of personalizing tES parameters.
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- Identification of Risk Factors for Postoperative Delirium and Targeted Preventive Strategies in Elderly Patients in the Emergency Surgical ICU. [Journal Article]Ann Ital Chir. 2026 Aug 13; 97(8):1517-1528.AI
- CONCLUSIONS: This study identified five key and modifiable risk factors for POD in elderly emergency surgical ICU patients and successfully developed and validated a high-performance nomogram prediction tool. This model aids in the early identification of high-risk patients, providing a basis for implementing targeted bundled prevention strategies, which holds promise for improving clinical outcomes in this vulnerable population.
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- Ciprofol versus Propofol for Emergence Agitation and Recovery Quality in Pediatric Dental Anesthesia: A Randomized Controlled Trial. [Randomized Controlled Trial]Drug Des Devel Ther. 2026; 20:624658.DD
- CONCLUSIONS: While the incidence of emergence agitation did not differ significantly between groups, ciprofol was associated with significantly lower PAED scores, indicating reduced EA severity, along with faster emergence, improved recovery quality and higher parental satisfaction compared with propofol. These findings suggest that ciprofol may be an effective alternative to propofol in pediatric outpatient dental anesthesia, though the lack of a statistically significant difference in the primary outcome warrants cautious interpretation.
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- Mechanism-informed diagnostic accuracy of blood biomarkers for sepsis-associated encephalopathy: a systematic review and Bayesian diagnostic network meta-analysis. [Systematic Review]Front Mol Neurosci. 2026; 19:1789013.FM
- CONCLUSIONS: Blood biomarkers for SAE exhibit a biologically coherent immune-to-neuronal cascade, and their diagnostic performance appears sensitive to phenotyping and anchor-based sampling context. These findings are hypothesis-generating and support prospective head-to-head validation to determine whether mechanism-staged biomarker panels add incremental diagnostic value beyond established clinical predictors under standardized phenotyping and anchor-based sampling protocols.
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- Delirium superimposed on dementia in nursing homes: prevalence, incidence, and prognosis - protocol of a prospective multicenter cohort study. [Multicenter Study]BMC Geriatr. 2026 Aug 15; 26(1).BG
- CONCLUSIONS: Findings will inform development of context-sensitive prevention and management strategies to strengthen evidence-based delirium care in nursing homes.
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- Frailty Assessment in Coronary Artery Bypass Grafting: A Review of Current Tools and Clinical Applications. [Review]J Cardiothorac Vasc Anesth. 2026 Jul 22. [Online ahead of print]JC
- Frailty has emerged as a critical determinant of operative risk among patients undergoing coronary artery bypass grafting (CABG), particularly as the age and comorbidity burden of this population continue to rise. Unlike chronological age or traditional risk indices alone, frailty captures reduced physiologic reserve and vulnerability to surgical stress through phenotypic, functional, and cumulat…
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- Comment on "Using the ascertain dementia eight-item questionnaire to identify at-risk older surgical patients". [Letter]J Clin Anesth. 2026 Aug 17; 114:112293. [Online ahead of print]JC
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- Prebiotic raffinose attenuates surgery-induced delirium-like behaviors through gut microbiota-mediated serotonergic signaling in frail senescence-accelerated mice: an experimental study using SAMP10 mice. [Journal Article]
- CONCLUSIONS: Prebiotic raffinose attenuates surgery-induced systemic inflammation and preserves cognitive-attentional and motivational performance in frail mice, providing convergent behavioral, biochemical, and microbiome evidence consistent with a gut-microbiota-serotonergic mechanism, which requires direct causal validation in future studies. These findings provide a preclinical rationale for prehabilitation nutritional strategies targeting the gut-brain axis, while acknowledging that individual behavioral readouts differ in the strength of the surgery-induced control-vs-surgery contrast.
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- Clinical EEG In Modern Psychiatry: Diagnostics and Prediction. [Review]Clin EEG Neurosci. 2026 Aug 17; :15500594261471242. [Online ahead of print]CE
- Clinical electroencephalography (EEG) remains a central diagnostic tool in psychiatry. As a non-invasive, widely available and cost-effective method with high temporal resolution, EEG contributes to the detection of epileptiform activity, exclusion of organic brain dysfunction, assessment of delirium and encephalopathies, differential diagnosis of dementias, and monitoring of psychopharmacologica…
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- Early nurse-detected delirium is a marker of 6-month mortality risk after acute coronary syndrome: A Multicentre Prospective Cohort Study. [Journal Article]Eur J Cardiovasc Nurs. 2026 Aug 17. [Online ahead of print]EJ
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- Preoperative anxiety, sleep disturbances and postoperative delirium in cardiac surgery: A scoping review for nursing practice. [Review]J Perioper Pract. 2026 Aug 17; :17504589261473132. [Online ahead of print]JP
- Preoperative anxiety, sleep disturbances and postoperative delirium are common complications among patients undergoing cardiac surgery and are associated with adverse perioperative outcomes. This scoping review aimed to synthesise evidence on the relationship between these factors and identify implications for perianaesthesia nursing practice. A literature search was conducted in PubMed, Scopus a…
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