Knee osteoarthritis (OA) is a leading cause of chronic pain and disability. With projections indicating 642 million affected individuals globally by 2050, identifying safe, scalable, and potentially disease-modifying non-pharmacological interventions is an urgent public health priority. This study aims to compare the clinical effectiveness of Tai Chi, Baduanjin, and a health-education programme in preserving joint function and quality of life for patients with knee OA.

Baker's cysts, also known as popliteal cysts, are fluid-filled sacs that are found in the posterior region of the knee, behind the medial head of the gastrocnemius and the semimembranosus. The prevalence has been found to increase with age, with some ultrasonographic studies showing a prevalence as high as 25% of adults with knee pain. We discuss an interesting case of a 14-year- old male with a ruptured cyst found to be secondary to Lyme disease. The patient was treated with clindamycin and his symptoms had resolved. We discuss cases of ruptured baker's cysts in the literature found to be secondary to Lyme disease with their respective treatments and outcomes.

While electroacupuncture (EA) alleviates pain in knee osteoarthritis (KOA), high-quality evidence from large trials is limited, and its potential to influence structural progression is unknown. We investigated whether EA confers structural benefits beyond symptom relief.

Bilateral patellar tendon rupture is an uncommon injury, particularly in young, healthy individuals without established risk factors for tendinopathy. Most reported cases involve systemic disease or medication-related tendon compromise. We present a rare case of simultaneous bilateral patellar tendon rupture in a healthy, athletic male following an indirect mechanism of injury.

Knee osteoarthritis affects 40% of people during their lifetime, significantly impacting societies worldwide. Its molecular pathogenesis remains poorly understood and variable clinical phenotypes suggest it may be more than one disease. We established Synovial fluid To detect Endotypes by Unbiased Proteomics in OA (STEpUP OA) to search for molecular endotypes in knee OA synovial fluid, and to reveal key pathobiological pathways across 1361 individuals with knee OA. Using unsupervised clustering, a single cluster representing a biological continuum is observed, primarily driven by "Epithelial Mesenchymal Transition". Distinct molecular endotypes are not detected. "Angiogenesis", "Complement" and "Coagulation" are enriched for after stratification by clinical phenotype (obesity status, biological sex). Complement and coagulation are associated with the inflammatory marker, C-reactive protein. Associations with patient-reported knee pain are weaker. These findings support knee OA as a biological continuum, identify common and phenotype-enriched targetable pathways, and a rationale for stratification in clinical trial design.

Early mobilisation following total joint arthroplasty is crucial in considering patients for successful same-day discharge (SDD). Recent years have seen an increase in SDD after total joint arthroplasty, with complication rates comparable to those with prolonged hospital stays. Orthostatic intolerance (OI) is a significant barrier to successful SDD after total hip and knee arthroplasties, with up to 52% of patients experiencing it. Patient-related factors include being female, being elderly, having multiple comorbidities, possessing a higher American Society of Anesthesiologists (ASA) status, experiencing pain levels exceeding 5/10, and using gabapentin. Surgery-related risk factors identified were spinal anaesthesia versus general anaesthesia, hip replacement versus knee replacement, and postoperative opioid use. Non-pharmacological and pharmacological approaches can be used to categorise management strategies. However, no treatment has conclusively proven to address OI fully.