- Robotic-arm-assisted versus conventional total knee replacement (RACER-Knee): a pragmatic, multicentre, participant-masked and assessor-masked, superiority, randomised controlled trial. [Journal Article]Lancet. 2026 Aug 20. [Online ahead of print]Lct
- CONCLUSIONS: In this pragmatic trial, rTKR as delivered in routine practice was more costly than cTKR and did not provide a clinically meaningful patient benefit at 12 months after randomisation. The two groups had similar safety (ie, harms) profiles.
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- Effect of a COntralateral corticoSTeroid Injection in total knee arthroplasty (COSTI) on postoperative patient reported outcomes: a randomised trial protocol. [Journal Article]BMJ Open. 2026 Aug 19; 16(8):e119997.BO
- Knee osteoarthritis (OA) is a prevalent and debilitating condition, with nearly 50% of patients experiencing bilateral symptoms. Persistent contralateral knee pain after unilateral total knee arthroplasty (TKA) is a common contributor to suboptimal functional recovery and patient dissatisfaction. An intra-articular corticosteroid injection is a safe and widely used non-operative treatment for OA,…
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- Heterogeneity in decision-making engagement among total knee arthroplasty patients in China: a cross-sectional study. [Journal Article]BMJ Open. 2026 Aug 20; 16(8):e118285.BO
- CONCLUSIONS: Distinct decision-making engagement profiles exist among Chinese patients undergoing TKA. Lower patient-perceived shared decision-making scores, lower awareness of medical decision-making and passive decision-making role preferences were associated with membership in less engaged decision-making profiles. Targeted interventions focusing on decision literacy and communication support may help enhance patient engagement in TKA care.
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- Comparison of the Effects of Phenol Neurolysis and Conventional Radiofrequency Thermocoagulation Applied to the Genicular Nerves on Pain in Patients Who Underwent Knee Arthroplasty: A Prospective, Controlled Study. [Journal Article]Pain Med. 2026 Aug 20. [Online ahead of print]PM
- CONCLUSIONS: Phenol neurolysis and conventional RFT of the genicular nerves are effective treatments for patients with persistent pain after knee arthroplasty. The results demonstrating the short-term efficacy of phenol neurolysis in patients undergoing arthroplasty should be supported by long-term follow-up studies.
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- Ultrasound-Guided Genicular Nerve Block: Novel Clinical Role for Postoperative Knee Replacement Surgery Pain Management. [Review]Curr Pain Headache Rep. 2026 Aug 20; 30(1).CP
- Important aspects of knee replacement surgery to consider are regional anesthesia techniques and postoperative analgesia and ambulation.
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- Modulation of the nociceptive withdrawal reflex in walking is not changed by the presence of tonic pain. [Journal Article]Exp Brain Res. 2026 Aug 20; 244(9).EB
- Tonic pain inhibits the nociceptive withdrawal reflex (NWR). NWR magnitude varies across the gait cycle, but it is unknown whether tonic pain affects this phase-dependent modulation of the NWR during walking. Sixteen healthy participants (mean ± SD age: 29 ± 9 years, 3 males) walked on a treadmill with and without tonic pain applied to the left arm. Lower-limb kinematics and electromyography (EMG…
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- INFRAPATELLAR FAT PAD MRI RADIOMICS AND DELTA-RADIOMICS FOR PREDICTING PAIN PROGRESSION IN KNEE OSTEOARTHTRITIS. [Journal Article]Osteoarthr Imaging. 2026; 6 Suppl 1:100452.OI
- CONCLUSIONS: Quantitative MRI radiomics of the IPFP may provide a robust imaging biomarker for predicting KOA pain progression. Incorporating IPFP radiomics, particularly longitudinal delta-radiomics, may improve risk stratification beyond clinical features and conventional semi-quantitative MRI assessment.
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- LONGITUDINAL SENSITIVITY TO CHANGE AND PROGNOSTIC VALIDITY OF AUTOMATICALLY MEASURED EFFUSION SYNOVITIS VOLUME (ESV). [Journal Article]Osteoarthr Imaging. 2026; 6 Suppl 1:100409.OI
- CONCLUSIONS: The ESV - determined from non-contrast enhanced DESS MRI - was sensitive to longitudinal change (an increase) in knees with OA disease progression. The current results should be confirmed using standard clinical MRI sequences (IW TSE FS) and in other cohorts, ideally in direct comparison with contrast enhanced MRI. Yet, the current analysis is promising in that the ESV yielded strong prognostic validity and differentiated well between knees with different types of progression, as well as between (combined) progressors vs. non-progressors.
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- DCE-MRI-DERIVED TISSUE PERFUSION IS DIFFERENTIALLY ASSOCIATED WITH TIBIAL AND FEMORAL BONE DENSITY IN PEOPLE WITH EARLY KNEE OSTEOARTHRITIS. [Journal Article]Osteoarthr Imaging. 2026; 6 Suppl 1:100408.OI
- CONCLUSIONS: Higher periarticular inflammation may be associated with compromised femoral bone density but higher tibial bone density among individuals with early knee OA and established symptoms, suggesting site-specific relationships. Longitudinal studies are needed to establish temporality and whether accumulated inflammation contributes to progressive bone deterioration.
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- ASSOCIATION OF SYNOVITIS ACTIVITY MEASURED BY SYNOVIAL TISSUE VOLUME (STV) AND DYNAMIC CONTRAST-ENHANCED (DCE)-MRI IN PATIENTS WITH INFLAMMATORY KNEE OSTEOARTHRITIS. [Journal Article]Osteoarthr Imaging. 2026; 6 Suppl 1:100407.OI
- CONCLUSIONS: Although it may be expected that physiologic measures of synovial perfusion (Ktrans) and morphological measures of STV may be measuring somewhat different constructs, the strong correlations between STV and Ktrans measures here demonstrate the potential for the simpler static CE method to be used for quantitative synovitis assessment in clinical trials. STV is more usually measured using high resolution pre- and post-contrast MR images rather than the low-resolution DCE images employed here, which may further improve the association between these measures.
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- LONGITUDINAL CHANGES IN PERI-ARTICULAR BMD USING QUANTITATIVE CT IN KNEE OA PATIENTS: DATA FROM THE IMI-APPROACH STUDY. [Journal Article]Osteoarthr Imaging. 2026; 6 Suppl 1:100404.OI
- CONCLUSIONS: Periarticular BMD change around the knee is common among patients with knee OA. There are bone- and depth-specific changes in periarticular BMD that are influenced by radiographic status. Future studies investigating the association of CT based BMD changes with knee OA-related pain and functional impairments may help determine the clinical significance of these QCT based findings.
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- PROGNOSTIC VALIDITY AND SENSITIVITY TO CHANGE OF AUTOMATICALLY MEASURED HOFFA RADIOMICS IN PROGRESSOR VS. NON-PROGRESSOR KNEES. [Journal Article]Osteoarthr Imaging. 2026; 6 Suppl 1:100446.OI
- CONCLUSIONS: Hoffa MRI radiomic measures appear to be associated with combined and isolated radiographic progression, but not isolated pain progression in knee OA. This supports their role as quantitative prognostic markers of structural disease activity in the absence of CE MRI. Their high responsiveness (sensitivity to change) suggests utility for monitoring disease progression in clinical trials, pending validation of their responsiveness to treatment (predictive validity).
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- MRI-DERIVED POPLITEAL ARTERY WALL BIOMARKERS AND HIP OSTEOARTHRITIS: DATA FROM THE OSTEOARTHRITIS INITIATIVE. [Journal Article]Osteoarthr Imaging. 2026; 6 Suppl 1:100400.OI
- CONCLUSIONS: Automated knee MRI-derived popliteal artery wall biomarkers were associated with prevalent rHOA, sHOA, and frequent hip pain, and mean NWI was associated with 4-year incident frequent hip pain. These findings support opportunistic vascular assessment on knee MRI as a potential imaging marker of vascular-metabolic hip OA and pain phenotypes, although short-term associations with incident structural hip OA were not observed.
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- WALKING MECHANICS DIFFERS BETWEEN ASYMPTOMATIC INDIVIDUALS WITH OR WITHOUT MEDIAL KNEE FULL-THICKNESS CARTILAGE LOSS: DATA FROM THE LAUSANNE KNEE STUDY (LKS). [Journal Article]Osteoarthr Imaging. 2026; 6 Suppl 1:100440.OI
- CONCLUSIONS: This study highlighted a pattern of differences between asymptomatic individuals with medial FTCL and no FTCL. This original result on asymptomatic extends prior literature on symptomatic OA, enhancing our overall understanding of the tripartite interplay among gait alterations, symptoms, and structural lesions.
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- PREDICTING TIME-TO-PAIN PROGRESSION IN KNEE OSTEOARTHRITIS: A CLINICAL AND RADIOMICS FEATURE ANALYSIS. [Journal Article]Osteoarthr Imaging. 2026; 6 Suppl 1:100434.OI
- CONCLUSIONS: Neither baseline clinical variables nor MRI-derived radiomics features could meaningfully predict the year of knee pain progression. These findings highlight the inherent difficulty of temporal pain prediction: pain is a subjective experience influenced by psychological, social, and neurological factors beyond what baseline clinical scores or structural joint features can capture. The severe class imbalance across progression years further compounds this challenge. These results suggest that predicting time-to-pain progression in KOA may require richer data, deep learning-based imaging features, or multimodal integration, and underscore that this remains a fundamentally difficult prediction task.
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