Endoscopic thoracic sympathectomy is an effective treatment of primary palmar hyperhidrosis. Currently, single-port thoracoscopy is the primary surgical approach. Ensuring efficacy and safety, reducing surgical obstacles, minimizing tissue damage, and enhancing cosmesis and aesthetics of the surgical incision are focal in clinical research on endoscopic thoracic sympathectomy. Herein, we report a simple and minimally invasive surgical technique that avoids collisions due to the telescope and endodissector crossing in single-port thoracoscopic surgery. This refers to the application of medical thoracoscopy combined with nonintubation anesthesia and perfusion index monitoring in the treatment of primary palmar hyperhidrosis.

Compensatory hyperhidrosis (CH) is a significant complication following surgery for primary hyperhidrosis, impairing patients' postoperative experience and quality of life. Radiofrequency sympathectomy (RFS) is one of the main minimally invasive surgeries for hyperhidrosis, yet high-risk factors and patient experiences of postoperative CH are rarely reported. This retrospective observational study (Strengthening the Reporting of Observational Studies in Epidemiology compliant) aimed to identify significant risk factors for CH after RFS and to develop a dynamic nomogram for individualized risk prediction. A total of 410 primary hyperhidrosis patients who underwent RFS between January 2018 and March 2023 were enrolled. A CH database was established via systematic follow-up to track postoperative sweating patterns. Detailed clinical assessments included the Numeric Rating Scale (NRS), Hyperhidrosis Disease Severity Scale (HDSS), and Hospital Anxiety and Depression Scale (HADS). Advanced statistical techniques, including logistic regression analysis, were used to identify potential risk factors for CH. Of the 410 patients, 281 (68.5%) developed CH, with 105 (25.6%) reporting moderate-to-severe symptoms. Multivariate analysis revealed 4 significant predictors of CH: male gender (odds ratio [OR] = 1.69); higher NRS scores (OR = 1.16); lower immediate postoperative HDSS (OR = 0.48); higher preoperative HADS scores (OR = 1.11). A dynamic, web-based nomogram was also developed to provide personalized CH risk prediction. Male gender, higher intraoperative NRS scores, lower immediate postoperative HDSS, and higher preoperative HADS scores were identified as independent risk factors. The constructed dynamic nomogram enables individualized risk prediction and supports clinicians in providing personalized preoperative counseling and perioperative management for patients undergoing RFS.

Pourfour du Petit syndrome (PdPS) is a rare oculosympathetic hyperactivity syndrome characterized by ipsilateral mydriasis, eyelid retraction, and hyperhidrosis. We report a case of a 36-year-old female who presented to the emergency department with a chief complaint of a dilated pupil with photosensitivity and blurred vision in the left eye (OS). On examination, the best corrected visual acuity was 20/20 in both eyes (OU). Anisocoria was observed with the right pupil measuring 4 mm in the dark and 2 mm in the light and the larger left pupil measuring 6 mm in the dark with minimal constriction in the light. There was no relative afferent pupillary defect (RAPD). Magnetic resonance angiography (MRA) and digital subtraction angiogram (DSA) of the head showed a 7 mm left paraclinoid ICA aneurysm. Neurovascular neurosurgery placed a flow diverting stent into the left ICA. Repeat DSA demonstrated near-complete resolution of the left ICA ophthalmic segment aneurysm status post-flow diversion. At the last follow-up one year later, the patient was stable clinically and radiographically with no further recurrences. Clinicians should be aware that anisocoria can be a potentially life-threatening presentation of intracranial vascular lesions.

Shapiro syndrome is a rare condition with fewer than 100 cases reported, initially characterized by the triad of hypothermia, hyperhidrosis, and agenesis of the corpus callosum. The diagnostic triad is no longer systematic, and the condition is now more broadly referred to as spontaneous periodic hypothermia. An 86-year-old patient presented with coma, hypothermia, and sweating. The differential diagnoses of hypothermia were ruled out and a diagnosis of a variant of Shapiro syndrome was made. Brain imaging revealed small corpus callosums. Treatment was symptomatic, with external warming and management of complications. The outcome was favorable, with cessation of hypothermia and gradual incomplete neurological recovery. This case highlights the importance of considering this syndrome when hypothermia and hyperhidrosis occur together. Elderly patients are at increased risk of serious complications and require appropriate management.

Topical glycopyrronium bromide is an acetylcholine receptor antagonist approved for the treatment of severe primary axillary hyperhidrosis in adults. The ointment is often prescribed off-label for hyperhidrosis on palms and soles. This case report presents ocular side effects after topical glycopyrronium bromide use, leading to several clinical follow-ups and diagnostic tests. This case report underscores the importance of recognising potential side effects for clinicians, especially in off-label treatment.