- Knowledge and Determinants of Nonalcoholic Fatty Liver Disease Among Adults in Northern Border Region, Saudi Arabia: A Cross-Sectional Study. [Journal Article]Diseases. 2026 Apr 09; 14(4).D
- CONCLUSIONS: This study demonstrates generally low levels of NAFLD knowledge among adults in the Northern Border Region of Saudi Arabia, with only a minority achieving good knowledge scores. The findings underscore the need for targeted health promotion initiatives, educational interventions, and public campaigns to improve awareness of NAFLD and to support its prevention and management.
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- The future of hepatology: Preventing liver disease together with the public, scientists and artificial intelligence. [Journal Article]JHEP Rep. 2026 Apr 22; :101846. [Online ahead of print]JR
- CONCLUSIONS: These proposals illustrate how participatory approaches may strengthen trust, public engagement and innovation in hepatology, supporting societal involvement in research and prevention. Intended as catalysts for dialogue, we invite the hepatology community to shape these and related participatory initiatives, thereby strengthening communication and public education while positioning hepatology at the forefront of innovative and trust-building medicine.
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- Validation of the Southampton Difficulty Scoring System in Robotic Liver Surgery and Development of the International RoboLiver Difficulty Scoring System. [Journal Article]J Am Coll Surg. 2026 May 01. [Online ahead of print]JA
- CONCLUSIONS: Difficulty factors in RLS partially overlap with LLS but are not directly transferable. The International RoboLiver DSS provides a calibrated, robot-specific tool for preoperative complexity stratification and operative planning in RLS. External validation is required.
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- An Explainable Artificial Intelligence Tool (FibroX) for Detecting Advanced Liver Fibrosis in Type 2 Diabetes: Protocol for a Pilot Crossover Trial. [Journal Article]JMIR Res Protoc. 2026 Apr 13. [Online ahead of print]JR
- CONCLUSIONS: This pilot study will provide preliminary evidence on the feasibility, usability, and diagnostic performance of an explainable artificial intelligence tool for fibrosis risk stratification in diabetes care and will inform the design of a future larger trial.
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- GLP-1RA plus SGLT2i combination therapy and liver fibrosis progression in MASLD with type 2 diabetes. [Journal Article]Hepatol Commun. 2026 May 01; 10(5).HC
- CONCLUSIONS: GLP-1RA plus SGLT2i therapy was associated with reduced fibrosis progression compared with GLP-1RA monotherapy in MASLD and T2DM.
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- [Update on Diagnosis-Related Groups (DRG) coding 2026 for general and visceral surgery : From the Department for Health Economics Section of the German Society for General and Visceral Surgery (DGAV)]. [Review]
- For the 2026 proposal procedure, numerous modifications to the ICD-10-GM and OPS classification were initiated and implemented through the Health Economics Section of the German Society for General and Visceral Surgery at the Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte). The aim is to achieve a more precise and performance-adequate represen…
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- Relationship Between IL6/IL10 Serum Concentrations and Organ Function in Critically Ill Patients Based on Sepsis: A Prospective Study. [Journal Article]Immun Inflamm Dis. 2026 Apr; 14(4):e70414.II
- CONCLUSIONS: Our study showed that in critically ill patients, particularly those with sepsis, IL6/IL10 is significantly associated with outcomes such as organ dysfunction (including coagulation, renal, cardiac, and pulmonary function). These findings are hypothesis-generating, suggesting that IL6/IL10 may serve as a valuable indicator associated with inflammation and severity changes in critical illness.
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- Uncommon Combination of Low Alanine Aminotransferase and High Fatty Liver Index Associated With High Charlson Comorbidity Index: Insights From the K7Ps-Study-7. [Journal Article]J Clin Med Res. 2026 Mar; 18(3):168-176.JC
- CONCLUSIONS: The uncommon combination of low ALT and fatty liver may be associated with high CCI, and older and more often women with the aspects of frailty, which was disclosed by the consideration of fatty liver, suggesting a phenomenon related to obesity paradox.
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- Performance evaluation of mainstream large language models in autoimmune hepatitis patient education: a comparative study of readability, quality, and reliability. [Journal Article]Front Public Health. 2026; 14:1805848.FP
- CONCLUSIONS: Substantial variability exists among LLMs in generating AIH patient education materials. Model selection critically influences information quality and educational suitability, whereas content theme primarily affects linguistic complexity. Although most models produced moderate-to-good quality information, relatively high readability levels suggest that further simplification may be needed for general patient populations. A multidimensional evaluation framework integrating readability, quality, educational suitability, and clinical intent alignment is essential for the responsible use of LLMs in AIH patient education.
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- Comprehensive Pharmacovigilance Assessment of Pegvisomant-Associated Adverse Events Using the FAERS and WHO VigiAccess Databases. [Journal Article]Endocr Pract. 2026 Mar 31. [Online ahead of print]EP
- CONCLUSIONS: This analysis identified reproducible reporting patterns for pegvisomant across two pharmacovigilance databases. Endocrine and laboratory-related terms were mainly interpreted as monitoring-related findings, whereas clinically relevant suspected adverse reaction signals were more evident for hepatobiliary events, injection-site reactions, and product administration-related problems. These findings support continued biochemical monitoring, liver surveillance, and careful long-term follow-up during pegvisomant therapy.
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- Small Round Cell Tumors of Soft Tissue and Skeleton in Children and Youth: A Narrative and TruSight-Based Illustrative Review of Diagnostic Cases. [Journal Article]Adv Anat Pathol. 2026 Apr 03. [Online ahead of print]AA
- Small round cell tumors (SRCT) affecting soft tissue and bone are a distinct category of malignancies. These lesions frequently exhibit similar clinical and radiologic features, may harbor overlapping histologic and immunophenotypic features, and generally have distinct prognostic outcomes. Therefore, in some instances, the diagnosis and accurate subclassification require molecular confirmation. …
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- Comparative diagnostic performance of ultrasound-guided attenuation parameter versus B-mode scoring for hepatic steatosis assessment: an ordinal-scale statistical approach. [Journal Article]
- CONCLUSIONS: Ordinal-scale-specific methods demonstrate that UGAP provides superior diagnostic performance over conventional B-mode scoring, better reflecting graduated disease severity and the clinical consequences of misclassification. (University Hospital Medical Information Network000041196).
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- Global, regional, and national burden of meningitis, its risk factors, and aetiologies, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. [Systematic Review]Lancet Neurol. 2026 May; 25(5):451-468.LN
- CONCLUSIONS: Although mortality and incidence have declined significantly since 1990, progress is insufficient to meet WHO 2030 targets. Despite marked progress in reducing bacterial meningitis via global vaccination campaigns, a substantial meningitis burden persists, attributable both to common pathogens such as S pneumoniae and N meningitidis and to emerging non-bacterial pathogens such as Candida spp and drug-resistant fungi. Achieving WHO goals will require sustained investment in surveillance, vaccination, maternal screening, and health-system strengthening, especially in high-burden settings.
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- Liver and peritoneal metastases of unknown primary site: French Intergroup Clinical Practice guidelines for diagnosis, treatment, and follow-up (TNCD, SNFGE, FFCD, UNICANCER, GERCOR, SFCD, SFED, SFP, SFR, ACHBT, SFRO, SNFCP, AFEF, RENAPE, NET-CAPI). [Review]Eur J Cancer. 2026 Mar 25; 239:116696. [Online ahead of print]EJ
- CONCLUSIONS: These guidelines are intended to provide a state-of -the art management for daily clinical practice. Each individual CUP case should be discussed by a dedicated MTB.
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- From Guidelines to Practice: Case-Based Teaching Module to Improve MASLD Screening in Diabetes Care for Internal Medicine Residents. [Journal Article]MedEdPORTAL. 2026; 22:11586.M
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent, yet underrecognized condition with serious, but preventable, complications. The American Association for the Study of Liver Diseases, American Association of Clinical Endocrinology (2022), and American Diabetes Association (2025) recommend MASLD screening for patients with type 2 diabetes, including using the Fibrosi…
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