The objective was to assess feasibility, perioperative safety, and one-year outcomes for weight loss, resolution/remission of obesity related diseases, early and late morbidity of robot-assisted conversion from laparoscopic sleeve gastrectomy (LSG) to single anastomosis sleeve ileal bypass (SASI). A single-center analysis of robotic conversion SASI after LSG conducted from 2023 to 2025. Intra-operative details and early morbidity were described using Dindo-Clavien's classification. One-year outcomes were analyzed in patients who had reached the 12-months postoperative follow-up at the time of analysis. 51 patients (42 F/9 M, mean age: 46.3 ± 9.2yo), with a mean pre-operative BMI = 43.3 ± 7.8 kg/m[2] underwent SASI, either for recurrent weight gain (RWG: 68.6%) or suboptimal clinical response (SCR: 31.4%). Median time after LSG was 62.5 months (IQR: 66.5). Mean operative time was 112.4 ± 33.7 min and same day discharge was possible for 78.4% of patients. There were five emergency departement visits (9.8%) for minor complications (five Dindo-Clavien grade 1) and no major complications at 30 days postoperative. At 1-year postoperative, 76.5% of patients had available follow-up data. From the time of primary LSG, the %EWL and %TWL were 66.7 ± 22.2% and 34.2 ± 10.9%, respectively. Revisional surgery was required for two patients with refractory gastroesophageal reflux disease (GERD: 3.9%). In our high-volume center, robotic conversion SASI after LSG offers a feasible and safe approach with acceptable one-year postoperative outcomes, whether for RWG or SCR, with low morbidity.

Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2 blockers) are routinely prescribed for the long-term management of chronic acid-related gastrointestinal conditions. Although prior research has explored a potential link between PPI exposure and cognitive decline, findings across studies have been inconsistent, and most investigations have concentrated on elderly populations.

Gastroesophageal reflux disease (GERD) is a common chronic disease of the gastrointestinal tract and is a problem in developed countries. In particular, clinicians are interested in the extraesophageal manifestations of this disease, and recently, dentists have been studying the erosion of hard dental tissues. This article provides a literature review of scientific papers published over the past 8 years that provide evidence-based experimental and clinical data on the most recent issues related to the prevention of hard dental tissue erosion in patients with gastroesophageal reflux disease. The meta-analysis used the resources of the eLibrary search engines, the PubMed website, and the data from the disserCat dissertation abstracts. The purpose of the study was to comprehensively examine the prevention of erosive lesions of hard dental tissues in patients with GERD. It was important to consider this issue from a preventive perspective, as it is often overlooked.

Cornelia de Lange syndrome (CdLS) encompasses a spectrum of findings from mild to severe. Severe (classic) CdLS is characterized by distinctive facial features, growth restriction (prenatal onset; <5th centile throughout life), hypertrichosis, and upper-limb reduction defects that range from subtle phalangeal abnormalities to oligodactyly (missing digits). Craniofacial features include synophrys, highly arched and/or thick eyebrows, long eyelashes, short nasal bridge with anteverted nares, small widely spaced teeth, and microcephaly. Individuals with a milder phenotype have less severe growth, cognitive, and limb involvement, but often have facial features consistent with CdLS. Across the CdLS spectrum IQ ranges from below 30 to 102 (mean: 53). Many individuals demonstrate autistic and self-destructive tendencies. Other frequent findings include cardiac septal defects, gastrointestinal dysfunction, hearing loss, myopia, and cryptorchidism or hypoplastic genitalia.