- Monoclonal gammopathy in ANCA-associated glomerulonephritis: prevalence, characteristics and outcomes. [Journal Article]Nephrol Dial Transplant. 2026 Aug 18. [Online ahead of print]ND
- CONCLUSIONS: MG is frequent in patients with ANCA-GN, mainly reflecting age and comorbidity but does not independently influence renal survival, mortality, or progression to hematological malignancy. MG should be considered a coexisting condition rather than a disease modifier in ANCA-GN, although standardized follow-up remains warranted.
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- Prediction and Progression Stratification of Type II Endoleak After EVAR Using Clinical, Anatomical, and Ultrasound Parameters. [Journal Article]J Endovasc Ther. 2026 Aug 18; :15266028261474361. [Online ahead of print]JE
- CONCLUSIONS: T2EL occurrence after EVAR was associated mainly with preoperative anatomy, collateral vessel conditions, and baseline patient factors, whereas sac progression in established T2EL appeared to be associated with exploratory ultrasound-derived hemodynamic and volumetric burden. These findings may help refine postoperative surveillance and selection for reintervention.Clinical ImpactType II endoleak after EVAR should not be managed as a uniform or inherently benign finding. In our cohort, T2EL occurrence was associated mainly with preoperative anatomy, collateral-vessel status, and baseline patient factors, whereas sac progression among established T2EL cases appeared to be associated with exploratory ultrasound-derived hemodynamic and volumetric burden. This 2-step framework may provide an exploratory strategy for postoperative risk stratification beyond simple endoleak detection and may help identify patients requiring intensified surveillance. However, because model development was based on limited T2EL events and ultrasound-derived measurements require broader external validation despite institutional diagnostic-performance and interobserver reliability assessments, clinical use remains premature.
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- Reply: Assessing the Risk of Kidney Stone Development in Patients With Idiopathic Intracranial Hypertension Treated With Carbonic Anhydrase Inhibitors. [Journal Article]J Neuroophthalmol. 2026 Sep 01; 46(3):444-445.JN
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- Comment: Assessing the Risk of Kidney Stone Development in Patients With Idiopathic Intracranial Hypertension Treated With Carbonic Anhydrase Inhibitors. [Journal Article]J Neuroophthalmol. 2026 Sep 01; 46(3):444.JN
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- Social Media Influencer Marketing as a Clinical Trial Recruitment Modality: Tutorial Informed by One Study's Approach. [Journal Article]J Med Internet Res. 2026 Aug 11; 28:e92813.JM
- CONCLUSIONS: Social media influencer marketing through Cameo Business is a rapid, low-cost mechanism for producing clinical trial recruitment videos and is feasible within typical trial timelines and budgets. To our knowledge, this is the first tutorial to document the procedure end to end, and it surfaces practical, ethical, and authenticity considerations, including governance of generative artificial intelligence and the limits of permissible video editing, that investigators should weigh before adopting this modality. The comparative effectiveness of influencer-based recruitment will be evaluated separately.
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- How Reliable and Reproducible Is Optical Coherence Tomography in Idiopathic Intracranial Hypertension? When Agreement Deteriorates in Advanced Papilledema. [Journal Article]J Neuroophthalmol. 2026 Aug 18. [Online ahead of print]JN
- CONCLUSIONS: In this exploratory study, automated OCT segmentation demonstrated substantial divergence from manually corrected pRNFL measurements in higher-grade papilledema, with discrepancies exceeding 150 µm in advanced disease. The reliability of manual correction decreased to moderate levels with increasing Frisén grade. These findings underscore the need to interpret OCT-derived pRNFL measurements cautiously and in conjunction with the clinical examination in higher-grade papilledema.
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- Regulatory Variant of Klotho (rs9563124) Associates with Ang-II Stimulated Aldosterone and Salt Sensitive Blood Pressure. [Journal Article]J Clin Endocrinol Metab. 2026 Aug 18. [Online ahead of print]JC
- CONCLUSIONS: KL variation, represented by rs9563124, was associated with aldosterone phenotypes and salt-sensitive blood pressure. Functional annotation supports a regulatory mechanism linking KL variation to endocrine responsiveness. Independent replication and experimental validation are needed to establish causality and clinical relevance.
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- Finerenone benefits in patients with cardio-kidney-metabolic syndrome with or without history of cancer: the FINE-HEART pooled analysis. [Journal Article]Eur Heart J. 2026 Aug 18. [Online ahead of print]EH
- CONCLUSIONS: Comorbid cancer was frequent in CKM participants and independently associated with worse outcomes, but it did not attenuate the treatment benefit of finerenone.
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- Hypertension in Wilms Tumor at Diagnosis: Proposed Treatment Recommendations Starting From a Bi-Institutional Retrospective Observational Study. [Journal Article]Pediatr Blood Cancer. 2026 Aug 18; :e70617. [Online ahead of print]PB
- CONCLUSIONS: We confirmed the high prevalence of AH at WT diagnosis and identified tumor-related factors associated with an increased risk of developing AH. The key elements for the adequate management of these patients include the use of appropriate antihypertensive therapy and proper routine blood pressure screening for all patients with a new WT diagnosis. In the absence of standardized treatment guidelines, we propose recommendations developed through collaboration among pediatric oncologists, cardiologists, and nephrologists.
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- Association of elevated homocysteine levels with renal pathology and function in patients with IgA nephropathy: a single-center retrospective study. [Journal Article]Ann Med. 2026 Dec; 58(1):2720379.AM
- CONCLUSIONS: Elevated Hcy levels are associated with pathological severity and worse kidney function in IgAN patients. However, this association was largely attenuated after adjusting for renal function, and the AUC of 0.756 indicates only modest discriminative ability. Hcy should be used together with other clinical and pathological markers, not as a standalone prognostic tool. Whether lowering Hcy levels can modify IgAN progression remains to be determined in prospective studies.
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- A Systematic Review and Meta-Analysis on 30-Day Readmission Rates After Endovascular Abdominal Aortic Aneurysm Repair and Open Repair. [Systematic Review]Ann Ital Chir. 2026 Aug 13; 97(8):1317-1333.AI
- CONCLUSIONS: EVAR was associated with lower pooled 30-day readmission rates and shorter hospital stays than OAR. However, direct comparative meta-analysis indicated no significant difference in 30-day readmission rates between procedures. At the study level, readmission was linked to patient comorbidity and postoperative complications, whereas no significant association was observed between length of stay and readmission. Given the observational design, substantial heterogeneity, and potential residual confounding, these findings should be interpreted with caution. Long-term outcomes were not assessed.
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- Impact of Thyroid Function Status on Perioperative Characteristics and Early Postoperative Recovery in Cesarean Section. [Journal Article]Ann Ital Chir. 2026 Aug 13; 97(8):1423-1432.AI
- CONCLUSIONS: Thyroid dysfunction was associated with intraoperative hemodynamic instability and delayed early postoperative recovery in cesarean section, with distinct clinical characteristics between hypothyroidism and hyperthyroidism. Perioperative monitoring and management should be enhanced for these patients.
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- Comparison of Labetalol With Versus Without Magnesium Sulfate on Intraoperative Blood Pressure Variability During Cesarean Delivery in Hypertensive Disorders of Pregnancy: A Retrospective Cohort Study. [Journal Article]Ann Ital Chir. 2026 Aug 13; 97(8):1471-1479.AI
- CONCLUSIONS: For HDP patients undergoing cesarean delivery, the perioperative application of a combined regimen of labetalol and magnesium sulfate, compared with labetalol alone, was associated with more stable intraoperative blood pressure, reduced variability under surgical stress, and improved early neonatal outcomes. This combined regimen provides valuable clinical reference for optimizing perioperative blood pressure management during cesarean delivery.
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- Combined Post- and Precapillary Pulmonary Hypertension in Patients With Advanced Heart Failure. [Review]Circ Heart Fail. 2026 Aug 18; :e014787. [Online ahead of print]CH
- Pulmonary hypertension associated with left heart disease, or group 2 pulmonary hypertension, is common in patients with advanced heart failure. In at least a third of these patients, the pulmonary pressures are disproportionately elevated relative to left heart filling pressures and are classified as combined post- and precapillary pulmonary hypertension (CpcPH). CpcPH is thought to result not o…
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- A shortage of nephrologists: workforce decline on both sides of the Atlantic. [Journal Article]J Nephrol. 2026 Aug 18. [Online ahead of print]JN
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